DK0387701T3 - Anvendelse af intercellulære adhæsionsmolekyler samt deres bindende ligander ved behandling af astma - Google Patents

Anvendelse af intercellulære adhæsionsmolekyler samt deres bindende ligander ved behandling af astma

Info

Publication number
DK0387701T3
DK0387701T3 DK90104423.0T DK90104423T DK0387701T3 DK 0387701 T3 DK0387701 T3 DK 0387701T3 DK 90104423 T DK90104423 T DK 90104423T DK 0387701 T3 DK0387701 T3 DK 0387701T3
Authority
DK
Denmark
Prior art keywords
asthma
treatment
well
adhesion molecules
intercellular adhesion
Prior art date
Application number
DK90104423.0T
Other languages
Danish (da)
English (en)
Inventor
Robert Rothlein
Craig D Wegner
Robert H Gundel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0387701T3 publication Critical patent/DK0387701T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK90104423.0T 1989-03-09 1990-03-08 Anvendelse af intercellulære adhæsionsmolekyler samt deres bindende ligander ved behandling af astma DK0387701T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32101889A 1989-03-09 1989-03-09
US32123789A 1989-03-09 1989-03-09
US32123989A 1989-03-09 1989-03-09
US32448189A 1989-03-16 1989-03-16
US40140989A 1989-09-01 1989-09-01

Publications (1)

Publication Number Publication Date
DK0387701T3 true DK0387701T3 (da) 1992-12-07

Family

ID=27541038

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90104423.0T DK0387701T3 (da) 1989-03-09 1990-03-08 Anvendelse af intercellulære adhæsionsmolekyler samt deres bindende ligander ved behandling af astma

Country Status (13)

Country Link
EP (1) EP0387701B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3119483B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR0177519B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE79270T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU638450B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2047721C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69000248T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0387701T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2035668T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006073T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU216313B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ232868A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1990010453A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ATE186552T1 (de) 1988-09-01 1999-11-15 Bayer Ag Menschliches rhinovirusrezeptorprotein, das die virusinfektionsanfälligkeit hemmt
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
EP0987329A3 (en) * 1990-07-20 2004-03-03 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
WO1992006119A1 (en) * 1990-10-03 1992-04-16 Boehringer Ingelheim Pharmaceuticals, Inc. Method for treating inflammation using anti-idiotypic antibodies
CA2056143A1 (en) * 1990-11-28 1992-05-29 Michael S. Diamond The mac-1 binding site of icam-1
ES2094837T3 (es) * 1991-04-03 1997-02-01 Boehringer Ingelheim Pharma Metodo para inhibir la toxicidad pulmonar por oxigeno.
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
ES2123570T3 (es) * 1991-07-31 1999-01-16 Boehringer Ingelheim Pharma Uso de la molecula de adhesion de leucocitos y endotelios 1 y anticuerpos contra ella en el tratamiento del asma.
HUT69725A (en) * 1991-10-01 1995-09-28 Gen Hospital Corp Process for producing compositions for preventing allograft rejection
US5871734A (en) * 1992-01-13 1999-02-16 Biogen, Inc. Treatment for asthma with VLA-4 blocking agents
US5708141A (en) * 1992-05-11 1998-01-13 Corvas International, Inc. Neutrophil inhibitors
HUT75827A (en) * 1992-06-22 1997-05-28 Bayer Ag Multimeric forms of human rhinovirus receptor protein
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
CA2454358A1 (en) 2001-07-19 2003-07-31 Perlan Therapeutics, Inc. Multimeric proteins and methods of making and using same
GB0525214D0 (en) 2005-12-12 2006-01-18 Bioinvent Int Ab Biological materials and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2080044T3 (es) * 1987-05-04 1996-02-01 Dana Farber Cancer Inst Inc Moleculas de adhesion intercelular y sus ligandos de fijacion.
ES2064327T3 (es) * 1987-11-02 1995-02-01 Baylor College Medicine Uso de icam-1 o de sus derivados funcionales para el tratamiento de una inflamacion no especifica.
CA1341055C (en) * 1987-12-08 2000-07-18 Alan Mcclelland Transfectant cell lines which express the major human rhinovirus receptor

