EA199900243A1 - Применение ингибиторов протеинкиназы с для производства лекарственного препарата для лечения инфекции, вызванной человеческим т-клеточным лимфотропным вирусом типа 1 - Google Patents

Применение ингибиторов протеинкиназы с для производства лекарственного препарата для лечения инфекции, вызванной человеческим т-клеточным лимфотропным вирусом типа 1

Info

Publication number
EA199900243A1
EA199900243A1 EA199900243A EA199900243A EA199900243A1 EA 199900243 A1 EA199900243 A1 EA 199900243A1 EA 199900243 A EA199900243 A EA 199900243A EA 199900243 A EA199900243 A EA 199900243A EA 199900243 A1 EA199900243 A1 EA 199900243A1
Authority
EA
Eurasian Patent Office
Prior art keywords
virus
human
treatment
infection
caused
Prior art date
Application number
EA199900243A
Other languages
English (en)
Inventor
Майкл Р. Джироусек
Дуглас К. Уэйс
Лоренс Е. Страмм
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900243A1 publication Critical patent/EA199900243A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Способ лечения инфекции, вызванной человеческим Т-клеточным лимфотропным вирусом типа 1, с использованием избирательного ингибитора ПКС, в частности с использованием избирательного к изоферменту ингибитора ПКС, хлористо-водородной соли (S)-3,4-[N,N'-1,1'-((2"-этокси)-3"'(О)-4'"-(N,N-диметиламино) бутан)-бис-(3,3'-индолил)]-1(Н)-пиррол-2,5-диона.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900243A 1996-08-30 1997-08-28 Применение ингибиторов протеинкиназы с для производства лекарственного препарата для лечения инфекции, вызванной человеческим т-клеточным лимфотропным вирусом типа 1 EA199900243A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2493896P 1996-08-30 1996-08-30
US08/917,517 US5962446A (en) 1996-08-30 1997-08-26 Therapetutic treatment for human T cell lymphotrophic virus type 1 infection
PCT/US1997/015524 WO1998008508A1 (en) 1996-08-30 1997-08-28 Use of pkc inhibitors for the manufacture of a medicament for the treatment of htlv-1 infections

Publications (1)

Publication Number Publication Date
EA199900243A1 true EA199900243A1 (ru) 1999-10-28

Family

ID=26699066

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900243A EA199900243A1 (ru) 1996-08-30 1997-08-28 Применение ингибиторов протеинкиназы с для производства лекарственного препарата для лечения инфекции, вызванной человеческим т-клеточным лимфотропным вирусом типа 1

Country Status (14)

Country Link
US (1) US5962446A (ru)
EP (1) EP0830861A1 (ru)
JP (1) JP2002514176A (ru)
KR (1) KR20000035864A (ru)
CN (1) CN1231608A (ru)
AU (1) AU4179397A (ru)
BR (1) BR9711366A (ru)
CA (1) CA2263161A1 (ru)
EA (1) EA199900243A1 (ru)
IL (1) IL128493A0 (ru)
NO (1) NO990948L (ru)
PL (1) PL331759A1 (ru)
TR (1) TR199900905T2 (ru)
WO (1) WO1998008508A1 (ru)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5063238A (en) * 1989-11-13 1991-11-05 Merrell Dow Pharmaceuticals Inc. Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
HU219709B (hu) * 1993-12-07 2001-06-28 Eli Lilly And Co. Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények
DK0657411T3 (da) * 1993-12-07 1999-11-15 Lilly Co Eli Forbedret syntese af bisindolylmaleimider
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors

Also Published As

Publication number Publication date
CN1231608A (zh) 1999-10-13
US5962446A (en) 1999-10-05
EP0830861A1 (en) 1998-03-25
NO990948D0 (no) 1999-02-26
NO990948L (no) 1999-04-28
PL331759A1 (en) 1999-08-02
WO1998008508A1 (en) 1998-03-05
JP2002514176A (ja) 2002-05-14
KR20000035864A (ko) 2000-06-26
AU4179397A (en) 1998-03-19
CA2263161A1 (en) 1998-03-05
BR9711366A (pt) 1999-08-17
IL128493A0 (en) 2000-01-31
TR199900905T2 (xx) 1999-07-21

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