DE948005C - Process for the fractional separation of B-type and B-type vitamins from solutions using ion exchangers - Google Patents
Process for the fractional separation of B-type and B-type vitamins from solutions using ion exchangersInfo
- Publication number
- DE948005C DE948005C DEF3106D DEF0003106D DE948005C DE 948005 C DE948005 C DE 948005C DE F3106 D DEF3106 D DE F3106D DE F0003106 D DEF0003106 D DE F0003106D DE 948005 C DE948005 C DE 948005C
- Authority
- DE
- Germany
- Prior art keywords
- type
- solutions
- vitamins
- ion exchangers
- fractional separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Description
Verfahren zur fraktionierten Trennung von Vitaminen des B1-Typs und des B2-Typs aus Lösungen unter Verwendung von Ionenaustauschern Es wurde gefunden, daß eine fraktionierte Abtrennung von Vitaminen des B1-Typs und des B2-Typs aus Lösungen gelingt, wenn man dieselben zunächst mit Anionenaustauschern und anschließend mit Wasserstoffionenaustauschern behandelt. Die Anionenaustauscher können dabei mit Hydroxyl- oder Säureanionen beladen sein, während die Kationenaustauscher entweder direkt als Wasserstoffionenaustauscher eingesetzt werden oder eine entsprechende Umstellung gegebenenfalls durch die von Natur sauren oder künstlich angesäuerten vitaminhaltigen Lösungen erfahren. Als Ionenaustauscher können die bekannten Produkte, besonders solche auf Kunstharzgrundlage, verwendet werden. Sie werden entweder in nacheinandergeschalteten Filtern angeordnet oder entsprechend in die Flüssigkeiten eingerührt.Process for the fractional separation of vitamins of the B1 type and of the B2 type from solutions using ion exchangers It was found, that a fractional separation of vitamins of the B1-type and the B2-type Solutions succeed if you first use anion exchangers and then treated with hydrogen ion exchangers. The anion exchangers can thereby be loaded with hydroxyl or acid anions, while the cation exchangers are either can be used directly as a hydrogen ion exchanger or a corresponding one If necessary, switch to the naturally acidic or artificially acidified ones experience vitamin-containing solutions. The known products, especially those based on synthetic resin can be used. You will either be in successively arranged filters or correspondingly in the liquids stirred in.
Bei der Arbeitsweise gemäß der Erfindung werden die Vitamine des B2-Typs durch die Anionenaustauscher, die Vitamine des Bl-Typs durch die Kationenaustauscher gebunden. Die Regenerierung erfolgt im ersten Falle entweder durch Lösungsmittel, wie Pyridin, Methanol, Eisessig oder deren gegebenenfalls auch wasserhaltigen Gemische, oder mit in Wasser gelösten Reduktionsmitteln, wie Natriumhydrosulfit, im zweiten Falle mit Lösungen von Elektrolyten, wie Kochsalz, Salzsäure od. dgl. When working according to the invention, the vitamins are des B2 type through the anion exchanger, the vitamins of the B1 type through the cation exchanger bound. The regeneration takes place in the first case either by solvents, such as pyridine, methanol, glacial acetic acid or their optionally also water-containing mixtures, or with reducing agents dissolved in water, such as sodium hydrosulfite, in the second case with solutions of electrolytes such as table salt, hydrochloric acid or the like.
Beispiel Über ein Aggregat aus je einem mit einem Anionenaustauscher und einem mit einem Wasserstoffionenaustauscher gefüllten Filter wird eine Lösung filtriert, die im Liter 3000 r B1 und 5000 y B2 enthält. Der Kationenaustauscher ist ein Resorcin-Benzaldehyddisulfosäure - Formaldehyd - Kondensationsprodukt, der Anionenaustauscher ein Kondensationsprodukt aus m-Phenylendiamin, Polyäthylendiamin und Formaldehyd. Example using an assembly consisting of one each with an anion exchanger and a filter filled with a hydrogen ion exchanger becomes a solution filtered, which contains 3000 r B1 and 5000 y B2 per liter. The cation exchanger is a resorcinol benzaldehyde disulfonic acid - formaldehyde - condensation product, the Anion exchanger a condensation product of m-phenylenediamine, polyethylene diamine and formaldehyde.
