DEP0023241DA - - Google Patents
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- Publication number
- DEP0023241DA DEP0023241DA DEP0023241DA DE P0023241D A DEP0023241D A DE P0023241DA DE P0023241D A DEP0023241D A DE P0023241DA
- Authority
- DE
- Germany
- Prior art keywords
- isomers
- crystals
- separated
- liquid
- pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- 239000013078 crystal Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 3
- 238000005660 chlorination reaction Methods 0.000 claims description 2
- 229960002809 lindane Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N Glycolaldehyde Chemical compound OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- JLYXXMFPNIAWKQ-GNIYUCBRSA-N gamma-hexachlorocyclohexane Chemical compound Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl JLYXXMFPNIAWKQ-GNIYUCBRSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Description
FÜR CHEMISCH-PHARMAZEUTISCHE PRÄPARATE M.B.H. DUSSELDORF-GERRESHEIM . VENNHAUSER ALLEE 242 FOR CHEMICAL-PHARMACEUTICAL PREPARATIONS MBH DUSSELDORF-GERRESHEIM. VENNHAUSER ALLEE 242
Γ HΓ H
•j.. Fernruf: 691004/7 Bankverbindung:• j .. remote call: 691004/7 bank details:
nmtBChm BrteUtnt, Postscheckkonto: Essen 38957 nmtBChm BrteUtnt, postal check account: Essen 38957
(1pb) « ü η c h e ü 26·(1pb) «ü η c h e ü 26 ·
Deutsche© Museum.German © Museum.
L JL J
232*1 TT e/ 12 6 2Jr*Iu«/£. SuSept.232 * 1 TT e / 12 6 2Jr * Iu «/ £. SuSept.
''l/erfahren zur Isolierung von '' l / experienced in isolating reinem Ϊ-nexachlorcyclohexan1'.pure Ϊ-nexachlorocyclohexane 1 '.
Bei dem darch Chlorierung von Benzol gewonnenen Hexachlarcyclohexanprodukt 1st das /- Isomere wegen seiner stark Insektiziden virkung besonders wertvoll. Is ist aber sehr schwierig, «las ^-Hexachlorcyclohexan von den anderen unwirksamen Isonieren zu treimen. LIe be~ icaanten Verfahren» eile sich auf die verschiedenen Löslichkeiten der einzeliieö Ißoae3?©G i,n organischen LÖsuBgsjaittf^Liit wdLe Alkohol § öhloroform, Benzol ns«· stunden, arbeiten nicht aafriedenöteilend, da imraer größere Meagen dar anderen leomeren, ύ±& ähnliciie Löslichkeit en Ie verschiedenen LtisangsiaittelnIn the hexachlarcyclohexane product obtained by chlorination of benzene, the / isomer is particularly valuable because of its strong insecticidal effect. It is very difficult, however, to separate the ^ -hexachlorocyclohexane from the other ineffective isonates. LIe be ~ icaant processes "hurry to the different solubilities of the individual oleomers3? © G i, n organic soluons - liit wdLe alcohol § oleoroform, benzene ns" · hours, do not work as a resultant, since larger amounts of the other leomers, ύ ± & Similar solubilities in different solvents
Insbeoondere gelingt es auf diese Weise nicht, die Trenriuiig i-ilexachlorcyclohexanß aus dem Gemisch der anderen Isomeren in be~ friedigeader ..eise herbeizuführen.In particular, the Trenriuiig i-ilexachlorcyclohexanß from the mixture of the other isomers in be ~ peace leader ..is to bring about.
Die ^rUndaag seigt einen '^eg, dieses Ziel la des* ;iaaptsache ahn© AnweiiduriB von Lösungsmitteln zu erreicheti. iüne v.dchtige Voraussetzung für das GeÜJä^n See erflGdan.gsgesiäß®ü Terfahrehs ist der lDsungsisittelfreie ZustaM der ein@eBet2ten Heatachlorcyclohexanlösung. äaa destilliert daher zunächst ans der Losung das In Ihr enthaltene anverändert© Benaol und die durch öubtitution entstandenen Chlorbeneole ab und läßt erkalten. Hierbei fällt eine große Kristalle &m der Lösung aus. T<ach ierlileinerung der Kristall* v,ird diese auf etwa 60 - 00° erhitzt and von den ungelöstenThe ^ rUndaag see a '^ eg to achieve this goal la des *; iaaptsache ahn © AnweiiduriB of solvents. One of the most important prerequisites for the GeÜJä ^ n See erflGdan.gsgesiäß®ü Terfahrehs is the solvent-free condition of the one @ eBet2ten Heatachlorcyclohexanlösung. äaa therefore first distills from the solution the modified Benaol contained in it and the chlorobeneols resulting from substitution and allows it to cool. Here, a large crystals & falls from m the solution. After cleaning the crystal, it is heated to about 60 - 00 ° and the undissolved
abgeschleudert. Me Masse teilt sieh hierbei la einenthrown off. My mass divides you see here la one
ungelösten Bxistallkuchen, der sich la der Hauptsache aus Isosierenundissolved crystal cake, which is mainly made up of isosing
Claims (1)
Family
ID=
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