DE69919702D1 - Verfahren zur Bestimmung der Blutgerinnung in Plasma - Google Patents

Verfahren zur Bestimmung der Blutgerinnung in Plasma

Info

Publication number
DE69919702D1
DE69919702D1 DE69919702T DE69919702T DE69919702D1 DE 69919702 D1 DE69919702 D1 DE 69919702D1 DE 69919702 T DE69919702 T DE 69919702T DE 69919702 T DE69919702 T DE 69919702T DE 69919702 D1 DE69919702 D1 DE 69919702D1
Authority
DE
Germany
Prior art keywords
blood
clotting
cti
plasma
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69919702T
Other languages
English (en)
Other versions
DE69919702T2 (de
Inventor
G Mann
D Rand
Kevin M Cawthern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Vermont
Original Assignee
University of Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Vermont filed Critical University of Vermont
Publication of DE69919702D1 publication Critical patent/DE69919702D1/de
Application granted granted Critical
Publication of DE69919702T2 publication Critical patent/DE69919702T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DE69919702T 1998-06-08 1999-06-08 Verfahren zur Bestimmung der Blutgerinnung in Plasma Expired - Lifetime DE69919702T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8848898P 1998-06-08 1998-06-08
US88488P 1998-06-08
PCT/US1999/012631 WO1999064622A1 (en) 1998-06-08 1999-06-08 Inhibition of coagulation in blood and blood products

Publications (2)

Publication Number Publication Date
DE69919702D1 true DE69919702D1 (de) 2004-09-30
DE69919702T2 DE69919702T2 (de) 2005-09-15

Family

ID=22211667

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919702T Expired - Lifetime DE69919702T2 (de) 1998-06-08 1999-06-08 Verfahren zur Bestimmung der Blutgerinnung in Plasma

Country Status (8)

Country Link
US (2) US6403381B1 (de)
EP (1) EP1084270B1 (de)
JP (1) JP2002517739A (de)
AT (1) ATE274600T1 (de)
AU (1) AU757459B2 (de)
CA (1) CA2333890A1 (de)
DE (1) DE69919702T2 (de)
WO (1) WO1999064622A1 (de)

