DE69930137D1 - Verfahren zum screenen und herstellen von verbindungsbibliotheken - Google Patents

Verfahren zum screenen und herstellen von verbindungsbibliotheken

Info

Publication number
DE69930137D1
DE69930137D1 DE69930137T DE69930137T DE69930137D1 DE 69930137 D1 DE69930137 D1 DE 69930137D1 DE 69930137 T DE69930137 T DE 69930137T DE 69930137 T DE69930137 T DE 69930137T DE 69930137 D1 DE69930137 D1 DE 69930137D1
Authority
DE
Germany
Prior art keywords
absorption
compound library
test samples
screening
data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69930137T
Other languages
English (en)
Inventor
George M Grass
D Leesman
A Norris
J Sinko
E Wehrli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sygnis Pharma AG
Original Assignee
Lion Bioscience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Bioscience AG filed Critical Lion Bioscience AG
Application granted granted Critical
Publication of DE69930137D1 publication Critical patent/DE69930137D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G16C20/62—Design of libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Computing Systems (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Library & Information Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Biochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69930137T 1998-09-14 1999-09-14 Verfahren zum screenen und herstellen von verbindungsbibliotheken Expired - Lifetime DE69930137D1 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US10022498P 1998-09-14 1998-09-14
US10029098P 1998-09-14 1998-09-14
US10923298P 1998-11-18 1998-11-18
US10923498P 1998-11-18 1998-11-18
US32006999A 1999-05-26 1999-05-26
US09/320,371 US6647358B2 (en) 1998-09-14 1999-05-26 Pharmacokinetic-based drug design tool and method
US09/320,270 US20020035459A1 (en) 1998-09-14 1999-05-26 Pharmacokinetic-based drug design tool and method
US09/320,545 US6542858B1 (en) 1998-09-14 1999-05-26 Pharmacokinetic-based drug design tool and method
US09/320,372 US20010041964A1 (en) 1998-09-14 1999-05-26 Pharmacokinetic-based drug design tool and method
US09/320,544 US20020010550A1 (en) 1998-09-14 1999-05-26 Pharmacokinetic-based drug design tool and method
PCT/US1999/021151 WO2000016231A1 (en) 1998-09-14 1999-09-14 Method for screening and producing compound libraries

Publications (1)

Publication Number Publication Date
DE69930137D1 true DE69930137D1 (de) 2006-04-27

Family

ID=27536966

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930137T Expired - Lifetime DE69930137D1 (de) 1998-09-14 1999-09-14 Verfahren zum screenen und herstellen von verbindungsbibliotheken

Country Status (8)

Country Link
US (6) US20010041964A1 (de)
EP (2) EP1144675A4 (de)
JP (2) JP2003521673A (de)
AT (1) ATE319136T1 (de)
AU (2) AU767944B2 (de)
CA (2) CA2343914A1 (de)
DE (1) DE69930137D1 (de)
WO (2) WO2000015178A2 (de)

