DE816390C - Process for the production of dry preparations with viable bacteria - Google Patents

Process for the production of dry preparations with viable bacteria

Info

Publication number
DE816390C
DE816390C DEL1426A DEL0001426A DE816390C DE 816390 C DE816390 C DE 816390C DE L1426 A DEL1426 A DE L1426A DE L0001426 A DEL0001426 A DE L0001426A DE 816390 C DE816390 C DE 816390C
Authority
DE
Germany
Prior art keywords
production
bacteria
viable bacteria
dry preparations
dry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEL1426A
Other languages
German (de)
Inventor
Wolfgang Dr Laves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LECINWERK DR ERNST LAVES
Original Assignee
LECINWERK DR ERNST LAVES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LECINWERK DR ERNST LAVES filed Critical LECINWERK DR ERNST LAVES
Priority to DEL1426A priority Critical patent/DE816390C/en
Application granted granted Critical
Publication of DE816390C publication Critical patent/DE816390C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

Verfahren zur Herstellung von Trockenpräparaten mit lebensfähigen Bakterien Für 1harnakologische Zwecke hat sich des öfteren die Notwendigkeit ergeben, lel>ende Bakterien, WIilehsãure-, Joghurt-, Coli-, Kaltblütertuberkulose-I)azillen u. a. Bakterien einem lebenden Körper zuzuführen.Process for the preparation of dry preparations with viable bacteria For 1harnacological purposes the need has often arisen lel> ende bacteria, wilehic acid, yoghurt, coli, cold-blooded tuberculosis (I) acilli i.a. Delivering bacteria to a living body.

Dauerpräparate dieser Art wurden entweder in flüssigen Lösungen (Nährstoff- oder physiologischen Kochsalzlösungen) oder aber in Emulsionen auf Fettbasis oder in Form gelatinierender Mittel, die in darmlöslichen Kapseln zugeführt werden, gegeben. Versuche, in einer trockenen Substanz lebende Bakterien möglichst lange am Pelzen und wirksam zu erhalten. sind mit Milchzucker oder anderen indifferenten Mitteln bekannt, aber die Lebensdau.r in diesel Trockensubstanzen ist bei empfindlichen Bakterien sogar nur auf wenige Tage, falls sie keine Sporen zu bilden vermögen, beschränkt. Long-term preparations of this type were either in liquid solutions (nutrient or physiological saline solutions) or in emulsions based on fat or in the form of gelatinizing agents that are supplied in enteric capsules. Try to keep bacteria living in a dry substance on the fur for as long as possible and effective to maintain. are with milk sugar or other indifferent means known, but the lifespan in diesel dry substances is for sensitive ones Bacteria only for a few days if they are unable to form spores, limited.

Gegenstand des Verfahrens gemäß der Erfindung ist, lebende Bakterien solchem indifferenten Medium zuzuführen, welches große Hohlräume enthält und nicht aus einer organischen Substanz, sondern aus einer anorganischen besteht, die leicht zu sterilisieren ist. The subject of the method according to the invention is living bacteria to supply such an indifferent medium which contains large cavities and does not consists of an organic substance but of an inorganic one that is easily to be sterilized.

Die Diatomeenerde enthält unzählige kleine Kieselsäureschalen von früheren Meeresalgen. Diese wird ausgeglüht und nach Erkalten mit einer Aufschwemmung der gewünschten Bakteriensorte verrieben. Die Bakterien wandern in die kleinsten Hohlraume. Das so erhaltene Pulver kann ohne weiteres auf Fertigpräparate v erarbeitet werden. Da auf diese Weise den Bakterien auch eine gewisse Menge Nährboden mitgegeben werden kann, halten sich dieselben längere Zeit als in Trockensubstanz und können bei ihrer therapeutischen Anwendung ihr Wachstum im Darm auch dann noch entfalten, wenn dies für sie, als Trockensubstanz mit gleichem Alter gereicht, nicht mehr möglich ist. The diatomaceous earth contains innumerable small silica shells of previous seaweed. This is annealed and after cooling with a suspension the desired bacterial species rubbed in. The bacteria migrate into the smallest Cavities. The powder obtained in this way can easily be processed into finished preparations will. Because on this Tell the bacteria a certain amount too Can be given nutrient medium, the same hold longer than in dry matter and with their therapeutic application they can still grow in the intestine unfold if this is not enough for them as dry matter with the same age more is possible.

