DE844297C - Process for the degradation of inositol phosphoric acid salts - Google Patents
Process for the degradation of inositol phosphoric acid saltsInfo
- Publication number
- DE844297C DE844297C DEF5237A DEF0005237A DE844297C DE 844297 C DE844297 C DE 844297C DE F5237 A DEF5237 A DE F5237A DE F0005237 A DEF0005237 A DE F0005237A DE 844297 C DE844297 C DE 844297C
- Authority
- DE
- Germany
- Prior art keywords
- degradation
- phosphoric acid
- acid salts
- inositol
- inositol phosphoric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title claims description 8
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 title claims description 6
- 229960000367 inositol Drugs 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 6
- 230000015556 catabolic process Effects 0.000 title claims description 5
- 238000006731 degradation reaction Methods 0.000 title claims description 5
- -1 inositol phosphoric acid salts Chemical class 0.000 title claims description 5
- 150000003839 salts Chemical class 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Diphosphoinositol tetrakisphosphate Chemical compound OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- YDHWWBZFRZWVHO-UHFFFAOYSA-H [oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O YDHWWBZFRZWVHO-UHFFFAOYSA-H 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 108010011619 6-Phytase Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 description 1
- YDHWWBZFRZWVHO-UHFFFAOYSA-N [hydroxy(phosphonooxy)phosphoryl] phosphono hydrogen phosphate Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O YDHWWBZFRZWVHO-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001768 cations Chemical group 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940085127 phytase Drugs 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zum Abbau von inositphosphorsauren Salzen Ein Verfahren zum Abbau von Tetracalciuminosittetraphosphatwurde von L u e r s und S i 1 -b e r e i s e n beschrieben, und zwar wurde Monocalciuminositmonophosphat durch Einwirkung von Phytase auf Phytin und dabei nur in sehr geringen Mengen erhalten. Die Abtrennung des Inositmonophosphates ist hei dieser Darstellungsmethode sehr umständlich, weil eine Reihe von schwer abtrennbaren Nebenprodukten dabei entsteht.Process for the degradation of inositol phosphoric acid salts A process for the degradation of tetracalcium inosite tetraphosphate was used by Lu e r s and S i 1 -b e r e i s e n, namely Monocalciuminositmonophosphat was by action from phytase to phytin and only obtained in very small quantities. The separation of inositol monophosphate is very cumbersome with this method of representation, because a number of by-products that are difficult to separate are created.
Gemäß der vorliegenden Erfindung wird in einfacher und quantitativer Weise ein ähnlicher Abbau durch Anwendung von lonenaustauschern durchgeführt. Als solche bezeichnet man bekanntlich bestimmte Stoffe, z. B. Permutit, welche die Eigenschaft haben, die Kationen durch Wasserstoff zu ersetzen. Im vorliegenden Fall hat sich darüber hinaus gezeigt, daf..i diese Ionenaustauscher auch eine Hydrolyse herbeiführen. Schickt man z. B. Tetracalciuminosittetraphosphat durch einen solchen Ionenaustauscher, so erhält man eine Verbindung, welche an Calcium und Phosphorsäure ärmer ist; dadurch wird die Wasserlöslichkeit des Endproduktes erzielt. Dies ist natürlich für die therapeutische Anwendung von der größten Bedeutung.According to the present invention it becomes simpler and more quantitative A similar degradation was carried out by using ion exchangers. as such are known to be certain substances such. B. Permutit, which is the property have to replace the cations with hydrogen. In the present case also shown that these ion exchangers also bring about hydrolysis. If you send z. B. Tetracalciuminosittetraphosphat by such an ion exchanger, in this way a compound is obtained which is poorer in calcium and phosphoric acid; through this the water solubility of the end product is achieved. This is of course for that therapeutic application of the greatest importance.
Als weitere inositphosphorsaure Salze seien beispielsweise genannt: Dodekanatriuminosithexaphosphat, das entsprechende Kaliumsalz. Alkali-und Erdalkalisalze sowie gemischte Alkali-Erdalkali-Salze der Inosithexa- und Inosittetraphosphorsäure, endlich Phytin.Examples of further inositol phosphoric acid salts include: Dodecasodium inositol hexaphosphate, the corresponding potassium salt. Alkali and alkaline earth salts and mixed alkali-alkaline earth salts of inositol hexa- and inositol tetraphosphoric acid, finally phytin.
Beispiel Sog eines 7oo/oigen Tetracalciuminosittetraphosphates werden mit Zoo ccm n/2-H Cl 2 Stunden geschüttelt, dann filtriert und langsam durch eine 14 : 4 cm messende lonenaustauschersäule (bekannt unter der Handelsbezeichnung »Wofatit F« geschickt.Example, suction of a 700% tetracalcium inosite tetraphosphate with zoo ccm n / 2-H Cl 2 hours shaken, then filtered and slowly through an ion exchange column measuring 14: 4 cm (known under the trade name "Wofatit F" sent.
Es wird mit n/lo-H Cl nachgewaschen. Das Filtrat, vereinigt mit dem
Waschwasser, wird auf ioo ccm eingeengt, filtriert oder mit Tierkohle behandelt
und filtriert und schließlich weiter bis auf ,5o ccm eingeengt. Nach dem Erkalten
wird die etitstanderie Paste mit der doppelten :Menge goo/oigen Äthanols versetzt,
wobei sich eine weiße Substanz körnig oder in Flocken abscheidet. Diese wird al>-genutscht,
in kaltem Wasser gelöst und entweder durch Erhitzen oder durch Alkoholzusatz wie
oben ausgefällt. Nach dreimaliger Wiederholung von Lösen und Fällen ist die Substanz
rein. Man reibt sie nun mit absolutem Äthanol oder Methanol so lange durch, bis
sie vollends körnig geworden ist. Dieses sandige Pulver wird nach dem Abnutschen
im Vakuum getrocknet.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF5237A DE844297C (en) | 1950-12-14 | 1950-12-14 | Process for the degradation of inositol phosphoric acid salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF5237A DE844297C (en) | 1950-12-14 | 1950-12-14 | Process for the degradation of inositol phosphoric acid salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE844297C true DE844297C (en) | 1952-09-15 |
Family
ID=7084484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF5237A Expired DE844297C (en) | 1950-12-14 | 1950-12-14 | Process for the degradation of inositol phosphoric acid salts |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE844297C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1299497B (en) * | 1966-04-15 | 1969-07-17 | Bbc Brown Boveri & Cie | Arrangement for inductive continuous longitudinal seam welding of metal pipes |
-
1950
- 1950-12-14 DE DEF5237A patent/DE844297C/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1299497B (en) * | 1966-04-15 | 1969-07-17 | Bbc Brown Boveri & Cie | Arrangement for inductive continuous longitudinal seam welding of metal pipes |
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