Families Citing this family (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1010487A6 (nl) * 1996-06-11 1998-10-06 Unilin Beheer Bv Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen.
US20040117125A1 (en) * 1999-04-26 2004-06-17 Hao Chen Drug discovery method and apparatus
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US20050089923A9 (en) * 2000-01-07 2005-04-28 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US7216113B1 (en) * 2000-03-24 2007-05-08 Symyx Technologies, Inc. Remote Execution of Materials Library Designs
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US6549803B1 (en) * 2000-05-08 2003-04-15 Image-Guided Neurologics Inc. Method and apparatus for targeting material delivery to tissue
WO2002010746A2 (en) * 2000-07-28 2002-02-07 Lion Bioscience Ag Pharmacokinetic tool and method for predicting metabolism of a compound in a mammal
US7319945B1 (en) * 2000-11-10 2008-01-15 California Institute Of Technology Automated methods for simulating a biological network
US7043415B1 (en) * 2001-01-31 2006-05-09 Pharsight Corporation Interactive graphical environment for drug model generation
US6937257B1 (en) * 2001-01-31 2005-08-30 Pharsight Corporation Unit tracking and notification in a graphical drug model editor
US20020111850A1 (en) * 2001-02-12 2002-08-15 Chevron Oronite Company Llc System and method for new product clearance and development
US6631291B2 (en) * 2001-05-18 2003-10-07 Instrumentarium Corp. Closed loop drug administration method and apparatus using EEG complexity for control purposes
CA2457408A1 (en) * 2001-07-13 2003-01-23 Pharmacopeia, Inc. System and method for aqueous solubility prediction
DE10142019A1 (de) * 2001-08-28 2003-03-20 Philips Corp Intellectual Pty Schaltungsanordnung zur Demodulation von Signalen
CA2496143A1 (en) * 2001-10-12 2003-04-17 University Of Utah Research Foundation Anesthesia drug monitor
US7027970B2 (en) * 2001-10-19 2006-04-11 Globomax Llc Tool for in vitro-in vivo correlation
US20030078760A1 (en) * 2001-10-19 2003-04-24 Globomax Holdings, Llc Population pharmacokinetic modeling and analysis (PDx-POP™)
US7415359B2 (en) * 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
US6799123B2 (en) * 2001-11-05 2004-09-28 Lyn Hughes Dissolution test equipment and method
DE10160270A1 (de) * 2001-12-07 2003-06-26 Bayer Ag Computersystem und Verfahren zur Berechnung von ADME-Eigenschaften
US20040110226A1 (en) * 2002-03-01 2004-06-10 Xencor Antibody optimization
CA2479072A1 (en) * 2002-03-12 2003-12-18 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
JP2005529158A (ja) * 2002-05-28 2005-09-29 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 両親媒性ポリマーのコンピュータ分析および設計のための方法、システムおよびコンピュータプログラム製品
DE60313339T2 (de) * 2002-07-31 2008-01-03 Critical Outcome Technologies, Inc. Protein tyrosin kinase inhibitoren
WO2004025393A2 (en) * 2002-09-16 2004-03-25 Optimata, Ltd. An interactive technique for optimizing drug development from the pre-clinical phases through phase-iv
ES2298563T3 (es) * 2002-10-09 2008-05-16 Critical Outcome Technologies, Inc. Inhibidores de proteinas tirosina cinasas.
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
DE10256315A1 (de) * 2002-12-03 2004-06-17 Bayer Ag Computersystem und Verfahren zur Berechnung eines pharmakokinetischen Verhaltens einer chemischen Substanz in Insekten
ATE439039T1 (de) * 2003-01-16 2009-08-15 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
EP1590743A1 (de) * 2003-01-21 2005-11-02 Alza Corporation Rechnerisches modell für die transdermale medikamentenverabreichung
EP1636351A4 (de) 2003-05-21 2007-04-04 Gen Hospital Corp Mikrofabrizierte zusammensetzungen und verfahren zur konstruktion von geweben mit mehreren zellarten
US7853406B2 (en) * 2003-06-13 2010-12-14 Entelos, Inc. Predictive toxicology for biological systems
AU2003903597A0 (en) * 2003-07-11 2003-07-24 Jakov Vaisman Treatment of premature ejaculation
US8346482B2 (en) * 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
DE10345836A1 (de) * 2003-10-02 2005-04-21 Bayer Technology Services Gmbh Verfahren zur Simulation der Wechselwirkung von chemischen Substanzen mit lebenden Organismen
JP4247101B2 (ja) * 2003-12-10 2009-04-02 株式会社東芝 設計支援システム
JP2005245667A (ja) * 2004-03-03 2005-09-15 Koninkl Philips Electronics Nv 薬剤投与設計システム
WO2005109343A2 (en) * 2004-05-10 2005-11-17 Philips Intellectual Property & Standards Gmbh Image data processing system for compartmental analysis
DE102004025534A1 (de) * 2004-05-25 2005-12-15 Bayer Technology Services Gmbh Verfahren zur (zweistufigen) Dosis- und Dosierungsfindung
