DE8623294U1 - Means for the application of transdermally absorbable active substances - Google Patents

Description

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Agent for the application of transdermally absorbable active substances

The subject of the present invention is a means for the application of transdermally absorbable active substances, which allows an intensive and long-lasting effect of the transdermally absorbable active substances and increases their effectiveness through the simultaneous effect of heat.

A number of pains, cramps and spasmodic disorders are caused by insufficient or uneven blood flow to the outer skin.

In many cases, relief, improvement or even a cure can be achieved through the consistent application of heat. Treatment with infrared rays, hot _water bottles, heating pads, hot packs and compresses always involves considerable effort and therefore cannot always be carried out without difficulty.

It is also known that transdermally absorbable active ingredients, especially medicinal plant oils, are therapeutically effective especially when they are allowed to act for a sufficiently long time and have the opportunity to penetrate the skin. People have long been looking for ways to increase the effectiveness of transdermally absorbable active ingredients.

EP-A 0 163 045 describes means for thermal insulation and for storing and distributing heat, in particular body heat, on surfaces

the outer skin, which consists of a laminate, a foam layer, a flexible, heat-conducting metal layer and another foam layer. These materials have already proven themselves as warming plasters, pillows, mats, etc.*

The invention has set itself the task of combining this principle of therapy with heat with the principle of applying transdermally absorbable active substances, in particular medicinal plant oils, in order to increase and optimize the therapeutic effectiveness.

This task can be solved surprisingly well and simply by means for the application of transdermally absorbable active substances, consisting of at least one replaceable carrier impregnated with the transdermally absorbable active substances

(1) and a holder (2) for the carrier, consisting of a laminate of

a) a 1 to 5 mm thick, closed-cell polyethylene foam layer (3),

(b) a flexible, thermally conductive metal foil (4),

c) a 1 to 4 mm thick, optionally coloured, closed-cell polyethylene foam

layer (5) and

d) a 1 to 4 mm thick, optionally dimpled, closed-cell polyethylene foam layer (6), from which at least one preferred

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a serrated piece (7) is punched out, whereby the piece (7) is the same size or slightly larger in area than the carrier (1)/

or

ä) a 2 to 5 m² thick, closed-pore polyethylene shell material layer (3),

(b) a flexible/thermally conductive metal foil (4),

c) a 2 to 5 strong, possibly studded

closed-pore polyethylene foam layer (6), from which at least one preferred

a serrated piece (7) is punched out, the piece (7) being the same size or slightly larger in area than the carrier (1)

or

a) a 2 to 6 mm thick, closed-cell polyethylene foam layer (3), optionally coloured, and

b) a 2 to 5 mm thick, optionally dimpled, closed-cell polyethylene foam layer (6), from which at least one preferably serrated piece (7) is punched out, the absorbent carrier (1) then being coated on one side with

which is firmly connected to the flexible, thermally conductive metal foil (4).

These agents preferably have a foam layer for easier attachment to the body.

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(3) a fabric layer (8) which preferably consists of boron nitrate. This fabric layer allows the inventive agent to be attached to the body using skin-friendly, self-adhesive plasters or elastic bandages with Velcro fasteners.

The agents according to the invention can then be produced in the form of plasters, but also headbands or ^pillows , whereby headbands or pillows usually have several punched-out pieces (7) and carriers (1) impregnated with transdermally absorbable active substances, which are inserted therein in an interchangeable manner.

As a carrier (1), nonwovens and in particular all skin-compatible random fiber nonwovens that have sufficient rigidity and can be impregnated with the transdermally absorbable active ingredients can be used. In principle, however, other sufficiently rigid, skin-compatible, absorbent carriers that are resistant to transdermally absorbable active ingredients, such as open-pore foams, fabrics, etc., can also be used. The shape of these impregnated carriers can be chosen as desired, for example square, rectangular or polygonal. The circular shape is particularly simple and preferred. These carriers impregnated with transdermally absorbable active ingredients can either be freshly prepared by the user themselves, or they can be supplied sealed by the manufacturer - similar to refreshing wipes.

The punched pieces (7) are the same size or slightly larger than the carrier

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(1) and preferably serrated. This design ensures that the carrier is held securely in the cutout and that small air pockets are formed on the edge of the carrier in which vapors from the transdermally absorbable active ingredients can collect.

