DE832320C - Process for the production of a sage extract rich in tannin - Google Patents
Process for the production of a sage extract rich in tanninInfo
- Publication number
- DE832320C DE832320C DEP2736A DEP0002736A DE832320C DE 832320 C DE832320 C DE 832320C DE P2736 A DEP2736 A DE P2736A DE P0002736 A DEP0002736 A DE P0002736A DE 832320 C DE832320 C DE 832320C
- Authority
- DE
- Germany
- Prior art keywords
- tannin
- production
- extract
- extract rich
- sage extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920001864 tannin Polymers 0.000 title claims description 10
- 239000001648 tannin Substances 0.000 title claims description 10
- 235000018553 tannin Nutrition 0.000 title claims description 10
- 235000020752 sage extract Nutrition 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 4
- 229940112950 sage extract Drugs 0.000 title claims description 4
- 239000000284 extract Substances 0.000 claims description 7
- 229930002875 chlorophyll Natural products 0.000 claims description 5
- 235000019804 chlorophyll Nutrition 0.000 claims description 5
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229920000473 Phlobaphene Polymers 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 241000972773 Aulopiformes Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Description
Verfahren zur Herstellung eines gerbstoffreichen Salbeiauszuges l)ie wirksamen Inhaltsstoffe des Sall>ei sind vor allem das ätherische Öl und die Gerbstoffe. Als Lösungsmittel, welches ätherisches öl und Gerbstoffe gleichzeitig löst, eignet sich am besten wäB-riger Alkohol. Wird nun zur Herstellung einer die Wirkstoffe enthaltenden Lösung ein wäßrig alkoholischer Sal4>eiauszug eingeengt, so fallen zunächst bei größerer Verdünnung Chlorophyll- und Harzbestandteile aus, von denen üblicherweise zwecks Gewinnung einer klaren Lösung abfiltriert wird.Process for the production of a sage extract rich in tannin l) ie The most effective ingredients of the salmon egg are the essential oil and the Tannins. As a solvent, which essential oil and tannins at the same time dissolves, aqueous alcohol is best. Will now be used to manufacture a die A solution containing active ingredients is concentrated in an aqueous alcoholic saline extract, in this way, chlorophyll and resin components initially precipitate with greater dilution, which is usually filtered off to obtain a clear solution.
Wird die Lösung weiter eingeengt, bis das Extraktgewicht gleich dem Drogengewicht ist, so fällt ein Teil der Gerbstoffe unter Phlobaphenhildung unlöslich aus und wird somit der therapeutischen Wirkung entzogen. Vermutlich ist darauf die Tatsache zurückzuführen, daß der Gerbstoffgehalt von Salheipräparaten des Handels stark schwankt, so daß mitunter diese ül>erhaupt keinen Gerbstoff mehr enthalten.The solution is further concentrated until the extract weight equals that Drug weight, some of the tannins are insoluble with phlobaphene formation and is thus withdrawn from the therapeutic effect. Probably the one on it The fact that the tannin content of salhei preparations on the market fluctuates strongly, so that sometimes these oils no longer contain any tannin at all.
Es wurde nun ül>erraschender'vei se gefunden. daß die Umwandlung der Gerbstoffe in Phlobaphene unterbleibt, wenn die zu Beginn des Einengens sich abscheidenden Chlorophyll- und Harzbestandteile nicht abfiltriert, sondern bis zur Beendigung der Konzentrierung in der Lösung belassen werden. Wird die Einengung nach diesem Verfahren vorgenommen und erst nach Beendigung filtriert, so erhält man ein klares Filtrat, das alle Gerbstoffe in wirksamer Form enthält. Eine nachträgliche Umwandlung der Genbstoffe, die zu Ausscheidungen führt, tritt nicht ein. Der gerbstofffreie Rückstand besteht nur aus Chlorophyll- und Harzbestandteilen. It has now been found, more surprisingly. that the conversion the tannins in Phlobaphene cease to exist when the beginning of the constriction separating chlorophyll and resin components are not filtered off, but up to Be left in the solution upon completion of the concentration. Will the narrowing made according to this process and filtered only after completion, so obtained a clear filtrate containing all the tannins in an effective form. A subsequent one Conversion of the genetic material, which leads to excretions, does not occur. The tannin-free Residue consists only of chlorophyll and resin components.
Beispiel I kg gepulverte und gelagerte Salheiblätter der den mit IO l 70% igem Alkohol bei Raumtemperatur mazeriert. Der abgetrennte Auszug wird im Va- kuum, z. B. dem der Wasserstrahlpumpe, auf das Drogengewicht eingeengt. Die bei der Destillation ausfallenden Chlorophyll- und Harzbestandteile werden dem Auszug bis zum Ende der Destillation belassen und können dann durch Filtrieren leicht entfernt werden. Nach 24stündigem Stehen wird der Drogenauszug mit Alkohol auf das It/2fache des Drogengewichts gebracht. Neben Äthylalkohol hat sich als besonders vorteilhaft mehrwertiger Alkohol, z. 13. Äthylenglykol bewährt, dessen süßer Geschmack den bitteren des Salbeiauszuges überdeckt. Dieser Salheiextrakt ist mit Wasser in jedem Verhältnis klar mischl)ar. Example I kg of powdered and stored sage leaves of the with IO l 70% alcohol macerated at room temperature. The detached extract is in the va- kuum, e.g. B. that of the water jet pump, on the drug weight constricted. The chlorophyll and resin components precipitated during the distillation are left with the extract until the end of the distillation and can then be filtered easily removed. After standing for 24 hours, the drug extract is made with alcohol brought to It / 2 times the drug weight. Besides ethyl alcohol has proven to be special advantageously polyhydric alcohol, e.g. 13. Ethylene glycol proven, its sweet taste covers the bitter of the sage extract. This salhey extract is in Clearly mixed in every relationship.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP2736A DE832320C (en) | 1948-10-02 | 1948-10-02 | Process for the production of a sage extract rich in tannin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP2736A DE832320C (en) | 1948-10-02 | 1948-10-02 | Process for the production of a sage extract rich in tannin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE832320C true DE832320C (en) | 1952-02-25 |
Family
ID=7358224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEP2736A Expired DE832320C (en) | 1948-10-02 | 1948-10-02 | Process for the production of a sage extract rich in tannin |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE832320C (en) |
-
1948
- 1948-10-02 DE DEP2736A patent/DE832320C/en not_active Expired
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