WO2005116902A2 (en) * 2004-05-28 2005-12-08 Philips Intellectual Property & Standards Gmbh System for the noninvasive determination of tracer concentration in blood
CN1961322A (zh) * 2004-05-28 2007-05-09 皇家飞利浦电子股份有限公司 用于估计参照组织和目标区域中的示踪物浓度的系统
US20050278124A1 (en) * 2004-06-14 2005-12-15 Duffy Nigel P Methods for molecular property modeling using virtual data
US20060052943A1 (en) * 2004-07-28 2006-03-09 Karthik Ramani Architectures, queries, data stores, and interfaces for proteins and drug molecules
US8396670B2 (en) * 2004-08-16 2013-03-12 Venture Milling, Inc. Process, system and method for improving the determination of digestive effects upon an ingestable substance
US8232095B2 (en) * 2004-11-18 2012-07-31 The Regents Of The University Of California Apparatus and methods for manipulation and optimization of biological systems
DK1835959T3 (da) 2004-11-24 2013-03-25 Medrad Inc Indretninger, systemer og fremgangsmåder til afgivelse af fluidum
NZ555843A (en) * 2004-12-16 2010-01-29 Entelos Inc Methods and models for cholesterol metabolism
GB2439032B (en) * 2005-04-15 2010-10-20 Thermo Crs Ltd Method and system for sample testing
WO2006119325A2 (en) * 2005-05-02 2006-11-09 Plectix Biosystems, Inc. Using biological models
US7331251B2 (en) * 2005-06-22 2008-02-19 Idaho State University Dissolution testing of solid dosage forms intended to be administered in the oral cavity
JP2009507228A (ja) * 2005-08-31 2009-02-19 アフィーマックス・インコーポレイテッド プロキシマーカーを用いる生物学的流体およびその他の溶液マトリックス中の薬物の誘導体化および低レベル検出
CA2628108C (en) 2005-11-10 2020-01-07 In Silico Biosciences, Inc. Method and apparatus for computer modeling the human brain for predicting drug effects
DE102005061270A1 (de) * 2005-12-20 2007-06-28 Universität Hamburg Screening-Verfahren
EP1884878A1 (de) * 2006-08-02 2008-02-06 Hitachi Ltd. Computersystem zur Simulation eines physikalischen Systems
WO2008046045A1 (en) * 2006-10-12 2008-04-17 Cylene Pharmaceuticals, Inc. Drug biovailability screens
KR100856517B1 (ko) 2007-01-03 2008-09-04 주식회사 인실리코텍 수학적 모델을 이용한 펩타이드 서열의 조직 표적 예측시스템 및 방법과 그 프로그램을 저장한 기록매체
US9302044B2 (en) 2006-12-29 2016-04-05 Bayer Healthcare Llc Patient-based parameter generation systems for medical injection procedures
CA2673683C (en) 2007-01-11 2014-07-29 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
KR101459805B1 (ko) * 2007-03-30 2014-11-07 9898 리미티드 천연 산물 개발을 위한 약제 플랫폼 기법
US8718944B2 (en) * 2007-05-22 2014-05-06 Worcester Polytechnic Institute Patient-specific image-based computational modeling and techniques for human heart surgery optimization
US20090037539A1 (en) * 2007-08-02 2009-02-05 Telefonaktiebolaget Lm Ericsson (Publ) Methods and Systems for Message Interworking
US8738116B2 (en) * 2007-09-21 2014-05-27 National Research Council Of Canada Method and apparatus for periodontal diagnosis
CA2710039C (en) * 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
CA2710333A1 (en) * 2008-01-03 2009-07-09 Abbott Biotechnology Ltd. Predicting long-term efficacy of a compound in the treatment of psoriasis
CA2758393A1 (en) * 2008-04-18 2009-10-22 The University Of Manchester Imaging technique
US9662391B2 (en) * 2008-04-24 2017-05-30 The Invention Science Fund I Llc Side effect ameliorating combination therapeutic products and systems
US20100130811A1 (en) * 2008-04-24 2010-05-27 Searete Llc Computational system and method for memory modification
US9064036B2 (en) 2008-04-24 2015-06-23 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US8876688B2 (en) 2008-04-24 2014-11-04 The Invention Science Fund I, Llc Combination treatment modification methods and systems
US7974787B2 (en) 2008-04-24 2011-07-05 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US20090312668A1 (en) * 2008-04-24 2009-12-17 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100063368A1 (en) * 2008-04-24 2010-03-11 Searete Llc, A Limited Liability Corporation Computational system and method for memory modification
US8930208B2 (en) * 2008-04-24 2015-01-06 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US20100022820A1 (en) * 2008-04-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20090271375A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Combination treatment selection methods and systems
US9239906B2 (en) 2008-04-24 2016-01-19 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US20100030089A1 (en) * 2008-04-24 2010-02-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US8682687B2 (en) 2008-04-24 2014-03-25 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US20090271347A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring bioactive agent use
US9282927B2 (en) 2008-04-24 2016-03-15 Invention Science Fund I, Llc Methods and systems for modifying bioactive agent use
