DE69938241T2 - Zusammensetzungen zur behandlung von durch c. difficile toxin b verursachten durchfallerkrankungen (cdad) - Google Patents
Zusammensetzungen zur behandlung von durch c. difficile toxin b verursachten durchfallerkrankungen (cdad) Download PDFInfo
- Publication number
- DE69938241T2 DE69938241T2 DE69938241T DE69938241T DE69938241T2 DE 69938241 T2 DE69938241 T2 DE 69938241T2 DE 69938241 T DE69938241 T DE 69938241T DE 69938241 T DE69938241 T DE 69938241T DE 69938241 T2 DE69938241 T2 DE 69938241T2
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- DE
- Germany
- Prior art keywords
- toxin
- oligosaccharide
- αglc
- binding
- binding oligosaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
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- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Ceramic Engineering (AREA)
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- Oncology (AREA)
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85032 | 1998-05-28 | ||
| US09/085,032 US6013635A (en) | 1998-05-28 | 1998-05-28 | Treatment of C. difficile toxin B associated conditions |
| PCT/CA1999/000484 WO1999061031A1 (en) | 1998-05-28 | 1999-05-27 | Treatment of c. difficile toxin b associated conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69938241D1 DE69938241D1 (de) | 2008-04-10 |
| DE69938241T2 true DE69938241T2 (de) | 2008-05-29 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1089740T Pending DE1089740T1 (de) | 1998-05-28 | 1999-05-27 | Behandlung von mit c. difficile toxin b verbundenen beschwerden |
| DE69938241T Expired - Fee Related DE69938241T2 (de) | 1998-05-28 | 1999-05-27 | Zusammensetzungen zur behandlung von durch c. difficile toxin b verursachten durchfallerkrankungen (cdad) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1089740T Pending DE1089740T1 (de) | 1998-05-28 | 1999-05-27 | Behandlung von mit c. difficile toxin b verbundenen beschwerden |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6013635A (enExample) |
| EP (2) | EP1089740B8 (enExample) |
| JP (2) | JP2002516284A (enExample) |
| CN (1) | CN1298306A (enExample) |
| AT (1) | ATE387205T1 (enExample) |
| AU (1) | AU4125399A (enExample) |
| CA (1) | CA2321927A1 (enExample) |
| DE (2) | DE1089740T1 (enExample) |
| NO (1) | NO20005992L (enExample) |
| WO (1) | WO1999061031A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6034129A (en) * | 1996-06-24 | 2000-03-07 | Geltex Pharmaceuticals, Inc. | Ionic polymers as anti-infective agents |
| US6290947B1 (en) | 1997-09-19 | 2001-09-18 | Geltex Pharmaceuticals, Inc. | Ionic polymers as toxin-binding agents |
| US6013635A (en) * | 1998-05-28 | 2000-01-11 | Synsorb Biotech, Inc. | Treatment of C. difficile toxin B associated conditions |
| US6358930B1 (en) * | 1998-05-28 | 2002-03-19 | Synsorb Biotech Inc. | Treatment of C. difficile toxin B associated conditions |
| US6482402B1 (en) | 1999-05-13 | 2002-11-19 | Geltex Pharmaceuticals, Inc. | Antimicrobial compositions and methods |
| US6867194B2 (en) | 2001-08-09 | 2005-03-15 | Wayne State University | Enzyme activated nitric oxide donors |
| US7695738B2 (en) * | 2003-02-19 | 2010-04-13 | Academia Sinica | Carbohydrate encapsulated nanoparticles |
| US20050287552A1 (en) * | 2003-02-19 | 2005-12-29 | Academia Sinica, Office Of Public Affairs (Technology Transfer) | Carbohydrate encapsulated nanoparticle based affinity mass spectrometry |
| BRPI0409420A (pt) * | 2003-04-18 | 2006-04-25 | Merck Patent Gmbh | pigmentos antimicrobianos |
| GB0321996D0 (en) * | 2003-09-19 | 2003-10-22 | Novartis Nutrition Ag | Organic compounds |
| US7682631B2 (en) | 2003-10-01 | 2010-03-23 | Clemson University | Adhesin-specific nanoparticles and process for using same |
| CA2542968C (en) | 2003-10-20 | 2013-06-04 | Framework Therapeutics, L.L.C. | Zeolite molecular sieves for the removal of toxins |
| WO2006044577A1 (en) * | 2004-10-13 | 2006-04-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle |
| US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
