DE706810C - Process for the preparation of a durable dry vaccine for avian diphtheria - Google Patents

Process for the preparation of a durable dry vaccine for avian diphtheria

Info

Publication number
DE706810C
DE706810C DEI66183D DEI0066183D DE706810C DE 706810 C DE706810 C DE 706810C DE I66183 D DEI66183 D DE I66183D DE I0066183 D DEI0066183 D DE I0066183D DE 706810 C DE706810 C DE 706810C
Authority
DE
Germany
Prior art keywords
preparation
diphtheria
dry vaccine
avian
durable dry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI66183D
Other languages
German (de)
Inventor
Dr Carl Ludwig Lautenschlaeger
Dr Gottfried Pyl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI66183D priority Critical patent/DE706810C/en
Application granted granted Critical
Publication of DE706810C publication Critical patent/DE706810C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/187—Hog cholera virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Description

Verfahren zur Herstellung eines haltbaren Trockenimpfstoffes für Geflügeldiphtherie Es fehlt nicht an Versuchen, das gegen Erwärmung empfindliche Virus der Geflügeldiphtherie zu Impfstoffzwecken zu konservieren. Man hat seine Haltbarkeit in flüssiger Form z. B. durch Zusatz von Glycerin, durch Vermischen mit Fetten oder Agar-Agar verbessert. Trotzdem lassen die nach obigen Verfahren darstellbaren Präparate bezüglich ihrer Haltbarkeit noch zu wünschen übrig.Process for the preparation of a durable dry vaccine for avian diphtheria There has been no lack of attempts to find the warming-sensitive avian diphtheria virus to preserve for vaccine purposes. One has its shelf life in liquid form z. B. improved by adding glycerol, by mixing with fats or agar-agar. Nonetheless, the preparations that can be prepared by the above process leave their Durability still to be desired.

Es wurde nun gefunden, daß man die Haltbarkeit eines Geflügeldiphtherieimpfstoffes dadurch besonders erhöhen kann, daß man dem das Virus enthaltenden Extrakt vor dem Trocknen zusätzliches Eiweiß beimischt. Hierbei kann es zwecksmäßig sein, den Extrakt in geeigneter Weise zu neutralisieren bzw. das Virus aus dem Gewebe gleich bei neutraler Reaktion zu extrahieren. Die auf schonende Weise getrockneten Präparate werden zweckmäßig im Vakuum aufbewahrt. Derartige Impfstoffe sind bei Zimmertemperatur jahrelang haltbar und überstehen sogar eine mehrwöchige Erwärmung auf über 500. It has now been found that one can improve the shelf life of an avian diphtheria vaccine can thereby particularly increase that the extract containing the virus before Drying additional egg whites are added. Here it can be useful to use the extract to neutralize in a suitable manner or the virus from the tissue equal to neutral Extract reaction. The gently dried preparations are useful stored in a vacuum. Such vaccines can be stored for years at room temperature and even survive several weeks of warming to over 500.

Beispiele 1. Zehn Tauben werden auf der Brust mit einem geeigneten Geflügeldiphthlerievirus geimpft und auf dem Höhepunkt der Erkrankung getötet. Die abpräparierte Brusthaut wird darauf mit 650 dem physiologischer Kochsalzlösung fein gemahlen und nach dem Entfernen der bindegewebigen Anteile mit leder Lösung von 50 g Albumin in 300 ccm Wasser vermengt. Die Mischung wird, gegebenen falls in Ampullen, in gefrorenem Zzstand im Vakuum über Schwefelsäure getrocknet und die Ampullen im Vakuum abgeschmolzen. Examples 1. Ten pigeons are on the chest with a suitable Avian diphthler virus vaccinated and killed at the height of the disease. the The prepared breast skin is then fine-tuned with the physiological saline solution ground and after removing the connective tissue with leather solution of 50 g of albumin mixed in 300 cc of water. The mixture is given if in ampoules, dried in a frozen Zzstand in vacuo over sulfuric acid and the Ampoules melted in a vacuum.