US8606592B2 (en) * 2008-04-24 2013-12-10 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US9026369B2 (en) * 2008-04-24 2015-05-05 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US20090271009A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Combination treatment modification methods and systems
US9649469B2 (en) * 2008-04-24 2017-05-16 The Invention Science Fund I Llc Methods and systems for presenting a combination treatment
US20090271122A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US20090270694A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US20100100036A1 (en) * 2008-04-24 2010-04-22 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and Method for Memory Modification
US20100076249A1 (en) * 2008-04-24 2010-03-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100017001A1 (en) * 2008-04-24 2010-01-21 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100042578A1 (en) * 2008-04-24 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100041958A1 (en) * 2008-04-24 2010-02-18 Searete Llc Computational system and method for memory modification
US20100125561A1 (en) * 2008-04-24 2010-05-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20100280332A1 (en) * 2008-04-24 2010-11-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring bioactive agent use
US20090270688A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting a combination treatment
US7801686B2 (en) * 2008-04-24 2010-09-21 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US9560967B2 (en) 2008-04-24 2017-02-07 The Invention Science Fund I Llc Systems and apparatus for measuring a bioactive agent effect
US20100069724A1 (en) * 2008-04-24 2010-03-18 Searete Llc Computational system and method for memory modification
US20100041964A1 (en) * 2008-04-24 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring and modifying a combination treatment
US20090270687A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for modifying bioactive agent use
US8615407B2 (en) * 2008-04-24 2013-12-24 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US20100081861A1 (en) * 2008-04-24 2010-04-01 Searete Llc Computational System and Method for Memory Modification
US20100081860A1 (en) * 2008-04-24 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and Method for Memory Modification
US20100015583A1 (en) * 2008-04-24 2010-01-21 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and method for memory modification
US20100004762A1 (en) * 2008-04-24 2010-01-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational system and method for memory modification
US20090269329A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Combination Therapeutic products and systems
US9449150B2 (en) 2008-04-24 2016-09-20 The Invention Science Fund I, Llc Combination treatment selection methods and systems
KR100946145B1 (ko) * 2008-05-13 2010-03-08 성균관대학교산학협력단 서열 유사도 측정 장치 및 그 제어방법
WO2010006438A1 (en) 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
WO2010048532A1 (en) * 2008-10-24 2010-04-29 Amicus Therapeutics, Inc. Multiple compartment dosing model
US20100169260A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US8738395B2 (en) * 2008-12-30 2014-05-27 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US20100166613A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163034A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US8725529B2 (en) * 2008-12-30 2014-05-13 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US20100163033A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US8706518B2 (en) * 2008-12-30 2014-04-22 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US8694330B2 (en) * 2008-12-30 2014-04-08 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US20100163038A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100168602A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US8712794B2 (en) * 2008-12-30 2014-04-29 The Invention Science Fund I, Llc Methods and systems for presenting an inhalation experience
US20100163027A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163025A1 (en) * 2008-12-30 2010-07-01 Searete Llc Methods and systems for presenting an inhalation experience
US20100168529A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163036A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100169259A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100168525A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for presenting an inhalation experience
US20100163024A1 (en) * 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Methods and systems for presenting an inhalation experience
