DK0406992T3 - New non-ionic carboxamide contrast agents - Google Patents

New non-ionic carboxamide contrast agents

Info

Publication number
DK0406992T3
DK0406992T3 DK90250167.5T DK90250167T DK0406992T3 DK 0406992 T3 DK0406992 T3 DK 0406992T3 DK 90250167 T DK90250167 T DK 90250167T DK 0406992 T3 DK0406992 T3 DK 0406992T3
Authority
DK
Denmark
Prior art keywords
carboxamide
ionic
contrast agents
new non
compounds
Prior art date
Application number
DK90250167.5T
Other languages
Danish (da)
Inventor
Milos Dr Sovak
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0406992T3 publication Critical patent/DK0406992T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Triiodo-5-aminoisophthalamides in which the amino and one of the amide nitrogen groups are substituted are indicated. The compounds have at least two hydroxyl groups and low viscosity and osmolality. Processes for the preparation of the compounds are indicated.
DK90250167.5T 1989-07-05 1990-06-29 New non-ionic carboxamide contrast agents DK0406992T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37571489A 1989-07-05 1989-07-05
US43152789A 1989-11-03 1989-11-03

Publications (1)

Publication Number Publication Date
DK0406992T3 true DK0406992T3 (en) 1995-07-24

Family

ID=27007168

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90250167.5T DK0406992T3 (en) 1989-07-05 1990-06-29 New non-ionic carboxamide contrast agents

Country Status (16)

Country Link
EP (1) EP0406992B1 (en)
JP (1) JP3249112B2 (en)
AT (1) ATE119783T1 (en)
AU (1) AU643447B2 (en)
CA (1) CA2020489C (en)
CS (1) CS277109B6 (en)
DE (1) DE59008695D1 (en)
DK (1) DK0406992T3 (en)
ES (1) ES2069677T3 (en)
GR (1) GR3015580T3 (en)
HU (1) HU219585B (en)
IE (1) IE65719B1 (en)
IL (1) IL94718A (en)
NO (1) NO179247C (en)
PT (1) PT94595B (en)
RU (1) RU2060246C1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4109169A1 (en) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz WATER-SOLUBLE NON-IONIC X-RAY CONTRASTING AGENTS AND AGENTS AND METHOD FOR THE PRODUCTION THEREOF
DE4341472A1 (en) * 1993-12-02 1995-06-08 Schering Ag A method for increasing the stability of liposome suspensions containing hydrophilic drugs
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
DE19731591C2 (en) * 1997-07-17 1999-09-16 Schering Ag Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology
ITMI20010773A1 (en) * 2001-04-11 2002-10-11 Chemi Spa PROCESS FOR THE PRODUCTION OF HIGH PURITY IOEXOLO
KR20100033405A (en) * 2007-07-12 2010-03-29 지이 헬스케어 에이에스 Contrast agents
EP2240432B1 (en) 2008-01-14 2012-07-04 Mallinckrodt LLC Process for the preparation of iosimenol
EP2093206A1 (en) * 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2230227A1 (en) * 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
BR112012001103B1 (en) 2009-07-07 2021-05-11 Bracco Imaging Spa process for preparing an iodinating agent
AU2013323982B2 (en) 2012-09-27 2017-11-23 Ge Healthcare As Preparation of Ioforminol, an X-ray contrast agent
JP7090645B2 (en) * 2017-05-01 2022-06-24 大塚製薬株式会社 Manufacturing method of iocimenol

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
GB1538076A (en) * 1974-11-15 1979-01-10 Addressograph Multigraph Apparatus for electrostatic reprography
CH608189A5 (en) * 1974-12-13 1978-12-29 Savac Ag
FI760068A (en) * 1975-02-03 1976-08-04 Schering Ag
FR2435253A1 (en) * 1978-07-04 1980-04-04 Nyegaard & Co As PROCESS FOR THE PREPARATION OF A BUFFERED SOLUTION OF A CONTRAST SUBSTANCE FOR X-RAYS, AND PRODUCTS OBTAINED BY THIS PROCESS
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
NL7905021A (en) * 1979-06-27 1980-12-30 Pielkenrood Vinitex Bv DEVICE FOR SEPARATING SUSPENDED COMPONENTS FROM A LIQUID.
DE3001292A1 (en) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin NON-ionic 5-C SUBSTITUTED 2,4,6-TRIJOD ISOPHTHALIC ACID DERIVATIVES
DE3150916A1 (en) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-HYDROXYAETHYLATED 2,4,6-TRIJODAMINOISIOPHTHALIC ACID-BISTRIHYDROXYBUTYLAMIDES, THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRASTING AGENTS "
DE3731542A1 (en) * 1987-09-17 1989-03-30 Schering Ag NEW DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIIOD-ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THESE CONTAINING X-RAY AGENTS
DE3739098A1 (en) * 1987-11-16 1989-05-24 Schering Ag NEW SUBSTITUTED DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIYOD ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING X-RAY CONTRASTING AGENTS
EP0425482B1 (en) * 1988-07-20 1993-08-18 Novo Nordisk A/S Human insulin analogs and preparations containing them

Also Published As

Publication number Publication date
AU5869490A (en) 1991-01-10
HUT57708A (en) 1991-12-30
IE902340A1 (en) 1991-01-16
JP3249112B2 (en) 2002-01-21
IL94718A (en) 1994-10-21
NO179247C (en) 1996-09-04
PT94595A (en) 1991-03-20
CS335390A3 (en) 1992-01-15
AU643447B2 (en) 1993-11-18
EP0406992A3 (en) 1991-09-18
NO902986D0 (en) 1990-07-04
IL94718A0 (en) 1991-04-15
EP0406992B1 (en) 1995-03-15
PT94595B (en) 1997-02-28
EP0406992A2 (en) 1991-01-09
HU219585B (en) 2001-05-28
IE65719B1 (en) 1995-11-15
CA2020489C (en) 2005-01-11
JPH03115232A (en) 1991-05-16
NO902986L (en) 1991-01-07
DE59008695D1 (en) 1995-04-20
GR3015580T3 (en) 1995-06-30
NO179247B (en) 1996-05-28
CA2020489A1 (en) 1991-01-06
RU2060246C1 (en) 1996-05-20
ES2069677T3 (en) 1995-05-16
CS277109B6 (en) 1992-11-18
ATE119783T1 (en) 1995-04-15
HU904104D0 (en) 1990-12-28

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