Beispiel 25 g Diatomeenerde werden ausgeglüht und nach Abkühlung mit einer Aufschwemmung von 5 ccm Tuberkulosebakterien gemischt, in der Reibeschale stark verrieben und der weiteren Verarbeitung (Oblaten, Tabletten usw.) übergeben. Example 25 g of diatomaceous earth are calcined and after cooling mixed with a suspension of 5 cc of tuberculosis bacteria in the grater heavily rubbed and handed over for further processing (wafers, tablets, etc.).

Claims (1)

PATENTANSPR-UCH: Verfahren zur Herstellung von haltbaren, äußerlich trockenen Bakterienpräparaten dadurch gekennzeichnet, daß Diatomeenerde zur Aufnahme von konzentrierter Rakterienaufschwemmung verwandt und zu einem trockenen Pulver, gegebenenfalls unter Verwendung geeigneter Nährlösung, verarbeitet wird. PATENT CLAIM: Process for the production of durable, externally dry bacterial preparations characterized in that diatomaceous earth for uptake related to concentrated bacteria suspension and to a dry powder, if necessary using a suitable nutrient solution, is processed.
DEL1426A 1950-03-17 1950-03-17 Process for the production of dry preparations with viable bacteria Expired DE816390C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEL1426A DE816390C (en) 1950-03-17 1950-03-17 Process for the production of dry preparations with viable bacteria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEL1426A DE816390C (en) 1950-03-17 1950-03-17 Process for the production of dry preparations with viable bacteria

Publications (1)

Publication Number Publication Date
DE816390C true DE816390C (en) 1951-10-11

Family

ID=7255388

Family Applications (1)

Application Number Title Priority Date Filing Date
DEL1426A Expired DE816390C (en) 1950-03-17 1950-03-17 Process for the production of dry preparations with viable bacteria

Country Status (1)

Country Link
DE (1) DE816390C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614348A1 (en) * 1976-04-01 1977-10-06 Hefe Ind Versuchsanst POWDERED, FREE-FLOWING FRESH BAKING YEAST PREPARATION AND PROCESS FOR ITS MANUFACTURING

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614348A1 (en) * 1976-04-01 1977-10-06 Hefe Ind Versuchsanst POWDERED, FREE-FLOWING FRESH BAKING YEAST PREPARATION AND PROCESS FOR ITS MANUFACTURING

Similar Documents

Publication Publication Date Title
DE60005104T2 (en) DIET ADDITIVE FROM FERMENTED MILK PRODUCTS FOR PREVENTING ÖSTEOPOROSIS
DE816390C (en) Process for the production of dry preparations with viable bacteria
DE288375C (en)
DE1492979A1 (en) Process for the vitaminization of protein-containing food substances
DE923158C (en) Process for the production of a non-hygroscopic dietetic nutritional and strengthening agent
DE831799C (en) Process for refining raw cocoa and raw materials made from it
DE456284C (en) Process for the production of easily digestible feed and food with a pleasant smell and taste from inferior materials
DE959219C (en) Process for the preparation of mucus ointments
DE964089C (en) Process for the biological production of vitamin B.
DE490184C (en) Process for the production of stable yeast preparations
DE679659C (en) Process for improving dental and oral care products
DE909985C (en) Growth-promoting additive to nutritional solutions in the biological production of penicillin
DE810689C (en) Method of salting cheese
DE536211C (en) Process for the production of therapeutically effective garment products
DE700475C (en) Process for the production of cheese-like preparations
DE856285C (en) Process for the production of technically and therapeutically effective bacterial preparations
DE298133C (en)
Kihara Desoxycholsäure aus Fuchsgalle (Vulpes)
DE1075417B (en) Process for the production of a pathogen-free dry powder based on milk which is suitable for rearing calves
DE725024C (en) Process for the production of baker's yeast with delayed fermentation effect and long shelf life
DE745442C (en) Process for the production of beverages containing vitamins, especially beers
DE862740C (en) Process for the production of a malt-milk preparation
DE605941C (en) Process for the production of a durable sauerkohlpreparates suitable for cosmetic, cleaning and pleasure purposes
DE937248C (en) Process for the production of nutritional solutions for breeding micromycetes
CH171701A (en) Process for the production of a long-life product containing the Bacillus bulgaricus of yoghurt, which can be used as a substitute for fresh yoghurt milk.