DK0384769T3 - Mærkning af proteiner - Google Patents
Mærkning af proteinerInfo
- Publication number
- DK0384769T3 DK0384769T3 DK90301949.5T DK90301949T DK0384769T3 DK 0384769 T3 DK0384769 T3 DK 0384769T3 DK 90301949 T DK90301949 T DK 90301949T DK 0384769 T3 DK0384769 T3 DK 0384769T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- bifunctional
- conjugates
- hydrazine
- metal ions
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000002372 labelling Methods 0.000 title 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 4
- 230000001588 bifunctional effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229920002521 macromolecule Polymers 0.000 abstract 3
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- -1 alkyl hydrazone Chemical class 0.000 abstract 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Paints Or Removers (AREA)
- Manufacture Of Metal Powder And Suspensions Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31527089A | 1989-02-24 | 1989-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0384769T3 true DK0384769T3 (da) | 1996-05-13 |
Family
ID=23223639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90301949.5T DK0384769T3 (da) | 1989-02-24 | 1990-02-23 | Mærkning af proteiner |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0384769B1 (de) |
| JP (1) | JP3073997B2 (de) |
| KR (1) | KR0142079B1 (de) |
| AT (1) | ATE137219T1 (de) |
| AU (1) | AU630668B2 (de) |
| CA (1) | CA2010800C (de) |
| DE (1) | DE69026637T2 (de) |
| DK (1) | DK0384769T3 (de) |
| ES (1) | ES2085890T3 (de) |
| FI (1) | FI95907C (de) |
| GR (1) | GR3019758T3 (de) |
| HU (1) | HU207293B (de) |
| IE (1) | IE74849B1 (de) |
| IL (1) | IL93432A (de) |
| NO (1) | NO178186C (de) |
| NZ (2) | NZ232656A (de) |
| PT (1) | PT93264B (de) |
| ZA (1) | ZA901283B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5589576A (en) * | 1989-08-29 | 1996-12-31 | Amersham International Plc | Cores for technetium radiopharmaceuticals |
| US6001979A (en) * | 1989-08-29 | 1999-12-14 | Nycomed Amersham Plc | Cores for technetium radiopharmaceuticals |
| US5296599A (en) * | 1991-09-19 | 1994-03-22 | Millipore Corporation | Activated carbamates compounds |
| GB9209641D0 (en) * | 1992-05-02 | 1992-06-17 | Johnson Matthey Plc | Improvements in radiolabelling |
| GB9223168D0 (en) * | 1992-11-05 | 1992-12-16 | Johnson Matthey Plc | Improvements in molecule labelling |
| US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
| DE69408145T2 (de) * | 1993-07-19 | 1998-09-03 | Resolution Pharm Inc | Hydrazine mit einer n3s konfiguration als radionukleide chelatoren |
| US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
| US7102024B1 (en) | 2000-08-01 | 2006-09-05 | Schwartz David A | Functional biopolymer modification reagents and uses thereof |
| US6686461B1 (en) | 2000-03-22 | 2004-02-03 | Solulink Bioscience, Inc. | Triphosphate oligonucleotide modification reagents and uses thereof |
| WO2001070685A2 (en) | 2000-03-22 | 2001-09-27 | Solulink, Incorporated | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| EP1877099B1 (de) | 2005-04-06 | 2012-09-19 | Genzyme Corporation | Therapeutische konjugate beinhaltend ein lysosomales enzym, polysialinsäure und eine zielkomponente |
| DK2457920T3 (en) | 2007-01-18 | 2018-01-22 | Genzyme Corp | Oligosaccharides comprising an amino oxy group and conjugates thereof |
| US8835614B2 (en) | 2008-12-16 | 2014-09-16 | Genzyme Corporation | Oligosaccharide-protein conjugates |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57181058A (en) * | 1981-04-30 | 1982-11-08 | Ikeda Mohandou:Kk | Compound labeled with 99m technetium, and its preparation |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
| US5066490A (en) * | 1988-06-01 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Protein crosslinking reagents cleavable within acidified intracellular vesicles |
-
1990
- 1990-02-19 IL IL9343290A patent/IL93432A/en not_active IP Right Cessation
- 1990-02-20 ZA ZA901283A patent/ZA901283B/xx unknown
- 1990-02-20 KR KR1019900002035A patent/KR0142079B1/ko not_active IP Right Cessation
- 1990-02-22 AU AU50074/90A patent/AU630668B2/en not_active Expired
- 1990-02-22 NO NO900838A patent/NO178186C/no not_active IP Right Cessation
- 1990-02-23 FI FI900948A patent/FI95907C/fi active IP Right Grant
- 1990-02-23 NZ NZ232656A patent/NZ232656A/en unknown
- 1990-02-23 AT AT90301949T patent/ATE137219T1/de not_active IP Right Cessation
- 1990-02-23 ES ES90301949T patent/ES2085890T3/es not_active Expired - Lifetime
- 1990-02-23 PT PT93264A patent/PT93264B/pt active IP Right Grant
- 1990-02-23 EP EP90301949A patent/EP0384769B1/de not_active Expired - Lifetime
- 1990-02-23 IE IE66690A patent/IE74849B1/en not_active IP Right Cessation
- 1990-02-23 DK DK90301949.5T patent/DK0384769T3/da active
- 1990-02-23 HU HU90970A patent/HU207293B/hu unknown
- 1990-02-23 NZ NZ239288A patent/NZ239288A/en unknown
- 1990-02-23 JP JP02041389A patent/JP3073997B2/ja not_active Expired - Fee Related
- 1990-02-23 CA CA002010800A patent/CA2010800C/en not_active Expired - Lifetime
- 1990-02-23 DE DE69026637T patent/DE69026637T2/de not_active Expired - Lifetime
-
1996
- 1996-04-25 GR GR960400832T patent/GR3019758T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT53600A (en) | 1990-11-28 |
| NO900838D0 (no) | 1990-02-22 |
| EP0384769B1 (de) | 1996-04-24 |
| DE69026637D1 (de) | 1996-05-30 |
| PT93264B (pt) | 1996-01-31 |
| ZA901283B (en) | 1991-03-27 |
| AU630668B2 (en) | 1992-11-05 |
| ATE137219T1 (de) | 1996-05-15 |
| FI95907C (fi) | 1996-04-10 |
| EP0384769A2 (de) | 1990-08-29 |
| EP0384769A3 (de) | 1991-11-27 |
| JP3073997B2 (ja) | 2000-08-07 |
| HU207293B (en) | 1993-03-29 |
| GR3019758T3 (en) | 1996-07-31 |
| NZ232656A (en) | 1992-04-28 |
| IE74849B1 (en) | 1997-08-13 |
| NO178186B (no) | 1995-10-30 |
| ES2085890T3 (es) | 1996-06-16 |
| NO178186C (no) | 1996-02-07 |
| IE900666L (en) | 1990-08-24 |
| HU900970D0 (en) | 1990-05-28 |
| FI95907B (fi) | 1995-12-29 |
| KR0142079B1 (ko) | 1998-06-01 |
| NZ239288A (en) | 1992-04-28 |
| PT93264A (pt) | 1990-08-31 |
| NO900838L (no) | 1990-08-27 |
| AU5007490A (en) | 1990-09-13 |
| CA2010800A1 (en) | 1990-08-24 |
| CA2010800C (en) | 2001-01-16 |
| JPH0327356A (ja) | 1991-02-05 |
| KR900012910A (ko) | 1990-09-03 |
| IL93432A (en) | 1994-02-27 |
| FI900948A0 (fi) | 1990-02-23 |
| DE69026637T2 (de) | 1996-09-26 |
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