DE69935881D1 - Bis-Indolylmaleimide zur therapeutischen Behandlung von Nieren-Funktionsstörungen - Google Patents

Bis-Indolylmaleimide zur therapeutischen Behandlung von Nieren-Funktionsstörungen

Info

Publication number
DE69935881D1
DE69935881D1 DE69935881T DE69935881T DE69935881D1 DE 69935881 D1 DE69935881 D1 DE 69935881D1 DE 69935881 T DE69935881 T DE 69935881T DE 69935881 T DE69935881 T DE 69935881T DE 69935881 D1 DE69935881 D1 DE 69935881D1
Authority
DE
Germany
Prior art keywords
bis
indolylmaleimides
therapeutic treatment
renal dysfunction
dionehydrochloridesal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69935881T
Other languages
English (en)
Other versions
DE69935881T2 (de
Inventor
Douglas Kirk Ways
Richard Gilbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69935881D1 publication Critical patent/DE69935881D1/de
Application granted granted Critical
Publication of DE69935881T2 publication Critical patent/DE69935881T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69935881T 1998-03-05 1999-03-05 Bis-Indolylmaleimide zur therapeutischen Behandlung von Nieren-Funktionsstörungen Expired - Fee Related DE69935881T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7685298P 1998-03-05 1998-03-05
US76852P 1998-03-05

Publications (2)

Publication Number Publication Date
DE69935881D1 true DE69935881D1 (de) 2007-06-06
DE69935881T2 DE69935881T2 (de) 2008-01-10

Family

ID=22134578

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69935881T Expired - Fee Related DE69935881T2 (de) 1998-03-05 1999-03-05 Bis-Indolylmaleimide zur therapeutischen Behandlung von Nieren-Funktionsstörungen

Country Status (10)

Country Link
US (1) US6225301B1 (de)
EP (1) EP0951903B1 (de)
JP (1) JP2002505278A (de)
AT (1) ATE360416T1 (de)
AU (1) AU2904799A (de)
CA (1) CA2323172A1 (de)
DE (1) DE69935881T2 (de)
ES (1) ES2285814T3 (de)
WO (1) WO1999044599A1 (de)
ZA (1) ZA991784B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050250725A1 (en) * 2000-06-16 2005-11-10 Price Peter M Regulation of the P21 gene and uses thereof
WO2007143119A2 (en) * 2006-06-01 2007-12-13 The Board Of Trustees Of The Leland Stanford Junior University Method of preventing progression of hypertension-induced heart failure with pkc peptides
EP2177510A1 (de) 2008-10-17 2010-04-21 Universität des Saarlandes Allosterische Proteinkinasemodulatoren

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
US5624949A (en) 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
HU219709B (hu) 1993-12-07 2001-06-28 Eli Lilly And Co. Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények
DK0657411T3 (da) 1993-12-07 1999-11-15 Lilly Co Eli Forbedret syntese af bisindolylmaleimider
US5545636A (en) 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5616577A (en) * 1994-08-25 1997-04-01 Smithkline Beecham Corporation Protein Kinase C inhibitor
US5559228A (en) 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides
HU226821B1 (en) 1995-11-20 2009-11-30 Lilly Co Eli The mesylate salt of a macrocyclic bis-indolyl-maleimide derivative, process for its preparation, use thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
ZA991784B (en) 1999-12-13
ATE360416T1 (de) 2007-05-15
CA2323172A1 (en) 1999-09-10
WO1999044599A1 (en) 1999-09-10
US6225301B1 (en) 2001-05-01
ES2285814T3 (es) 2007-11-16
EP0951903B1 (de) 2007-04-25
AU2904799A (en) 1999-09-20
JP2002505278A (ja) 2002-02-19
EP0951903A1 (de) 1999-10-27
DE69935881T2 (de) 2008-01-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee