DK0456107T3 - Fremgangsmåde til enzymatisk reduktion af oxo-forbindelser, især acetophenon, og dertil egnet enzym - Google Patents

Fremgangsmåde til enzymatisk reduktion af oxo-forbindelser, især acetophenon, og dertil egnet enzym

Info

Publication number
DK0456107T3
DK0456107T3 DK91107067.0T DK91107067T DK0456107T3 DK 0456107 T3 DK0456107 T3 DK 0456107T3 DK 91107067 T DK91107067 T DK 91107067T DK 0456107 T3 DK0456107 T3 DK 0456107T3
Authority
DK
Denmark
Prior art keywords
suitable enzymes
enzymatic reduction
oxo compounds
acetophenone
especially acetophenone
Prior art date
Application number
DK91107067.0T
Other languages
Danish (da)
English (en)
Inventor
Werner Hummel
Original Assignee
Forschungszentrum Juelich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh filed Critical Forschungszentrum Juelich Gmbh
Application granted granted Critical
Publication of DK0456107T3 publication Critical patent/DK0456107T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/853—Lactobacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK91107067.0T 1990-05-07 1991-05-02 Fremgangsmåde til enzymatisk reduktion af oxo-forbindelser, især acetophenon, og dertil egnet enzym DK0456107T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4014573A DE4014573C1 (enExample) 1990-05-07 1990-05-07

Publications (1)

Publication Number Publication Date
DK0456107T3 true DK0456107T3 (da) 1996-03-25

Family

ID=6405860

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91107067.0T DK0456107T3 (da) 1990-05-07 1991-05-02 Fremgangsmåde til enzymatisk reduktion af oxo-forbindelser, især acetophenon, og dertil egnet enzym

Country Status (6)

Country Link
US (1) US5200335A (enExample)
EP (1) EP0456107B1 (enExample)
JP (1) JP2767164B2 (enExample)
CA (1) CA2041837C (enExample)
DE (2) DE4014573C1 (enExample)
DK (1) DK0456107T3 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3574682B2 (ja) * 1993-09-24 2004-10-06 ダイセル化学工業株式会社 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法
DE19610984A1 (de) * 1996-03-21 1997-09-25 Boehringer Mannheim Gmbh Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen
EP1067195B1 (de) * 1999-07-09 2006-09-20 Forschungszentrum Jülich Gmbh Verfahren zur Reduktion von Ketogruppen enthaltende Verbindungen
DE19937825B4 (de) * 1999-07-09 2005-08-11 Forschungszentrum Jülich GmbH Verfahren zur Reduktion von Hydroxyketo-Carbonsäuren und deren Estern
JP2003504070A (ja) * 1999-07-09 2003-02-04 フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツング ケトカルボン酸及びそのエステルの還元のための方法
DE10002975A1 (de) * 2000-01-24 2001-07-26 Degussa Verwendung von molekulargewichtsvergrößerten Katalysatoren in einem Verfahren zur asymmetrischen kontinuierlichen Hydrierung, neue molekulargewichtsvergrößerte Liganden und Katalysatoren
DE10119274A1 (de) 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
FR2826650A1 (fr) * 2001-07-02 2003-01-03 Rhodia Chimie Sa Procede de reduction enantioselectif d'une cetone aromatique prochirale comprenant au moins un groupe trifluoromethyle sur le cycle aromatique
DE102004007029A1 (de) * 2004-02-12 2005-09-08 Consortium für elektrochemische Industrie GmbH Verfahren zur enantioselektiven Reduktion von Ketoverbindungen durch Enzyme
AT502395B1 (de) 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
AT502185B1 (de) * 2005-09-23 2007-02-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
JP5358428B2 (ja) * 2006-04-21 2013-12-04 ビーエーエスエフ ソシエタス・ヨーロピア アルコールデヒドロゲナーゼを用いた光学活性第二級アルコールのラセミ化方法
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
AT504542B1 (de) 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
CN101627116B (zh) 2007-02-08 2013-07-10 科德克希思公司 酮还原酶及其用途
JP2010536385A (ja) * 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
KR101586503B1 (ko) 2007-09-13 2016-01-18 코덱시스, 인코포레이티드 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드
TWI601825B (zh) * 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
CN101889081B (zh) * 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
HUE027683T2 (en) 2007-10-01 2016-10-28 Codexis Inc Ketoreductase polypeptides for the production of azetidinone
WO2010025238A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SI2329014T1 (sl) 2008-08-29 2015-01-30 Codexis, Inc. Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
DE102008054918A1 (de) 2008-12-18 2010-07-01 Evonik Degussa Gmbh Verfahren zur enzymatischen Umsetzung von Alkanen
EP2226386A1 (de) 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
WO2011022548A2 (en) 2009-08-19 2011-02-24 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
JP6023045B2 (ja) 2010-05-27 2016-11-09 ファルマツェル、ゲーエムベーハー 新規７α−ヒドロキシステロイドデヒドロゲナーゼノックアウト突然変異体およびその使用
DE102013104418B4 (de) 2013-04-30 2018-09-27 Cambrex Iep Gmbh Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60128289A (ja) 1983-12-12 1985-07-09 Orient Watch Co Ltd 複合めつき方法
JPS61285993A (ja) 1985-06-14 1986-12-16 Idemitsu Kosan Co Ltd フェナシルアルコ−ル類の製造方法

Also Published As

Publication number Publication date
EP0456107A2 (de) 1991-11-13
CA2041837C (en) 2002-06-18
EP0456107A3 (en) 1992-03-25
DE59107265D1 (de) 1996-02-29
US5200335A (en) 1993-04-06
JP2767164B2 (ja) 1998-06-18
EP0456107B1 (de) 1996-01-17
JPH04330278A (ja) 1992-11-18
CA2041837A1 (en) 1991-11-08
DE4014573C1 (enExample) 1991-10-10

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