The closed-cell polyethylene foam layers (3), (5) and (6) can be in the above-mentioned

IC frames can vary in thickness between 1 and 5 or 1 and 6 mm, but the overall laminate should have a thickness between 5 and 12, preferably 6 to 10 mm. Thinner laminates are difficult to produce and do not ensure sufficient heat storage. Thicker laminates become too stiff and unwieldy and add too much bulk.

Aluminium foil is used in particular as a flexible, thermally conductive metal foil, which preferably has thicknesses between 20 and 50 μιλ.

In a simpler and technically preferred embodiment, the foam layer (5) is omitted, so that the carrier (1) comes into direct contact with the metal foil (4). This can lead to an even faster and stronger heating of the carrier (1) and thus a faster and stronger onset of effect.

Finally, it is also possible to completely omit the metal foil (4) in the laminate of the holder (2) / if the absorbent carrier (1) is firmly connected on one side to this flexible/ heat-conductive metal foil (4) § . In this embodiment

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the two remaining foam layers (3) and (6) are preferably colored in different colors. Furthermore, in this embodiment, layer (3) in particular is chosen to be thicker and/ 5 or made of a foam with larger pores, which has a higher thermal insulation capacity.

The astonishingly good effectiveness of the agents according to the invention is due to the following mechanism of action: the overall laminate of the holder

(3) leads to a good storage and distribution of body heat, as with the agents according to EP-A 0 163 045. It can be seen that the return of heat to the body is particularly strong in the punched-out piece (7). However, it is precisely at this point that the carrier (1) impregnated with the transdermally absorbable active ingredients is located, so that the transdermally absorbable active ingredients contained therein

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substances are heated to a particularly high temperature. This leads to an increased vapor pressure of the transdermally absorbable active substances and an increased effectiveness in the area of the punched-out pieces (7). In | the air chambers on the edge of the carrier |

collect these vapors of the transdermally absorbable active ingredients so that they can develop their effectiveness over a longer period of time. The metal foil (4) simultaneously acts as a vapor barrier and prevents the vapors from escaping prematurely through the foam. |

Because the foam layer (6) adjacent to the skin is preferably napped, a certain amount of ventilation takes place and undesirable sweating is suppressed. This napping also allows a certain amount of

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transdermally absorbable active ingredient vapors are effective beyond the area of the punched-out area. The nubs therefore preferably consist of a square pattern of embossed grooves at a distance of 1 to 3 mm. The grooves are approx. 0.5 to 2 mm deep. Instead of the nubs, it is also possible to laminate the layer (6) with a fabric layer.

Measurements of the skin temperature under the influence of the agents according to the invention have shown that the greatest heating occurs at the edge of the carrier (1), _namely in the ventilation chambers. This can only be explained by the fact that at these points there is the least thermal insulation, so that the heat collected all around by the holder (2) can be returned to the skin relatively undisturbed and at these points the vapors of the transdermally absorbable active ingredients can act on the skin in relatively high concentrations.

When producing the holder (2), it would in principle be possible to produce the polyethylene foam layers (5) and (6) or (4) and (6) or even (3) and (6) from one piece, and then punch out the piece (7) from this piece in such a way that up to 4 mm of foam layer can remain between the carrier (1) and the metal foil (4). However, this is much more difficult in terms of production technology than laminating the two layers together from partial layers, as stated above. This has the further advantage that the foam layers (5) or (3) can be colored so that the punched out piece (7) clearly blends in visually.

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I eye. This facilitates the insertion of the

1 carrier (1) into the cutout. Instead of the piece

f (7) it is of course also possible to punch

This can be hot stamped, although sharp 5 points are rarely available. For better fastening I of the carrier (1) to the holder (2),

I also an adhesive glue or a piece of double-sided

adhesive film can be used.

* 10 The carriers (1) are usually removed after application

&iacgr; discarded, while the holder (2) is often

f can be used. It can also be used at tempera-

I doors washed up to 30 ⁰ C and therefore hygienic

I. As in the heat transdermal re-

I 15 sorbable active substances are used in particular in liquid

I ities such as oils, but also pastes and powders in

I question, provided they have a sufficiently high steam

j pressure. In particular, medicinal plants

- oils are suitable. The preferred medicinal plant oils are

'' 20 essential oils such as camphor oil, green oil, lavender oil,

Peppermint oil, rosemary oil and turpentine oil as well as

' Mixtures of these are used. These oils come

together with the long-lasting warming therapeutic

* table for use in muscle and joint pain, 25 lumbago, sciatica, disc problems and

rheumatic complaints. They can also be used for the prevention and aftercare of sports injuries, strains and bruises. In all of these cases, tissue metabolism is increased and blood circulation is improved. The agents according to the invention therefore represent an excellent applicator, particularly for medicinal plant oils and their vapors, whereby the effectiveness is intensified and prolonged.