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* Cited by examiner, † Cited by third party
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EP1084270B1 (de) * 1998-06-08 2004-08-25 The University Of Vermont And State Agricultural College Verfahren zur Bestimmung der Blutgerinnung in Plasma
AU6369700A (en) * 1999-07-23 2001-02-13 Coagulation Diagnostics, Incorporated Method for measuring coagulant factor activity in whole blood
US20020116222A1 (en) * 2000-10-22 2002-08-22 Standing Stone, Inc. Method and system for administering anticoagulation therapy
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
US6743596B1 (en) * 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
US6645768B1 (en) * 2000-10-27 2003-11-11 Biomerieux, Inc. Reagent and kit for determining global coagulability and hemostatic potential
US7358337B2 (en) * 2002-08-16 2008-04-15 International Technidyne Corporation Assay for low molecular weight heparin
WO2005017486A2 (en) * 2003-06-09 2005-02-24 Mann Kenneth G A global test of the hemostatic system
CA2566411A1 (en) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities
CA2591786C (en) 2004-12-23 2013-07-16 Bernhard Nieswandt Prevention of thrombus formation and/or stabilization
WO2007044278A2 (en) * 2005-10-05 2007-04-19 Gurbel Paul A The detection of restenosis risk in patients receiving a stent
US8197420B2 (en) 2006-12-18 2012-06-12 Magnolia Medical Technologies, Inc. Systems and methods for parenterally procuring bodily-fluid samples with reduced contamination
US8574849B2 (en) * 2007-10-03 2013-11-05 The University Of Vermont And State Agriculture College Methods of detection of factor XIa and tissue factor
CA2966011C (en) 2008-10-15 2021-10-19 Ionis Pharmaceuticals, Inc. Modulation of factor 11 expression
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
WO2012159021A2 (en) * 2011-05-19 2012-11-22 Hemosonics, Llc Portable hemostasis analyzer
CN102262161B (zh) * 2011-08-16 2013-09-11 天津市百利康泰生物技术有限公司 水蛭素在特定条件下失活后检测凝血四项方面的应用
JP6491880B2 (ja) * 2011-08-23 2019-03-27 シナプス・ビー．ブイ．Ｓｙｎａｐｓｅ Ｂ．Ｖ． 異物表面との接触による血液凝固系の活性化の熱安定性阻害剤
US8864684B2 (en) 2011-10-13 2014-10-21 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US8535241B2 (en) 2011-10-13 2013-09-17 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US20130149386A1 (en) * 2011-12-07 2013-06-13 Region Nordjylland Cd36 as biomarker for steatosis
US9022951B2 (en) 2012-05-30 2015-05-05 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US9060724B2 (en) 2012-05-30 2015-06-23 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
WO2014022275A1 (en) 2012-08-01 2014-02-06 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
EP3318295B1 (de) 2012-10-11 2021-04-14 Magnolia Medical Technologies, Inc. System zur abgabe eines fluids an einen patienten mit reduzierter kontamination
CN109171766A (zh) 2012-11-30 2019-01-11 木兰医药技术股份有限公司 体液隔绝装置和使用体液隔绝装置隔绝体液的方法
US10772548B2 (en) 2012-12-04 2020-09-15 Magnolia Medical Technologies, Inc. Sterile bodily-fluid collection device and methods
EP4218575A3 (de) 2012-12-04 2023-09-06 Magnolia Medical Technologies, Inc. Sterile körperflüssigkeitsentnahmevorrichtung und verfahren
JP2016505159A (ja) * 2013-02-01 2016-02-18 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 接触経路抑制添加剤を含む血液採集装置
CN105188534B (zh) 2013-03-12 2018-05-29 木兰医药技术股份有限公司 用于选择性地阻塞针体的管腔的设备和方法
US20150050677A1 (en) * 2013-08-16 2015-02-19 University Of Massachusetts Medical School Methods and systems for measuring whole blood platelet reactivity
RU2556116C2 (ru) 2013-11-28 2015-07-10 Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") Высокоселективный ингибитор контактной активации на основе инфестина 4
US10123783B2 (en) 2014-03-03 2018-11-13 Magnolia Medical Technologies, Inc. Apparatus and methods for disinfection of a specimen container
US11234626B2 (en) 2015-06-12 2022-02-01 Magnolia Medical Technologies, Inc. Devices and methods for syringe-based fluid transfer for bodily-fluid sampling
EP3733067B1 (de) 2015-09-03 2023-06-14 Magnolia Medical Technologies, Inc. System zum aufrechterhalten der sterilität eines probenbehälters
WO2017189294A1 (en) 2016-04-25 2017-11-02 Instrumentation Laboratory Company Method and kit for identifying lupus anticoagulant (la) associated with antiphospholipid syndrome
CN116250868A (zh) 2017-09-12 2023-06-13 木兰医药技术股份有限公司 流体控制装置及其使用方法
US11419531B2 (en) 2017-12-07 2022-08-23 Magnolia Medical Technologies, Inc. Fluid control devices and methods of using the same
BR112020020957B1 (pt) 2018-05-09 2022-05-10 Ionis Pharmaceuticals, Inc Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos
EP3920801A1 (de) 2019-02-08 2021-12-15 Magnolia Medical Technologies, Inc. Vorrichtungen und verfahren zur sammlung und verteilung von körperflüssigkeiten
CN113784793B (zh) 2019-03-11 2023-09-19 木兰医药技术股份有限公司 流体控制装置及其使用方法
CN113325185B (zh) * 2021-07-09 2024-04-19 重庆鼎润医疗器械有限责任公司 多水平质控品及其制备方法和在血栓弹力图检测上的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882272A (en) 1986-10-01 1989-11-21 Temple University - Of The Commonwealth System Of Higher Education High molecular weight kininogen assay
US5318910A (en) 1988-11-10 1994-06-07 International Technidyne Corp. Standard whole blood composition for determining the potency of blood clotting inhibitory substances
US5472850A (en) 1991-04-10 1995-12-05 Oklahoma Medical Research Foundation Quantitative clotting assay for activated factor VII
US5314826A (en) 1991-08-23 1994-05-24 Medtronic Hemotec, Inc. Platelet activation and function evaluation technique
US5705395A (en) 1994-11-14 1998-01-06 The Scripps Research Institute Method for diagnosis of thrombotic disorders
EP1084270B1 (de) * 1998-06-08 2004-08-25 The University Of Vermont And State Agricultural College Verfahren zur Bestimmung der Blutgerinnung in Plasma

Also Published As

Publication number Publication date
EP1084270B1 (de) 2004-08-25
EP1084270A1 (de) 2001-03-21
EP1084270A4 (de) 2001-12-05
US6566140B2 (en) 2003-05-20
WO1999064622A1 (en) 1999-12-16
US20020042144A1 (en) 2002-04-11
AU4548699A (en) 1999-12-30
US6403381B1 (en) 2002-06-11
DE69919702T2 (de) 2005-09-15
CA2333890A1 (en) 1999-12-16
AU757459B2 (en) 2003-02-20
ATE274600T1 (de) 2004-09-15
JP2002517739A (ja) 2002-06-18

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