| ES2507553T3 (es) * | 2006-08-02 | 2014-10-15 | Johannes Gutenberg-Universität Mainz | Fármaco contra intoxicaciones por LCT |
| CN101855336B (zh) * | 2007-09-14 | 2019-07-30 | 赛诺菲巴斯德生物制剂有限责任公司 | 含艰难梭菌类毒素a和b的药物组合物 |
| FR2964116B1 (fr) * | 2010-09-01 | 2017-06-02 | Biomerieux Sa | Utilisation d'un activateur de beta-glucosidase pour la detection et/ou l'identification de c.difficile |
| CN102181457B (zh) * | 2011-03-21 | 2012-07-04 | 王世霞 | 密码子优化的艰难梭菌外毒素b氨基端基因序列及其核酸疫苗 |
| GB2491117A (en) * | 2011-05-20 | 2012-11-28 | Royal Holloway & Bedford New College | Coat proteins from Clostridium and Bacillus species |
| CN104785019B (zh) * | 2015-04-09 | 2017-01-11 | 东华大学 | 异形熔喷纤维制备的高效低阻空气过滤材料 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1544908A (en) * | 1975-07-08 | 1979-04-25 | Chembiomed Ltd | Artificial oligosaccharide antigenic determinants |
| US4362720A (en) * | 1977-04-14 | 1982-12-07 | Chembiomed Ltd. | Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals |
| US5079353A (en) * | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
| US5651968A (en) * | 1991-08-23 | 1997-07-29 | Alberta Research Council | Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
| US5484773A (en) * | 1994-02-14 | 1996-01-16 | Alberta Research Council | Treatment of antibiotic associated diarrhea |
| US5733579A (en) * | 1995-04-05 | 1998-03-31 | Abbott Laboratories | Oral rehydration solution containing indigestible oligosaccharides |
| US5811409A (en) * | 1995-06-05 | 1998-09-22 | Synsorb Biotech, Inc. | Treatment of cholera |
| US5637576A (en) * | 1995-06-05 | 1997-06-10 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
| US5846943A (en) * | 1996-11-08 | 1998-12-08 | Synsorb Biotech, Inc. | Solid support matricles containing a toxin binding oligosaccharide |
| ZA983690B (en) * | 1998-04-02 | 1999-02-04 | Synsorb Biotech Inc | Solid support matrices containing a toxin binding oligosaccharide |
| US6013635A (en) * | 1998-05-28 | 2000-01-11 | Synsorb Biotech, Inc. | Treatment of C. difficile toxin B associated conditions |
-
1998
- 1998-05-28 US US09/085,032 patent/US6013635A/en not_active Expired - Fee Related
-
1999
- 1999-05-27 CN CN99805510A patent/CN1298306A/zh active Pending
- 1999-05-27 EP EP99924602A patent/EP1089740B8/en not_active Expired - Lifetime
- 1999-05-27 JP JP2000550491A patent/JP2002516284A/ja active Pending
- 1999-05-27 EP EP06009088A patent/EP1704865A3/en not_active Withdrawn
- 1999-05-27 DE DE1089740T patent/DE1089740T1/de active Pending
- 1999-05-27 AU AU41253/99A patent/AU4125399A/en not_active Abandoned
- 1999-05-27 AT AT99924602T patent/ATE387205T1/de not_active IP Right Cessation
- 1999-05-27 CA CA002321927A patent/CA2321927A1/en not_active Abandoned
- 1999-05-27 DE DE69938241T patent/DE69938241T2/de not_active Expired - Fee Related
- 1999-05-27 WO PCT/CA1999/000484 patent/WO1999061031A1/en not_active Ceased
- 1999-10-18 US US09/419,790 patent/US6107282A/en not_active Expired - Fee Related
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2000
- 2000-06-13 US US09/593,040 patent/US6465435B1/en not_active Expired - Fee Related
- 2000-11-27 NO NO20005992A patent/NO20005992L/no not_active Application Discontinuation
-
2006
- 2006-05-16 JP JP2006136969A patent/JP2006213735A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1089740T1 (de) | 2002-06-13 |
| NO20005992D0 (no) | 2000-11-27 |
| ATE387205T1 (de) | 2008-03-15 |
| EP1089740A1 (en) | 2001-04-11 |
| JP2006213735A (ja) | 2006-08-17 |
| DE69938241D1 (de) | 2008-04-10 |
| US6465435B1 (en) | 2002-10-15 |
| AU4125399A (en) | 1999-12-13 |
| CA2321927A1 (en) | 1999-12-02 |
| US6013635A (en) | 2000-01-11 |
| EP1089740B8 (en) | 2008-05-28 |
| NO20005992L (no) | 2001-01-24 |
| CN1298306A (zh) | 2001-06-06 |
| EP1089740B1 (en) | 2008-02-27 |
| EP1704865A3 (en) | 2006-12-06 |
| US6107282A (en) | 2000-08-22 |
| EP1704865A2 (en) | 2006-09-27 |
| JP2002516284A (ja) | 2002-06-04 |
| WO1999061031A1 (en) | 1999-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: RELYPSA, INC., SANTA CLARA, CALIF., US |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |