CA2020489A1 - Carboxamide non-ionic contrast media - Google Patents

Carboxamide non-ionic contrast media

Info

Publication number
CA2020489A1
CA2020489A1 CA002020489A CA2020489A CA2020489A1 CA 2020489 A1 CA2020489 A1 CA 2020489A1 CA 002020489 A CA002020489 A CA 002020489A CA 2020489 A CA2020489 A CA 2020489A CA 2020489 A1 CA2020489 A1 CA 2020489A1
Authority
CA
Canada
Prior art keywords
contrast media
ionic contrast
carboxamide
carboxamide non
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002020489A
Other languages
French (fr)
Other versions
CA2020489C (en
Inventor
Milos Sovak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biophysica Foundation
Original Assignee
Milos Sovak
Schering Aktiengesellschaft
Biophysica, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Milos Sovak, Schering Aktiengesellschaft, Biophysica, Inc. filed Critical Milos Sovak
Publication of CA2020489A1 publication Critical patent/CA2020489A1/en
Application granted granted Critical
Publication of CA2020489C publication Critical patent/CA2020489C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection

Abstract

Novel triiodo 5-aminoisophthaldiamides are provided, where the amino and one of the amide nitrogens are substituted. The compounds have at least two hydroxyl groups and are found to provide low viscosity and osmolality. Procedures for preparing the compounds are provided.
CA002020489A 1989-07-05 1990-07-05 Carboxamide non-ionic contrast media Expired - Lifetime CA2020489C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37571489A 1989-07-05 1989-07-05
US375,714 1989-07-05
US43152789A 1989-11-03 1989-11-03
US431,527 1989-11-03

Publications (2)

Publication Number Publication Date
CA2020489A1 true CA2020489A1 (en) 1991-01-06
CA2020489C CA2020489C (en) 2005-01-11

Family

ID=27007168

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002020489A Expired - Lifetime CA2020489C (en) 1989-07-05 1990-07-05 Carboxamide non-ionic contrast media

Country Status (16)

Country Link
EP (1) EP0406992B1 (en)
JP (1) JP3249112B2 (en)
AT (1) ATE119783T1 (en)
AU (1) AU643447B2 (en)
CA (1) CA2020489C (en)
CS (1) CS277109B6 (en)
DE (1) DE59008695D1 (en)
DK (1) DK0406992T3 (en)
ES (1) ES2069677T3 (en)
GR (1) GR3015580T3 (en)
HU (1) HU219585B (en)
IE (1) IE65719B1 (en)
IL (1) IL94718A (en)
NO (1) NO179247C (en)
PT (1) PT94595B (en)
RU (1) RU2060246C1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445725B2 (en) 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
US9157156B2 (en) 2009-07-07 2015-10-13 Bracco Imaging S.P.A. Process for the preparation of a iodinating agent
US9193659B2 (en) 2008-02-20 2015-11-24 Bracco Imaging S.P.A. Process for the iodination of aromatic compounds

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4109169A1 (en) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz WATER-SOLUBLE NON-IONIC X-RAY CONTRASTING AGENTS AND AGENTS AND METHOD FOR THE PRODUCTION THEREOF
DE4341472A1 (en) * 1993-12-02 1995-06-08 Schering Ag A method for increasing the stability of liposome suspensions containing hydrophilic drugs
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
DE19731591C2 (en) * 1997-07-17 1999-09-16 Schering Ag Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology
ITMI20010773A1 (en) * 2001-04-11 2002-10-11 Chemi Spa PROCESS FOR THE PRODUCTION OF HIGH PURITY IOEXOLO
JP5340281B2 (en) * 2007-07-12 2013-11-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ Contrast agent
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
BR112015004580A2 (en) 2012-09-27 2017-07-04 Ge Healthcare As process for the preparation of a compound, compound, and, composition
KR20190140036A (en) * 2017-05-01 2019-12-18 오츠카 세이야쿠 가부시키가이샤 Method of Making Iosimol

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
GB1538076A (en) * 1974-11-15 1979-01-10 Addressograph Multigraph Apparatus for electrostatic reprography
CH608189A5 (en) * 1974-12-13 1978-12-29 Savac Ag
FI760068A (en) * 1975-02-03 1976-08-04 Schering Ag
ZA793313B (en) * 1978-07-04 1980-08-27 Nyegaard & Co As A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
NL7905021A (en) * 1979-06-27 1980-12-30 Pielkenrood Vinitex Bv DEVICE FOR SEPARATING SUSPENDED COMPONENTS FROM A LIQUID.
DE3001292A1 (en) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin NON-ionic 5-C SUBSTITUTED 2,4,6-TRIJOD ISOPHTHALIC ACID DERIVATIVES
DE3150916A1 (en) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-HYDROXYAETHYLATED 2,4,6-TRIJODAMINOISIOPHTHALIC ACID-BISTRIHYDROXYBUTYLAMIDES, THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRASTING AGENTS "
DE3731542A1 (en) * 1987-09-17 1989-03-30 Schering Ag NEW DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIIOD-ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THESE CONTAINING X-RAY AGENTS
DE3739098A1 (en) * 1987-11-16 1989-05-24 Schering Ag NEW SUBSTITUTED DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIYOD ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING X-RAY CONTRASTING AGENTS
WO1990001038A1 (en) * 1988-07-20 1990-02-08 Nordisk Gentofte A/S Human insulin analogs and preparations containing them

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445725B2 (en) 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
US8680334B2 (en) 2008-01-14 2014-03-25 Mallinckrodt Llc Process for the preparation of iosimenol
US9193659B2 (en) 2008-02-20 2015-11-24 Bracco Imaging S.P.A. Process for the iodination of aromatic compounds
US9157156B2 (en) 2009-07-07 2015-10-13 Bracco Imaging S.P.A. Process for the preparation of a iodinating agent

Also Published As

Publication number Publication date
DK0406992T3 (en) 1995-07-24
ES2069677T3 (en) 1995-05-16
PT94595A (en) 1991-03-20
NO179247C (en) 1996-09-04
GR3015580T3 (en) 1995-06-30
IE65719B1 (en) 1995-11-15
EP0406992A2 (en) 1991-01-09
EP0406992B1 (en) 1995-03-15
AU5869490A (en) 1991-01-10
HUT57708A (en) 1991-12-30
IE902340A1 (en) 1991-01-16
IL94718A0 (en) 1991-04-15
HU904104D0 (en) 1990-12-28
RU2060246C1 (en) 1996-05-20
CA2020489C (en) 2005-01-11
PT94595B (en) 1997-02-28
IL94718A (en) 1994-10-21
CS335390A3 (en) 1992-01-15
JPH03115232A (en) 1991-05-16
NO902986L (en) 1991-01-07
AU643447B2 (en) 1993-11-18
JP3249112B2 (en) 2002-01-21
NO179247B (en) 1996-05-28
EP0406992A3 (en) 1991-09-18
CS277109B6 (en) 1992-11-18
HU219585B (en) 2001-05-28
DE59008695D1 (en) 1995-04-20
ATE119783T1 (en) 1995-04-15
NO902986D0 (en) 1990-07-04

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Legal Events

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EEER Examination request
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