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The attached figures show preferred embodiments of the inventive agent for the application of transdermally absorbable active substances. Fig. 1 shows a plan view of an agent in the form of a plaster. Fig. 2 shows a section through this agent. Figs _{. 3} and 4 show a section through simplified embodiments.

In the figures,

(1) a carrier impregnated with the transdermally absorbable active ingredients

(2) the entire bracket

(3) a closed-cell polyethylene foam layer

(4) a flexible, thermally conductive metal foil

(5) an optionally coloured, closed-cell polyethylene foam layer

(6) a possibly dimpled or woven

laminated, closed-cell polyethylene foam layer

(7) a jagged punched piece

(8) a fabric layer made of Borsched nylon.
25

In this preferred embodiment according to Fig. 2 the thickness of the polyethylene foam layer is

(3) approx. 2 mm, the polyethylene foam layer (5) approx. 3 mm and the polyethylene foam layer

(6) originally also 2 mm, in the dimpled state 1 to 1.8 mm. Consequently, the depth of the cut-out (7) is also approx. 1.8 mm. In the embodiments according to Fig. 3 and 4, the foam layers are usually somewhat thicker.

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Not shown are the replaceable self-adhesive/skin-compatible plaster or the elastic bandage with Velcro fastener for attaching the agent according to the invention to the skin. Due to the fabric layer (8), _which preferably consists of borshad nylon, both the self-adhesive plasters and Velcro fasteners adhere sufficiently firmly, but can be removed again without damaging the holder (2), so that this holder (2) can be reused frequently.

The punched-out piece (7) is serrated according to Fig. 1 in such a way that sawtooth-shaped ventilation chambers are created. With the inserted carrier, the image of a petal or the halo of a sun is created. In principle, however, straight serrations or even wavy-line and thus rounded serrations can also be used, provided they are able to adequately hold the carrier (1) soaked with the transdermally absorbable active ingredients.

To produce a corresponding headband, an elongated holder of 10 to 20 cm length and 2 to 3 cm width is produced, in which several pieces (7) are punched out next to each other and correspondingly smaller straps (1) can be inserted. For the production of pillows, however, the dimensions are chosen to be larger and several pieces (7) are also punched out, into which correspondingly large straps (1) can then be inserted.

Claims (3)

protection claims; Means for the application of transdermally absorbable active substances, characterized in that they consist of at least one replaceable carrier (1) impregnated with the transdermally absorbable active substances and a holder (2) for the carrier, the carrier consisting either of a laminate of a) a 1 to 5 mm thick, closed-cell polyethylene foam layer (3), b) a flexible, thermally conductive metal foil (4), c) a 1 to 4 mm thick, closed-cell polyethylene foam layer (5) and d) a 1 to 4 mm thick, optionally dimpled, closed-pore polyethylene foam layer (6), from which at least one preferably serrated piece (7) is punched out, the piece (7) being the same size or slightly larger in area than the carrier (1), or a) a 2 to 5 mm thick, closed-cell polyethylene foam layer (3), b) a flexible, thermally conductive metal foil (4), &sgr;) a 2 to 5 mm thick, optionally dimpled, closed-pore polyethylene foam layer (6) from which at least one preferably serrated piece (7) is punched out, the piece (7) being the same size or slightly larger in area than the carrier (1) or a) a 2 to 6 mm thick, closed-cell polyethylene foam layer (3) , and b) a 2 to 5 mm thick, optionally dimpled, closed-pore polyethylene foam layer (6), from which at least one preferably serrated piece (7) is punched out, whereby the absorbent carrier (1) is then firmly connected on one side to the flexible, heat-conductive metal foil (4). 2. Means according to claim 1, characterized in that a fabric layer (8) is laminated onto the foam layer (3). 3. Agent according to claim 1 or 2, characterized in that it has the form of a plaster, headband or cushion.