DK0378382T3 - Rekombinant DNA-fremgangsmåde og værtsceller - Google Patents

Rekombinant DNA-fremgangsmåde og værtsceller

Info

Publication number
DK0378382T3
DK0378382T3 DK90300270.7T DK90300270T DK0378382T3 DK 0378382 T3 DK0378382 T3 DK 0378382T3 DK 90300270 T DK90300270 T DK 90300270T DK 0378382 T3 DK0378382 T3 DK 0378382T3
Authority
DK
Denmark
Prior art keywords
host cells
recombinant dna
dna method
amount
transcription unit
Prior art date
Application number
DK90300270.7T
Other languages
Danish (da)
English (en)
Inventor
Mark Ian Cockett
Christopher Robert Bebbington
Geoffrey Thomas Yarranton
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Ltd filed Critical Celltech Ltd
Application granted granted Critical
Publication of DK0378382T3 publication Critical patent/DK0378382T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK90300270.7T 1989-01-10 1990-01-10 Rekombinant DNA-fremgangsmåde og værtsceller DK0378382T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898900483A GB8900483D0 (en) 1989-01-10 1989-01-10 Recombinant dna method

Publications (1)

Publication Number Publication Date
DK0378382T3 true DK0378382T3 (da) 1997-06-16

Family

ID=10649831

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90300270.7T DK0378382T3 (da) 1989-01-10 1990-01-10 Rekombinant DNA-fremgangsmåde og værtsceller

Country Status (12)

Country Link
US (2) US5866359A (fr)
EP (1) EP0378382B1 (fr)
JP (1) JP3070950B2 (fr)
AT (1) ATE153382T1 (fr)
AU (2) AU4825390A (fr)
CA (1) CA2024607C (fr)
DE (1) DE69030740T2 (fr)
DK (1) DK0378382T3 (fr)
ES (1) ES2103266T3 (fr)
GB (1) GB8900483D0 (fr)
GR (1) GR3024002T3 (fr)
WO (1) WO1990008191A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8900483D0 (en) 1989-01-10 1989-03-08 Celltech Ltd Recombinant dna method
EP0455424A3 (en) * 1990-05-02 1992-04-29 Merck & Co. Inc. Mammalian inducible promoter cascade system
CA2047633A1 (fr) * 1990-09-12 1992-03-13 Ben Bowen Inactivation de la traduction genetique che les plantes au moyen d'activateurs modifies de la traduction
DK0566554T3 (da) * 1992-03-13 2000-08-07 Monsanto Co Fremstilling af rekombinante proteiner ved anvendelse af herpesviruspromotorer og VP16-transaktivatorer
US5585237A (en) * 1993-10-25 1996-12-17 Creative Biomolecules, Inc. Methods and compositions for high protein production from recombinant DNA
US5631158A (en) * 1993-10-25 1997-05-20 Creative Biomolecules, Inc. Methods and compositions for high protein production from non-native DNA
ES2333425T5 (es) 1995-06-15 2012-08-28 Crucell Holland B.V. Sistemas de empaquetado para adenovirus recombinante humano destinados a terapia génica
US8236561B2 (en) * 1999-04-15 2012-08-07 Crucell Holland B.V. Efficient production of IgA in recombinant mammalian cells
US7604960B2 (en) * 1999-04-15 2009-10-20 Crucell Holland B.V. Transient protein expression methods
SI1533380T1 (sl) * 1999-04-15 2010-03-31 Crucell Holland Bv Proizvajanje rekombinantnega proteina v človeški celici ki obsega vsaj en protein E adenovirusa
US20050170463A1 (en) * 1999-04-15 2005-08-04 Abraham Bout Recombinant protein production in permanent amniocytic cells that comprise nucleic acid encoding adenovirus E1A and E1B proteins
US20050164386A1 (en) * 1999-04-15 2005-07-28 Uytdehaag Alphonsus G. Overexpression of enzymes involved in post-translational protein modifications in human cells
WO2003048348A2 (fr) * 2001-12-07 2003-06-12 Crucell Holland B.V. Production de virus, d'isolats viraux et de vaccins
US6855544B1 (en) * 1999-04-15 2005-02-15 Crucell Holland B.V. Recombinant protein production in a human cell
US7297680B2 (en) * 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
US7192759B1 (en) * 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
US7521220B2 (en) * 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
US7527961B2 (en) * 1999-11-26 2009-05-05 Crucell Holland B.V. Production of vaccines
MXPA03010626A (es) * 2001-05-30 2004-12-06 Chromos Molecular Systems Inc Plataformas a base de cromosomas.
WO2004099396A1 (fr) 2003-05-09 2004-11-18 Crucell Holland B.V. Cultures de cellules immortalisees par e1 et procedes de culture de ces dernieres visant a en augmenter les rendements de produits
EP1626992B1 (fr) * 2003-05-23 2010-06-02 Crucell Holland B.V. Production d'une igm recombinante dans des cellules per.c6
WO2005065348A2 (fr) 2003-12-31 2005-07-21 Kalobios, Inc. Systeme de transactivation de cellules mammaliennes
EP2711426B1 (fr) 2012-09-24 2015-04-08 Lonza Biologics plc Vecteurs d'expression comprenant des séquences chimériques de promoteur et amplificateur de cytomégalovirus
EP2829608A1 (fr) 2013-07-23 2015-01-28 Universität Bielefeld Procédé de production de protéine recombinante dans des cellules de mammifères

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
EP0245949B1 (fr) * 1986-04-09 1997-10-29 Eli Lilly And Company Méthode d'utilisation des vecteurs d'expression eucaryotiques comportant les séquences stimulantes du virus BK
US4775630A (en) * 1986-08-15 1988-10-04 Vanderbilt University Transcriptional control element adapted for regulation of gene expression in animal cells
EP0282330A3 (fr) * 1987-03-13 1988-11-09 Schering Corporation Procédé pour stimuler l'expression de gènes
US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
GB8900483D0 (en) 1989-01-10 1989-03-08 Celltech Ltd Recombinant dna method

Also Published As

Publication number Publication date
AU662416B2 (en) 1995-08-31
AU4825390A (en) 1990-08-13
AU3994193A (en) 1993-08-12
GR3024002T3 (en) 1997-10-31
US6653101B1 (en) 2003-11-25
US5866359A (en) 1999-02-02
JPH03503959A (ja) 1991-09-05
CA2024607A1 (fr) 1990-07-11
DE69030740D1 (de) 1997-06-26
ES2103266T3 (es) 1997-09-16
WO1990008191A1 (fr) 1990-07-26
GB8900483D0 (en) 1989-03-08
DE69030740T2 (de) 1997-11-27
CA2024607C (fr) 1999-11-30
JP3070950B2 (ja) 2000-07-31
EP0378382A1 (fr) 1990-07-18
ATE153382T1 (de) 1997-06-15
EP0378382B1 (fr) 1997-05-21

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