DEP0032286DA - Process for the preparation of nucleosides by hydrolysis of nucleic acid - Google Patents
Process for the preparation of nucleosides by hydrolysis of nucleic acidInfo
- Publication number
- DEP0032286DA DEP0032286DA DEP0032286DA DE P0032286D A DEP0032286D A DE P0032286DA DE P0032286D A DEP0032286D A DE P0032286DA
- Authority
- DE
- Germany
- Prior art keywords
- hydrolysis
- nucleosides
- preparation
- nucleic acid
- öureii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims 3
- 230000007062 hydrolysis Effects 0.000 title claims 2
- 238000006460 hydrolysis reaction Methods 0.000 title claims 2
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 239000002253 acid Substances 0.000 description 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 208000034656 Contusions Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
Description
7 feb. IB 7 feb. IB
u.IK tlÄ£BH0i* ü^ainlieim«>\?uli3hcif, 25, 2, 1950u.IK tlÄ £ BH0i * ü ^ ainlieim «> \? uli3hcif , 25, 2, 1950
Hanna el»«- tTaMliof 1 §/ΐΆ */W ·Hanna el »« - tTaMliof 1 § / ΐΆ * / W ·
«cd? Herstellung ψοιι facleosiiea dar oil Bjrdrolyse von lucleinsäure."CD? Production of ψοιι facleosiiea dar oil Bjrdrolysis of lucleic acid.
§e-filaanii.g von ittüleosMea durch hydrolytiöühö Spaltung§E-filaanii.g of ittüleosMea by hydrolytiöühö cleavage
ifaoleiaaäiare Itami huoIl bekaiititea Terfairea durch 3-"bis 4 sätiiÄÜgt Beiiaaöliiag Jiit liiaoniafc "bei 175 ^ia ISO0 erfolge»» lias erhält hierbei ein Seaiscli der Purin- und lyriaiilaiittcleoside. ifaoleiaaäiare Itami huoIl bekaiititea Terfairea by 3 "to 4 sätiiÄÜgt Beiiaaöliiag Jiit liiaoniafc" at 175 ^ ia ISO 0 successes »» lias receives a seaiscli of the purine and lyriaiilaiittcleoside.
lachteilig bei iieseai ferfahrea ist, das »an eine schlechte Aasbeate erhält und in Brucfcgefäßen arbeiten boJ« Arbeitet aar unter milderen. Bedingungen» 2*1« bei 115 » so wird die luoleii säure nmr bis za ti en Mononacleotiden a"bgel>aate The disadvantage of iieseai ferfahrea is that "gets a bad carrion and works in bruising vessels" works aar under milder ones. Conditions »2 * 1« at 115 »then the luoleii acid nmr to za ti en Mononacleotiden a"bgel> aat e
hat daher («iWtsche Batentsciirift 693 416) die Verwendunghas therefore («iWtsche Batentsciirift 693 416) the use
flüchtiger organischer Basen, wie SyrMiii* Okiaolin asi?e,vor-gesöMagea» wobei die Spaltung der Itieleiasäare ia etwa 96 Standen, beendet ist. Die Ausbeute aa S-maaosin anä Aätaosin ist wesentlioli besser als Isei Verwendung von Aßvolatile organic bases, such as SyrMiii * Okiaolin asi? e , vor-gesöMagea »whereby the split of the Itieleiasäare generally about 96 stands has ended. The yield aa S-maaosin anä Aätaosin is much better than when using Aß
la \mrde aan überraschenderv?eise gefunden, dig afm die Spal» taag der lucleinsäure in vorteilhafter Heise auch ait wasserlöslichen aojolisckea oier cyclischen Ithern durchftäihren kann» Beia Eochea der Huoleinsäure mit solchen Lösungen findet eine glatte Abspaltung ait IhQspttoräste statt« Die Reaktion verläuft aciaaeller als "bei Psriiia^aai ti® verwendeten Reagenzien sind wesentlich wohlfeiler.It was surprisingly found that after the split day of lucleic acid can also be carried out in an advantageous manner with water-soluble aojolisckea or cyclic ethers, "In the case of huoleic acid with such solutions, a smooth splitting off with IhQ late branches takes place" The reaction takes place than "reagents used in Psriiia ^ aai ti® are much cheaper.
Claims (1)
100 g koIiiiacioLiuaure iier-i©2x ,rät 2 'j'ä ccä rOios^ü Uüd 4^-3 oosiexample
100 g koIiiiacioLiuaure iier-i © 2x, advises 2 'j'ä ccä rOios ^ ü Uüd 4 ^ -3 oosi
oään 10 g und aa Aienosia 8 g9 sieIi bsircüiiiten Verfairr en Ailenosiii aircfet i'ic * .; iuB.ea «. Aasb oute
oään 10 g and aa Aienosia 8 g 9
Stieleiatiäure. daätti'C/i ^elceuuacielaiel», daä Juan die Ilacleiaaüure ait/vjaaserlösliciiea. acycliooiien oder, oyoliscliea Atkera;: erhitzt woäorcLi die !laoleosiile in Preüieit sesetst v/erden.Process for the production of lucleosiänen öureii hydrolysis of
Stieleiatiäure. daätti'C / i ^ elceuuacielaiel », daä Juan the Ilacleiaaüure ait / vjaaserlösliciiea. acycliooiien or, oyoliscliea Atkera ;: heated woäorcLi the! laoleosiile in Preüieit sesetst v / ground.
Family
ID=
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