2. Die Taubenhaut wird arie im Beispiel r verarbeitet, doch wird der mit Eiweiß versetzte Extrakt vor dem Trocknen mit einem geeigneten Puffer auf neutrale bis schwach alkalische Reaktion eingestellt. 2. The pigeon skin is processed aria in the example r, but is the protein-enriched extract with a suitable buffer before drying neutral to slightly alkaline reaction set.

Claims (2)

PATENTANSPRÜCHE: 1. Verfahren zur Herstellung eines haltbaren Trockenimpfstoffes für Geflügeldiphtherie, dadurch gekennzeichnet, daß man Geflügeldiphtberievirus vor dem Eintrocknen mit Eiweiß versetzt. PATENT CLAIMS: 1. Process for the production of a durable dry vaccine for poultry diphtheria, characterized in that one poultry diphtberia virus Egg white added before drying. 2. Verfahren nach Anspruch I, dadurch gekennzeichnet, daß man die Extrakte auf etwa neutrale Reaktion einstellt. 2. The method according to claim I, characterized in that the Adjusts extracts to approximately neutral reaction.
DEI66183D 1939-12-22 1939-12-22 Process for the preparation of a durable dry vaccine for avian diphtheria Expired DE706810C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI66183D DE706810C (en) 1939-12-22 1939-12-22 Process for the preparation of a durable dry vaccine for avian diphtheria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI66183D DE706810C (en) 1939-12-22 1939-12-22 Process for the preparation of a durable dry vaccine for avian diphtheria

Publications (1)

Publication Number Publication Date
DE706810C true DE706810C (en) 1941-06-06

Family

ID=7196491

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI66183D Expired DE706810C (en) 1939-12-22 1939-12-22 Process for the preparation of a durable dry vaccine for avian diphtheria

Country Status (1)

Country Link
DE (1) DE706810C (en)

Similar Documents

Publication Publication Date Title
DE623821C (en) Process for the preparation of dihydromorphinones
DE706810C (en) Process for the preparation of a durable dry vaccine for avian diphtheria
Wade The sycamore lace-bug:(Corythucha ciliata, Say)
AT126297B (en) Process for the production of preparations which increase the tone of the skin blood vessels.
MATSUMORI The effect of adrenaline on the heart of the chick embryo
DE2165401C3 (en) Inactivated combination vaccine for immunizing poultry against infections of the respiratory system
Newstead et al. On a collection of pappataci flies (Phlebotomus) from India
DE518516C (en) Process for the preparation of basic bismuth salts of organic arsic acids
SU122850A1 (en) Method for making acaricidal and insecticidal liquid
DE921282C (en) Process for the production of skin creams with a blood circulation stimulating effect
DE2611979A1 (en) Antiflatulence and diarrhoea compsn. for pigs and cattle - comprising specified plants, linseed, lactic acid and cattle salt
DE2126957B2 (en) PROCESS FOR MANUFACTURING VACCINES AGAINST GAENSEHEPATITIS
DE739628C (en) Process for the production of an alkaline to neutrally reacting hair dye from poorly soluble aromatic diamines for living human hair
DE732307C (en) Process for the production of astringent tannin-protein compounds
DE862942C (en) Process for the preparation of a tissue extract and a serum stimulated by this extract
AT290200B (en) Preservatives for vegetable and animal preparations
DE2809343C2 (en) Egg-laying disease vaccine
DE474689C (en) Process for the production of water-soluble preparations and aqueous solutions of organic medicinal products which are insoluble or sparingly soluble in water
DE478167C (en) Process for obtaining permanently soluble and durable preparations with increased therapeutic effectiveness in water from proteins or their derivatives (cleavage products)
AT233167B (en) Process for the production of a vaccine for the simultaneous immunization of dogs or foxes against distemper and contagious hepatitis
DE423225C (en) Process for making bread and pastries
DE872044C (en) Process for the preparation of compounds of sex hormones
DE859517C (en) Process for the preparation of an anesthetic agent for the gastric mucosa
DE1179670B (en) Process for making vaccine against Newcastle disease
SU146915A1 (en) The method of obtaining the drug bile canned medical