DE69937108D1 - Verbindungen und Methoden zum Nachweis von Biomolekülen - Google Patents

Verbindungen und Methoden zum Nachweis von Biomolekülen

Info

Publication number
DE69937108D1
DE69937108D1 DE69937108T DE69937108T DE69937108D1 DE 69937108 D1 DE69937108 D1 DE 69937108D1 DE 69937108 T DE69937108 T DE 69937108T DE 69937108 T DE69937108 T DE 69937108T DE 69937108 D1 DE69937108 D1 DE 69937108D1
Authority
DE
Germany
Prior art keywords
methods
biomolecules
compounds
detection
photocleavable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69937108T
Other languages
English (en)
Other versions
DE69937108T2 (de
Inventor
Kenneth J Rothschild
Jerzy Olejnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ambergen Inc
Original Assignee
Ambergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambergen Inc filed Critical Ambergen Inc
Publication of DE69937108D1 publication Critical patent/DE69937108D1/de
Application granted granted Critical
Publication of DE69937108T2 publication Critical patent/DE69937108T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
DE69937108T 1998-06-02 1999-06-02 Verbindungen und Methoden zum Nachweis von Biomolekülen Expired - Lifetime DE69937108T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8764198P 1998-06-02 1998-06-02
US87641P 1998-06-02
US323424 1999-06-01
US09/323,424 US6218530B1 (en) 1998-06-02 1999-06-01 Compounds and methods for detecting biomolecules
PCT/US1999/012328 WO1999067619A2 (en) 1998-06-02 1999-06-02 Compounds and methods for detecting biomolecules

Publications (2)

Publication Number Publication Date
DE69937108D1 true DE69937108D1 (de) 2007-10-25
DE69937108T2 DE69937108T2 (de) 2008-06-12

Family

ID=22206377

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69937108T Expired - Lifetime DE69937108T2 (de) 1998-06-02 1999-06-02 Verbindungen und Methoden zum Nachweis von Biomolekülen

Country Status (7)

Country Link
US (1) US6218530B1 (de)
EP (1) EP1086251B1 (de)
AT (1) ATE373105T1 (de)
AU (1) AU759399B2 (de)
CA (2) CA2333987C (de)
DE (1) DE69937108T2 (de)
WO (1) WO1999067619A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060057565A1 (en) * 2000-09-11 2006-03-16 Jingyue Ju Combinatorial fluorescence energy transfer tags and uses thereof
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
WO2002029003A2 (en) 2000-10-06 2002-04-11 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
IL158487A0 (en) * 2001-05-18 2004-05-12 Wisconsin Alumni Res Found Method for the synthesis of dna sequences
EP1415001A4 (de) * 2001-07-13 2008-02-20 Ambergen Inc Photolytisch spaltbare marker enthaltende nukleotidzusammensetzungen und verfahren zur herstellung davon
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
EP3795577A1 (de) * 2002-08-23 2021-03-24 Illumina Cambridge Limited Modifizierte nukleotide
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US20050032081A1 (en) * 2002-12-13 2005-02-10 Jingyue Ju Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
US20040185473A1 (en) * 2002-12-17 2004-09-23 Affymetrix, Inc. Releasable polymer arrays
US20040248162A1 (en) * 2002-12-17 2004-12-09 Affymetrix, Inc. Releasable polymer arrays
WO2006073436A2 (en) * 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Mass tag pcr for multiplex diagnostics
US7547775B2 (en) * 2004-12-31 2009-06-16 Affymetrix, Inc. Parallel preparation of high fidelity probes in an array format
WO2007002204A2 (en) 2005-06-21 2007-01-04 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compostions
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US20090088332A1 (en) * 2005-11-21 2009-04-02 Jingyue Ju Multiplex Digital Immuno-Sensing Using a Library of Photocleavable Mass Tags
JP4984990B2 (ja) * 2006-03-28 2012-07-25 富士通株式会社 機能性分子の製造方法
WO2008042067A2 (en) 2006-09-28 2008-04-10 Illumina, Inc. Compositions and methods for nucleotide sequencing
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US9115163B2 (en) 2007-10-19 2015-08-25 The Trustees Of Columbia University In The City Of New York DNA sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators
EP4310194A2 (de) 2007-10-19 2024-01-24 The Trustees of Columbia University in the City of New York Entwurf und synthese von spaltbaren fluoreszierenden nukleotiden als reversible terminatoren zur dna-sequenzierung durch synthese
US20090286286A1 (en) * 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
US9347092B2 (en) * 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
US9523680B2 (en) 2010-06-30 2016-12-20 Ambergen, Inc. Global Proteomic screening of random bead arrays using mass spectrometry imaging
WO2012003478A2 (en) 2010-07-02 2012-01-05 Ventana Medical Systems, Inc. Detecting targets using mass tags and mass spectrometry
WO2012162429A2 (en) 2011-05-23 2012-11-29 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using raman and infrared spectroscopy detection
KR101874680B1 (ko) 2013-03-15 2018-07-04 일루미나 케임브리지 리미티드 변형된 뉴클레오사이드 또는 뉴클레오타이드
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
EP3372610A1 (de) * 2017-03-08 2018-09-12 ETH Zurich Neuartige phosphorylierungsreagenzien und verwendungen davon
WO2019104070A1 (en) * 2017-11-21 2019-05-31 Nanostring Technologies, Inc. O-nitrobenzyl photocleavable bifunctional linker
EP4237839A1 (de) 2020-10-29 2023-09-06 Ambergen, Inc. Neue photospaltbare massentags für die multiplexierte massenspektrometrische abbildung von geweben unter verwendung biomolekularer sonden

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258506A (en) * 1984-10-16 1993-11-02 Chiron Corporation Photolabile reagents for incorporation into oligonucleotide chains
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules

Also Published As

Publication number Publication date
CA2717107A1 (en) 1999-12-29
AU759399B2 (en) 2003-04-17
CA2333987C (en) 2011-01-18
EP1086251A4 (de) 2002-04-03
ATE373105T1 (de) 2007-09-15
WO1999067619A2 (en) 1999-12-29
EP1086251B1 (de) 2007-09-12
EP1086251A2 (de) 2001-03-28
US6218530B1 (en) 2001-04-17
WO1999067619A3 (en) 2000-04-20
DE69937108T2 (de) 2008-06-12
AU6238299A (en) 2000-01-10
CA2333987A1 (en) 1999-12-29

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