Also Published As

Publication number Publication date
CA2047721A1 (en) 1990-09-10
AU638450B2 (en) 1993-07-01
WO1990010453A1 (en) 1990-09-20
ES2035668T3 (es) 1993-04-16
JPH04504127A (ja) 1992-07-23
EP0387701B1 (en) 1992-08-12
NZ232868A (en) 1995-05-26
HU216313B (hu) 1999-06-28
JP3119483B2 (ja) 2000-12-18
EP0387701A1 (en) 1990-09-19
DE69000248T2 (de) 1993-01-07
KR0177519B1 (ko) 1999-03-20
CA2047721C (en) 2004-01-06
ATE79270T1 (de) 1992-08-15
GR3006073T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-21
HUT65843A (en) 1994-07-28
DE69000248D1 (de) 1992-09-17
AU5349990A (en) 1990-10-09
HU902883D0 (en) 1991-12-30
KR920700667A (ko) 1992-08-10

Similar Documents

Publication Publication Date Title
DK0387701T3 (da) Anvendelse af intercellulære adhæsionsmolekyler samt deres bindende ligander ved behandling af astma
NL192377B (nl) Werkwijze ter vervaardiging van spaan- of vezelplaten,alsmede vloeibaar concentraat te gebruiken bij de vervaardiging hiervan.
BR9000591A (pt) Compostos,processo para prepara-los,composicao,fungcida e processo para combater fungos
DE3853176D1 (de) Behandeln von Materialien.
ATE198895T1 (de) Verwendung von bindungsreagenzien gegen cd23 in der behandlung von autoimmunkrankheiten
BR8801004A (pt) Laminado retro-refletor,processo para produzir o mesmo e composicao de-revestimento
DE69819360D1 (de) Neue psoralene zur inaktivierung von pathogenen
FI881976A7 (fi) Seokset ja menetelmät puutavaran käsittelemiseksi.
DE3765393D1 (de) Brenner zur regenerierung von partikelfiltern.
DE3881967D1 (de) Verwendung von wasserloeslichen alkydharzen als bindemittel in wasserverduennbaren streichlacken.
DE3887861D1 (de) Vewendung von Aminen als Wärmestabilisierungsmittel in Organosiloxanzusammen-setzungen.
DE68913766D1 (de) Verwendung von nichtfarbigen lösungen zur desoxidation von aluminiumlegierungen.
BR8803254A (pt) Catalisador,processo para preparacao do mesmo bem como sua utilizacao em hidro-refinacao de fracoes de hidrocarbonetos
DE69002903D1 (de) Verfahren zur Erniedrigung des Benzolgehaltes von Benzinen.
FI875467A7 (fi) DNA-molekyylit, jotka ovat hyödyllisiä kasviensuojelussa.
NO901212L (no) Intracellulaere adhesjonsmolekyler og deres bindingsligander.
DE3777022D1 (de) Verfahren und praeparat zur inaktivierung von viren.
DE3764250D1 (de) Werkstuecktisch zum anbau von handkreissaegen.
DE69015098D1 (de) Verfahren zur Haloethylierung von aromatischen Kohlenwasserstoffen.
DE3578809D1 (de) Verfahren zum glaetten des blattes von mokassinen und vorrichtung dafuer.
FR2612123B1 (fr) Jaquette-enveloppe pour livres, brochures ou analogue
DE3860265D1 (de) Neue triazolopyrimidine und ihre verwendung als initiatoren.
ES487436A2 (es) Perfeccionamientos introducidos en los mecanismos de susten-tacion,plegado y deslizamiento de elementos colgantes
RU97102266A (ru) Средство для лечения облученных млекопитающих
ATE68742T1 (de) Zusammensetzungen, bestimmt zur holzbehandlung und verfahren zur holzbehandlung.