EP2435831B1 (de) 2009-05-29 2014-11-26 Carl A. Wesolowski Verfahren zur bewertung der nierenfunktion
NZ624935A (en) 2009-10-19 2016-01-29 Theranos Inc Integrated health data capture and analysis system
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
KR101298303B1 (ko) * 2010-04-27 2013-08-20 울산대학교 산학협력단 약물의 약동-약력학적 모델링을 위한 통합 분석 시스템
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
AU2011270772C1 (en) * 2010-06-24 2017-04-20 Bayer Healthcare Llc Modeling of pharmaceutical propagation and parameter generation for injection protocols
EP2609209A4 (de) * 2010-08-25 2018-02-14 Optibrium Ltd Auswahl von verbindungen in der wirkstoffforschung
DE102010060311B3 (de) * 2010-11-02 2012-02-02 Freie Universität Berlin Verfahren zur Unterstützung klinischer Studien
CN103370729B (zh) 2010-12-15 2020-02-07 皇家飞利浦电子股份有限公司 用于图像处理的系统和方法
CN103077296B (zh) * 2011-10-25 2015-11-18 复旦大学附属华山医院 基于流速调节的静脉注射药动学模型的体外模拟方法
DE102011085180A1 (de) * 2011-10-25 2013-04-25 Piramal Imaging Sa Verfahren zur Erzeugung optimierter Tomografie-Aufnahmen
CN102682209B (zh) * 2012-05-03 2014-11-05 桂林理工大学 有机污染物定量结构活性相关建模的变量筛选方法
DK3489667T3 (da) 2012-05-14 2021-08-02 Bayer Healthcare Llc Systemer og fremgangsmåder til bestemmelse af protokoller for farmaceutisk væskeinjektion baseret på røntgenrørsspænding
EP2880600A2 (de) * 2012-08-02 2015-06-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften Verfahren und computeranlage zur modellierung eines primatengehirns
US20160335412A1 (en) * 2013-01-30 2016-11-17 Geoffrey Tucker Systems and methods for predicting and adjusting the dosage of medicines in individual patients
US20150147738A1 (en) * 2013-03-13 2015-05-28 Bowling Green State University Methods and systems for teaching biological pathways
WO2015017798A2 (en) 2013-08-02 2015-02-05 CRIXlabs, Inc. Method and system for predicting spatial and temporal distributions of therapeutic substance carriers
EP2911075A1 (de) * 2014-02-25 2015-08-26 LTS LOHMANN Therapie-Systeme AG System zur Bestimmung einer Eignung eines Wirkstoffs für die transdermale oder transmukosale Applikation sowie entsprechendes Verfahren
TW201618795A (zh) * 2014-04-15 2016-06-01 波泰里斯股份有限公司 用以改良器官功能及延長器官移植物壽命之系統及方法
WO2015183920A2 (en) * 2014-05-28 2015-12-03 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
US11195594B2 (en) 2015-02-17 2021-12-07 Cipherome, Inc. Method for selecting anticancer agent based on protein damage information of individual to prevent anticancer agent side effects
CA2976320C (en) * 2015-07-29 2019-02-19 Synaptive Medical (Barbados) Inc. Method, system and apparatus for adjusting image data to compensate for modality-induced distortion
AU2017250570B2 (en) 2016-04-15 2024-07-25 Takeda Pharmaceutical Company Limited Method and apparatus for providing a pharmacokinetic drug dosing regiment
CN116790476A (zh) 2016-05-05 2023-09-22 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
US11478125B2 (en) 2016-06-30 2022-10-25 Given Imaging Ltd. Systems and methods for assessment and monitoring of a mucosal disease in a subjects gastrointestinal tract
WO2018106628A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
WO2019104101A1 (en) * 2017-11-21 2019-05-31 Verisim Life Inc. Systems and methods for full body circulation and drug concentration prediction
US11468973B2 (en) * 2018-02-02 2022-10-11 Richard Postrel Leveraging genomic, phenotypic and pharmacological data to cure disease
US20210183467A1 (en) * 2018-07-03 2021-06-17 Yale University System and method for using microbiome to de-risk drug development
US11580275B1 (en) * 2018-12-18 2023-02-14 X Development Llc Experimental discovery processes
EP3683800A1 (de) * 2019-01-18 2020-07-22 Tata Consultancy Services Limited Verfahren und system für insilico-design und prüfung von formulierungen unter verwendung eines physiochemischen hautmodells
US12100515B2 (en) 2019-07-11 2024-09-24 International Business Machines Corporation Altering a targeted brain therapeutic based on a brain circuit model
US20210050108A1 (en) * 2019-07-19 2021-02-18 Tata Consultancy Services Limited Systems and methods for generating optimized set of pharmacokinetic (pk) and pharmacodynamic (pd) parameters
CN110766084B (zh) * 2019-10-28 2021-06-15 北京理工大学 基于cae与hl-cnn的小样本sar目标识别方法
JP7302621B2 (ja) * 2021-04-02 2023-07-04 株式会社豊田中央研究所 有機材料輸送特性評価装置及び有機材料輸送特性評価方法
WO2022244022A1 (en) * 2021-05-21 2022-11-24 Aizen Algo Private Limited Method and system for prediction of time points in pharmacokinetic studies
WO2022248703A2 (en) 2021-05-27 2022-12-01 Cyprus University Of Technology Physiologically based toxicokinetic (pbtk) modeling for implant toxicology

