DEP0037076DA - Drying of heat-sensitive materials - Google Patents
Drying of heat-sensitive materialsInfo
- Publication number
- DEP0037076DA DEP0037076DA DEP0037076DA DE P0037076D A DEP0037076D A DE P0037076DA DE P0037076D A DEP0037076D A DE P0037076DA
- Authority
- DE
- Germany
- Prior art keywords
- heat
- drying
- sensitive materials
- substances
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001035 drying Methods 0.000 title claims description 8
- 239000000463 material Substances 0.000 title description 3
- 239000000126 substance Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
Description
FARlEliFABRIKEl BAYERFARlEliFABRIKEl BAYER
l&PARBENINDUSTffiE ΑΛ3.ΙΝ AUFLÖSUNG / IN DISSOLUTION (UNDER BRITISH CONTROL)l & PARBI INDUSTRY ΑΛ3.ΙΝ DISSOLUTION / IN DISSOLUTION (UNDER BRITISH CONTROL)
Leverkusen, den 9.5.50Leverkusen, 9.5.50
FB/WiFB / Wi
Trocknung wärmeempfindlicher StoffeDrying of heat-sensitive materials
Die vorliegende Erfindung betrifft ein Verfahren zur Trocknung wärmeempfindlicher Stoffe unter Verwendung der Gefriertrooknunge The present invention relates to a method for drying heat-sensitive materials using the Gefriertrooknung e
Die Gefriertrocknung wird in neuerer Zeit häufig angewendet insbesondere bei solchen Stoffen, die bei Temperaturen oberhalb von O0C empfindlich sind* Pharmazeutische Produkte wie Penicillin und Blutplasma oder Proteine werden auf diesem Wege in schonendster Weise getrocknet. Das Verfahren besteht darin, dass die Trocknung, also Sublimation von Sis aus dem gefrorenen Produkt bei Drucken von 0,1 Torr und weniger vorgenommen wird. Die zur Trocknung notwendige Verdampfungswärme des lassers wird hierbei meistens durch Wärmestrahlung dem zu trocknenden Körper zugeführt. Die Wellenlänge des Wärme Strahlers wird möglichst so gewählt,, dass vor allem Wasser oder Eis diese Wellenlänge absorbiert und dass die zu trocknende Substanz möglichst wenig von den ankommenden Strahlen in Wärme umwandelt. Hun gibt es aber Substanzen, deren Absorptionsmaxima bei Wellenlängen liegen, die auch vom Wasser stark absorbiert werden. Solche Substanzen sind daher durch örtliche Erhitzungen stark gefährdet.Freeze-drying has recently been used frequently, especially for substances that are sensitive to temperatures above 0 ° C. * Pharmaceutical products such as penicillin and blood plasma or proteins are dried in the most gentle way in this way. The method consists in that the drying, i.e. sublimation of Sis from the frozen product, is carried out at pressures of 0.1 Torr and less. The heat of evaporation of the lassers necessary for drying is mostly supplied to the body to be dried by thermal radiation. The wavelength of the heat radiator is chosen so that, above all, water or ice absorbs this wavelength and that the substance to be dried converts as little as possible of the incoming rays into heat. But there are substances whose absorption maxima are at wavelengths that are also strongly absorbed by water. Such substances are therefore at great risk from local heating.
Bs ist bekannt, dass durch dielektrische Hochfrequenzheizung fässer oder Sis aufgeheizt werden kann. Aus diesem Grunde hat man die Hochfrequenzheizung angewendet',', um in Getreidesilos Lagersciridlinge zu töten. Der Vorgang beruht darauf, dass die stark wasserhaltigen Lebewesen durch die heizung sehr viel stärker erhitzt werden als die erheblich wasserarmeren Getreidekörner.It is known that high-frequency dielectric heating can heat up barrels or sis. This is why you have the High frequency heating applied ',' to kill camp sciridlings in grain silos. The process is based on the fact that the highly water-containing Living beings are heated much more strongly by the heating than the grain grains, which are considerably less watery.
Es wurde nun ein eingangs erwähntes Verfahren zur Trocknung wärmeempfindlicher Stoffe gefunden, das gemäss der Erfindung darinA method for drying mentioned at the beginning has now become more heat-sensitive Substances found according to the invention therein
Le A 129Le A 129
besteht, dass dem im gefrorenen Zustand befindlichen Gut die zur Verdampfung des im Gut enthaltenen Eises9 bzw. Wassers erforderliche Wärme durch Hochfrequenzbestrahlung zugeführt wird. Nach dem oben Ausgeführten ist es ausserordentlich überraschend, dass bei diesem Verfahren die zu trocknenden wärmeempfindlichen Stoffe nicht durch die Hochfrequenzheizung geschädigt werden; es wllre zu erwarten gewesen, dass diese Stoffe, da sie im Wasser gelöst oder als kolloide Substanz selbst sehr viel lasser enthalten, durch die vom Wasser aufgenommene warme zerstört worden wären«consists in that the goods located in the frozen state are supplied with the heat required for evaporation of the ice 9 or water contained in the goods by high-frequency irradiation. According to what has been said above, it is extremely surprising that in this process the heat-sensitive substances to be dried are not damaged by the high-frequency heating; it wllre have been expected that these substances since they dissolved in the water or as a colloidal substance itself very much included lasser, had been destroyed by the water taken warm "
Das neue Verfahren ist allgemein anwendbar, insbesondere zum Trocknen von Penicillin und ähnlichen Stoffen»The new process is generally applicable, especially for drying penicillin and similar substances »
Claims (1)
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE4009157C2 (en) | Method and device for the hydro-thermal treatment of rice | |
| DE2911549A1 (en) | THICK LAYER CONTACT DRYER | |
| EP2330370A2 (en) | Belt drying with efficient heating | |
| DEP0037076DA (en) | Drying of heat-sensitive materials | |
| DE825671C (en) | Drying of heat-sensitive materials | |
| CH684507A5 (en) | A method for processing radioactive waste. | |
| DE2729015C3 (en) | Post-drying of hops | |
| DE1454843B2 (en) | PROCESS FOR CONTINUOUS DRYING OF CORES MADE FROM POLYAETHYLENE TEREPHTHALATE | |
| DE19721707C2 (en) | Process for drying paper | |
| EP0199092A1 (en) | Process for the accelerated fixation of chromate-containing wood preservative salts | |
| DD146846A1 (en) | METHOD FOR DRYING COFFEE FRUITS IN A BAY DRYER | |
| DE2038310C3 (en) | Process and device for the continuous production of pure and dry carboxymethyl cellulose | |
| DE1604889C3 (en) | Method and device for drying plastic granulate | |
| DE1767307A1 (en) | Process for agglomeration and subsequent granulation of fines | |
| DE971397C (en) | Method and device for drying leather | |
| DE207724C (en) | ||
| DE3815683C2 (en) | ||
| DE2401809C3 (en) | Process for dewatering comminuted, moisture and sugar-containing material, in particular cattle feed granulate, and device for carrying out the process | |
| DE1923249A1 (en) | Process for dewatering heat-sensitive, solid materials | |
| DE3602464A1 (en) | Process and apparatus for the continuous puffing and flash drying of foods | |
| DE335406C (en) | Process for the sterilization of flour and semolina made from grains | |
| DE701802C (en) | Process to improve the water resistance of brown coal briquettes | |
| DE306464C (en) | ||
| DE461534C (en) | Method for obtaining the seeds from the cones of conifers | |
| DE739770C (en) | Process for the pretreatment of vegetable matter containing tannin intended for extraction |