Die Abläufe des ersten Filters, d. h. des Anionenaustauschers, enthalten kein Vitamin B2 mehr und sind daher farblos, das Vitamin B1 dagegen wird erst vom Kationenaustauscher aufgenommen. The operations of the first filter, i. H. of the anion exchanger no more vitamin B2 and are therefore colorless, the vitamin B1 on the other hand is only from Cation exchanger added.
Wenn die Filter erschöpft sind, regeneriert man nach dem Auswaschen. mit Wasser den Anionenaustauscher mit einem gegebenenfalls auf 500 C erwärmten Pyridin-Methanol-Wasser- oder Pyridin-Eisessig-Wasser-Gemisch und den Kationenaustauscher mit starker Salzsäure. Die Wiederbelebungsflüssigkeiten können dabei jeweils wiederholt verwendet werden, um die darin enthaltenen Wirkstoffe möglichst weitgehend anzureichen. When the filters are exhausted, they regenerate after washing. with water the anion exchanger with a pyridine-methanol-water- or pyridine-glacial acetic acid-water mixture and the cation exchanger with strong hydrochloric acid. The resuscitation fluids can be used repeatedly, in order to enrich the active ingredients contained therein as much as possible.
Es ist bekannt, daß man Vitamine aus Lösungen, wie z. B. Molke, mittels Aktivkohle oder Bleicherden anreichen kann. Die Adsorption ist jedoch unspezifisch, so daß man verschiedene Wirkstoffe nicht ohne weiteres trennen kann, und es werden bei dieser Arbeitsweise auch erhebliche Mengen von unerwünschten Begleitstoffen mit niedergeschlagen. It is known that vitamins can be obtained from solutions such. B. whey, means Activated charcoal or fuller's earth. However, the adsorption is unspecific, so that one cannot and will not easily separate different active substances in this way of working also considerable amounts of undesired accompanying substances with dejected.
Es ist ferner eine Analysenmethode zur Trennung der Vitamine B1 und B2 beschrieben worden, nach welcher die Lösungen der Vitamine über einen anorganischen Ionenaustauscher und anschließend über ein anorganisches Adsorptionsmittel geleitet werden. Dieses Verfahren unterscheidet sich grundlegend von dem beanspruchten Verfahren, da ersteres sich zur Adsorption des Vitamin B2 keines Anionenaustauschers und zur Adsorption des Vitamin B1 keines Wasserstoffionenaustauschers bedienen. It is also an analytical method for separating vitamins B1 and B2 has been described, according to which the solutions of the vitamins via an inorganic Ion exchanger and then passed over an inorganic adsorbent will. This method differs fundamentally from the claimed method, since the former is not an anion exchanger for the adsorption of vitamin B2 and for Do not use a hydrogen ion exchanger for adsorption of vitamin B1.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF3106D DE948005C (en) | 1944-12-01 | 1944-12-01 | Process for the fractional separation of B-type and B-type vitamins from solutions using ion exchangers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF3106D DE948005C (en) | 1944-12-01 | 1944-12-01 | Process for the fractional separation of B-type and B-type vitamins from solutions using ion exchangers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE948005C true DE948005C (en) | 1956-08-23 |
Family
ID=7083681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF3106D Expired DE948005C (en) | 1944-12-01 | 1944-12-01 | Process for the fractional separation of B-type and B-type vitamins from solutions using ion exchangers |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE948005C (en) |
-
1944
- 1944-12-01 DE DEF3106D patent/DE948005C/en not_active Expired
Non-Patent Citations (1)
| Title |
|---|
| None * |
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