DK0443532T3 - Syntese af LH-RH analoger ved temporær minimalbeskyttelse - Google Patents
Syntese af LH-RH analoger ved temporær minimalbeskyttelseInfo
- Publication number
- DK0443532T3 DK0443532T3 DK91102370.3T DK91102370T DK0443532T3 DK 0443532 T3 DK0443532 T3 DK 0443532T3 DK 91102370 T DK91102370 T DK 91102370T DK 0443532 T3 DK0443532 T3 DK 0443532T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- analogs
- minimal protection
- temporary
- temporary minimal
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000012351 deprotecting agent Substances 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Bipolar Integrated Circuits (AREA)
- Liquid Developers In Electrophotography (AREA)
- Amplifiers (AREA)
- Escalators And Moving Walkways (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Electrophonic Musical Instruments (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Variable-Direction Aerials And Aerial Arrays (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Golf Clubs (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
- Semiconductor Integrated Circuits (AREA)
- Fuses (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48242890A | 1990-02-20 | 1990-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0443532T3 true DK0443532T3 (da) | 1994-07-25 |
Family
ID=23916033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91102370.3T DK0443532T3 (da) | 1990-02-20 | 1991-02-19 | Syntese af LH-RH analoger ved temporær minimalbeskyttelse |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0443532B1 (de) |
| JP (1) | JP2927978B2 (de) |
| KR (1) | KR0152276B1 (de) |
| AT (1) | ATE107931T1 (de) |
| AU (1) | AU639751B2 (de) |
| CA (1) | CA2036657C (de) |
| DE (1) | DE69102659T2 (de) |
| DK (1) | DK0443532T3 (de) |
| ES (1) | ES2057624T3 (de) |
| FI (1) | FI102538B (de) |
| HK (1) | HK43097A (de) |
| HU (1) | HU208158B (de) |
| IE (1) | IE71945B1 (de) |
| NO (1) | NO309428B1 (de) |
| NZ (1) | NZ237159A (de) |
| PH (1) | PH31062A (de) |
| PT (1) | PT96807B (de) |
| ZA (1) | ZA911233B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104231055A (zh) | 2013-06-18 | 2014-12-24 | 深圳翰宇药业股份有限公司 | 加尼瑞克前体以及由其制备醋酸加尼瑞克的方法 |
| KR101971418B1 (ko) * | 2017-06-30 | 2019-04-24 | 애니젠 주식회사 | 고세렐린의 제조 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4301066A (en) * | 1980-05-08 | 1981-11-17 | American Home Products Corp. | Preparation of (D-Trp 6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 |
| US4632979A (en) * | 1984-06-18 | 1986-12-30 | Tulane Educational Fund | Therapeutic LHRH analogs |
| US4677193A (en) * | 1985-02-22 | 1987-06-30 | The Salk Institute For Biological Studies | Peptides containing an aliphatic-aromatic ketone side chain |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
-
1991
- 1991-02-19 ES ES91102370T patent/ES2057624T3/es not_active Expired - Lifetime
- 1991-02-19 CA CA002036657A patent/CA2036657C/en not_active Expired - Lifetime
- 1991-02-19 PH PH42022A patent/PH31062A/en unknown
- 1991-02-19 AT AT91102370T patent/ATE107931T1/de not_active IP Right Cessation
- 1991-02-19 HU HU91543A patent/HU208158B/hu unknown
- 1991-02-19 DE DE69102659T patent/DE69102659T2/de not_active Expired - Lifetime
- 1991-02-19 IE IE55691A patent/IE71945B1/en not_active IP Right Cessation
- 1991-02-19 ZA ZA911233A patent/ZA911233B/xx unknown
- 1991-02-19 DK DK91102370.3T patent/DK0443532T3/da active
- 1991-02-19 AU AU71176/91A patent/AU639751B2/en not_active Expired
- 1991-02-19 KR KR1019910002623A patent/KR0152276B1/ko not_active Expired - Lifetime
- 1991-02-19 FI FI910788A patent/FI102538B/fi active
- 1991-02-19 PT PT96807A patent/PT96807B/pt not_active IP Right Cessation
- 1991-02-19 NZ NZ237159A patent/NZ237159A/en unknown
- 1991-02-19 EP EP91102370A patent/EP0443532B1/de not_active Expired - Lifetime
- 1991-02-19 NO NO910664A patent/NO309428B1/no not_active IP Right Cessation
- 1991-02-20 JP JP3026462A patent/JP2927978B2/ja not_active Expired - Lifetime
-
1997
- 1997-04-03 HK HK43097A patent/HK43097A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT96807A (pt) | 1991-10-31 |
| EP0443532B1 (de) | 1994-06-29 |
| PT96807B (pt) | 1998-07-31 |
| NO910664L (no) | 1991-08-21 |
| FI102538B1 (fi) | 1998-12-31 |
| HU208158B (en) | 1993-08-30 |
| NO910664D0 (no) | 1991-02-19 |
| FI910788L (fi) | 1991-08-21 |
| HK43097A (en) | 1997-04-11 |
| KR0152276B1 (ko) | 1998-10-01 |
| EP0443532A2 (de) | 1991-08-28 |
| HUT57234A (en) | 1991-11-28 |
| FI910788A0 (fi) | 1991-02-19 |
| NZ237159A (en) | 1992-11-25 |
| EP0443532A3 (en) | 1992-02-26 |
| DE69102659D1 (de) | 1994-08-04 |
| AU639751B2 (en) | 1993-08-05 |
| ES2057624T3 (es) | 1994-10-16 |
| ATE107931T1 (de) | 1994-07-15 |
| CA2036657A1 (en) | 1991-08-21 |
| IE71945B1 (en) | 1997-03-12 |
| KR910021411A (ko) | 1991-12-20 |
| PH31062A (en) | 1998-02-05 |
| FI102538B (fi) | 1998-12-31 |
| JP2927978B2 (ja) | 1999-07-28 |
| DE69102659T2 (de) | 1995-02-23 |
| NO309428B1 (no) | 2001-01-29 |
| IE910556A1 (en) | 1991-08-28 |
| JPH04211096A (ja) | 1992-08-03 |
| CA2036657C (en) | 2003-02-11 |
| AU7117691A (en) | 1991-08-22 |
| HU910543D0 (en) | 1991-09-30 |
| ZA911233B (en) | 1992-10-28 |
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