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335438A (en) 1980-04-17 1982-06-15 Smolen Victor F Method and apparatus for automatic dissolution testing of products
US4411989A (en) 1981-08-13 1983-10-25 Midwest Research Institute Processes and devices for detection of substances such as enzyme inhibitors
GB2206429A (en) 1987-07-02 1989-01-05 Infrared Eng System determining properties or identity of a sample
US4775794A (en) 1987-11-02 1988-10-04 Zenon Environmental Inc. Process and apparatus for measurement of light-absorbable components dissolved in liquids
US4975581A (en) 1989-06-21 1990-12-04 University Of New Mexico Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5680590A (en) 1990-09-21 1997-10-21 Parti; Michael Simulation system and method of using same
US5331573A (en) 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
US5387421A (en) 1991-01-31 1995-02-07 Tsrl, Inc. Multi stage drug delivery system
US5326778A (en) 1992-03-03 1994-07-05 Research Corporation Technologies, Inc. Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy
US5956501A (en) 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
DE69332782T2 (de) 1993-04-20 2003-12-18 Tsrl, Inc. Mehrstufiges arzneistoffabgabesystem
US5703792A (en) 1993-05-21 1997-12-30 Arris Pharmaceutical Corporation Three dimensional measurement of molecular diversity
US5569452A (en) 1993-08-31 1996-10-29 Tsrl, Inc. Pharmaceutical formulation having enhanced bile acid binding affinity
AU1297995A (en) 1993-11-26 1995-06-13 Lawrence B Hendry Design of drugs involving receptor-ligand-dna interactions
AU1562895A (en) * 1994-01-12 1995-08-01 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors
US5625579A (en) 1994-05-10 1997-04-29 International Business Machines Corporation Stochastic simulation method for processes containing equilibrium steps
AU2788695A (en) 1994-10-28 1996-05-23 Neurosearch A/S Patch clamp apparatus and technique having high throughput and low fluid volume requirements
US5792833A (en) 1994-12-22 1998-08-11 New England Medical Center Hospitals, Inc. E2 binding proteins
WO1996022574A1 (en) 1995-01-20 1996-07-25 The Board Of Trustees Of The Leland Stanford Junior University System and method for simulating operation of biochemical systems
US5699268A (en) 1995-03-24 1997-12-16 University Of Guelph Computational method for designing chemical structures having common functional characteristics
US5657255C1 (en) 1995-04-14 2002-06-11 Interleukin Genetics Inc Hierarchic biological modelling system and method
AU7525996A (en) 1995-11-03 1997-05-22 Eli Lilly And Company Automated permeability analysis system
JP2000502440A (ja) 1995-12-07 2000-02-29 スクリプトジェン・ファーマスーティカルズ，インコーポレイテッド リガンドを識別するための蛍光に基づくスクリーニング方法
US5783397A (en) 1995-12-11 1998-07-21 Northeastern University Screening natural samples for new therapeutic compounds using capillary electrophoresis
WO1997029091A1 (en) 1996-02-09 1997-08-14 Phytera Symbion Aps Balanol analogues
US5880972A (en) 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
EP0950184A1 (de) 1996-06-27 1999-10-20 Cellstat Technologies, Inc. Verfahren und vorrichtung zum sieben mit hohem durchsatz
EP0907412B1 (de) 1996-06-28 2008-08-27 Caliper Life Sciences, Inc. Hochdurchsatz-screening-testsystem mittels mikrofluidischer vorrichtungen
EP0818744A3 (de) 1996-07-08 1998-07-08 Proteus Molecular Design Limited Verfahren zur Auswahl von Kandidat-Drogenverbindungen
EP0923733A1 (de) 1996-08-29 1999-06-23 Chiron Corporation Verfahren zur analyse von absorptions-, verteilungs-, metabolismus-, ausscheidungs-, und pharmakokinetikeigenschaften einer mischung aus mehreren verbindungen
US5854992A (en) 1996-09-26 1998-12-29 President And Fellows Of Harvard College System and method for structure-based drug design that includes accurate prediction of binding free energy
CA2280096A1 (en) 1997-02-04 1998-08-06 The Regents Of The University Of California Nanomolar, non-peptide inhibitors of cathepsin d
EP0918296A1 (de) 1997-11-04 1999-05-26 Cerep Verfahren zum virtuellen Wiederauffinden von Analogen von Bleiverbindungen durch Erzeugen von potentiellen Bibliotheken

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