DE927112C - Process for the production of an antibiotic silver-containing wound dressing powder - Google Patents

Description

Process for the production of an antibiotic silver-containing wound dressing powder Antibiotics, like penicillin, subtilin, and tyrothricin, show one primarily antibacterial effect on gram-positive germs. Mixed infected with local treatment Wounds with such antibiotic substances can reduce their effectiveness to grain-positive Pus pathogens impaired or abolished by the presence of grain-negative germs will.

For the simultaneous inhibition of the gram-negative germs, Konibinationspräparate manufactured in which z. B. an antibiotic with predominant Effect on gram positive. Germs, like the penicillin, along with one preferably antibiotic that inhibits gram-negative germs, such as your streptamvcin, is used got. Also the combination with non-antibiotic substances. z. B. Tvrothricin, with quaternary ammonium-1> aseii is known. While the quaternary @mmonium bunnies Wound preparations containing silver can lose their effectiveness through wound secretions well proven on secreting wounds. It is known that they are used for local wound treatment Germicidal silver preparations in powder form on an inorganic or organic basis.

The use of organic powder bases is also important for antibiotic wound powders, such as B. lactose, glucose and dry plasma are known.

The manufacture of an antibacterial wound powder on organic Basis using an antibiotic suitable for local treatment and Silver with simultaneous effect on gram-positive and gram-negative, ve germs Insofar as difficult, as the antibiotic required by the production Sill; ersalz inactivated will. Especially with the polypeptide-like ones Antibiotics subtilin and tyrothricin occurs through the silver salts a precipitation a.

The elimination of this disadvantage can be prevented according to the invention that an organic powder base is first impregnated with a silver salt solution and heated until practically no more silver ions can be detected, whereupon the silver-containing powder is treated with a solution of an antibiotic.

The processing can take place, for example, as follows: i o kg of powdered milk sugar, pectin, gelatine or their mixture will slow down Pre-drying to 14o ° C in the cooled state with that amount of a solution of silver nitrate in methanol added, that the amount of silver i0 / "to 20/9, in terms of value 30 / () () of the weight of the powder base. The powder composition containing silver nitrate is heated again to around 120 ° C until there are practically no silver ions are more detectable. After cooling, the powder mass is mixed with 10 g tyrothricin, dissolved in 1 kg of methanol, impregnated and dried.

Claims (5)

PATENT CLAIMS: i. Method of making an antibiotic silver-containing wound powder, characterized in that an organic powder base impregnated with a silver salt solution and heated until no silver ions more are detectable, whereupon the silver-containing powder with the solution of an antibiotic treated and dried. 2. The method according to claim i, characterized by the use of a powder base made from milk sugar, pectin or gelatine or a mixture of these substances. 3. The method according to claim i and a, characterized in that that the powder base prior to impregnation a slow pre-drying up to is subjected to about i ¢ o ° C .. q .. Method according to claims i to 3, characterized in that that a heating of the powder base impregnated with silver salt to about 120 ° C takes place. 5. The method according to claim i and 2, diadu.rch characterized in that a solution of tyrothricin or subtilnn is used as an antibiotic. Dressed Publications: v. Czetsch-Lindenwald, "Salben, Puder, Externa", 1950, p.385 ,. 3 $ 2, 376.