DE69919695D1 - Texaphyrin-konjugate und ihre anwendiung - Google Patents

Texaphyrin-konjugate und ihre anwendiung

Info

Publication number
DE69919695D1
DE69919695D1 DE69919695T DE69919695T DE69919695D1 DE 69919695 D1 DE69919695 D1 DE 69919695D1 DE 69919695 T DE69919695 T DE 69919695T DE 69919695 T DE69919695 T DE 69919695T DE 69919695 D1 DE69919695 D1 DE 69919695D1
Authority
DE
Germany
Prior art keywords
conjugates
platinum
texaphyrine
texaphyrin
neovascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69919695T
Other languages
English (en)
Other versions
DE69919695T2 (de
Inventor
L Sessler
Darren Magda
Tarak Mody
Pavel Anzenbacher
Joan Carvalho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacyclics LLC
University of Texas System
Original Assignee
Pharmacyclics LLC
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics LLC, University of Texas System filed Critical Pharmacyclics LLC
Application granted granted Critical
Publication of DE69919695D1 publication Critical patent/DE69919695D1/de
Publication of DE69919695T2 publication Critical patent/DE69919695T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DE69919695T 1998-06-05 1999-06-04 Texaphyrin-konjugate und ihre anwendiung Expired - Fee Related DE69919695T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8821498P 1998-06-05 1998-06-05
US88214P 1998-06-05
PCT/US1999/012614 WO1999062551A1 (en) 1998-06-05 1999-06-04 Texaphyrin conjugates and uses thereof

Publications (2)

Publication Number Publication Date
DE69919695D1 true DE69919695D1 (de) 2004-09-30
DE69919695T2 DE69919695T2 (de) 2005-09-15

Family

ID=22210058

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919695T Expired - Fee Related DE69919695T2 (de) 1998-06-05 1999-06-04 Texaphyrin-konjugate und ihre anwendiung

Country Status (10)

Country Link
US (1) US6207660B1 (de)
EP (1) EP1082138B1 (de)
JP (1) JP2002516878A (de)
KR (1) KR20010052616A (de)
AT (1) ATE274357T1 (de)
AU (1) AU4232199A (de)
CA (1) CA2334809A1 (de)
DE (1) DE69919695T2 (de)
NO (1) NO20006155L (de)
WO (1) WO1999062551A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US20060025726A1 (en) * 1996-06-04 2006-02-02 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with pharmacologically active layer
US20060052757A1 (en) * 1996-06-04 2006-03-09 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with analgesic or anesthetic
US20060030826A1 (en) * 1996-06-04 2006-02-09 Vance Products Incorporated,d/b/a Cook Urological Incorporated Implantable medical device with anti-neoplastic drug
US20020155999A1 (en) * 1998-04-30 2002-10-24 Han In Suk Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer
GB9904386D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
AU4679900A (en) * 1999-04-30 2000-11-17 Slil Biomedical Corporation Conformationally restricted polyamine analogs as disease therapies
EP1223982A2 (de) * 1999-10-29 2002-07-24 Pharmacyclics, Inc. Konjugate zur behandlung von atheroma und andere erkrankungen
HUP0303719A2 (hu) * 2000-10-16 2004-03-01 Neopharm, Inc. Mitoxantron hatóanyag-tartalmú liposzómás gyógyszerkészítmények és eljárás az előállításukra
JP2004513136A (ja) * 2000-11-08 2004-04-30 スリル　バイオメディカル　コーポレーション 抗癌剤として有用な新規ポリアミンアナログ−アミノ酸結合体
US6485704B1 (en) * 2001-05-04 2002-11-26 Mallinckrodt Inc. Azo compound for type I pototherapy
US20030082101A1 (en) * 2001-06-11 2003-05-01 Cavalier Discovery Accelerators for increasing the rate of formation of free radicals and reactive oxygen species
US20050261171A1 (en) * 2001-12-13 2005-11-24 Pharmacyclics, Inc. Combination cancer therapy
AU2002351382A1 (en) * 2001-12-13 2003-06-23 Pharmacyclics, Inc. Combination cancer therapy
US7026347B2 (en) * 2002-06-26 2006-04-11 Cellgate, Inc. Porphyrin-polyamine conjugates for cancer therapy
US20040192665A1 (en) * 2002-08-02 2004-09-30 Slil Biomedical Corporation Conjugates of porphyrin compounds with chemotherapeutic agents
US20090299263A1 (en) * 2002-08-28 2009-12-03 Nomir Medical Technologies, Inc. Near-Infrared electromagnetic modification of cellular steady-state membrane potentials
EP2161037A3 (de) * 2003-04-22 2010-05-26 Ipsen Pharma Camptothecin-Somatostatin Konjugaten
NZ546896A (en) * 2003-10-07 2010-01-29 Univ Western Sydney Sequence selective pyrrole and imidazole polyamide metallocomplexes
US8710020B2 (en) * 2004-04-02 2014-04-29 The University Of British Columbia Clusterin antisense therapy for treatment of cancer
US20080063605A1 (en) * 2004-05-20 2008-03-13 Wai-Fung Cheong Method of Enhancing Visualization of Atherosclerotic Plaque
DE102005055358A1 (de) * 2005-11-21 2007-05-24 Robert Bosch Gmbh Vorrichtung und Verfahren zum Aufrichten und Übergeben von Faltschachteln
US8133474B2 (en) * 2006-09-15 2012-03-13 Massachusetts Institute Of Technology Sensors for fluorescence and magnetic resonance imaging
KR100800391B1 (ko) 2007-04-06 2008-02-01 김익중 균열방지용 황토미장 시공방법
US20090062724A1 (en) * 2007-08-31 2009-03-05 Rixen Chen System and apparatus for sonodynamic therapy
AU2015274589B2 (en) * 2014-06-11 2020-12-03 Board Of Regents, The University Of Texas System Texaphyrin-Pt(IV) conjugates and compositions for use in overcoming platinum resistance
AU2021326545A1 (en) 2020-08-14 2023-03-09 Board Of Regents, The University Of Texas System Texaphyrin derivatives for manganese chemotherapy, photoacoustic imaging, and photothermal therapy
CN114539552B (zh) * 2022-03-31 2023-05-02 西安交通大学 一种铂基卟啉金属笼及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5457195A (en) * 1989-12-21 1995-10-10 Board Of Regents, The University Of Texas System Sapphyrin derivatives and conjugates
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物
JPH05507518A (ja) * 1990-05-15 1993-10-28 ダイアトロン・コーポレイション 蛍光ジゴキシン試薬用のフタロシアナトポリエチレングリコールおよびフタロシアナトサッカリド
US5595726A (en) * 1992-01-21 1997-01-21 Pharmacyclics, Inc. Chromophore probe for detection of nucleic acid
US5565552A (en) * 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5888997A (en) * 1994-04-14 1999-03-30 Pharmacyclics, Inc. Radiation sensitization using texaphyrins
WO1997019938A1 (es) * 1995-11-29 1997-06-05 Consejo Superior Investigaciones Cientificas Derivados fluorescentes de paclitaxel y docetaxel con actividad antineoplasica, metodo para obtenerlos y sus aplicaciones
JP4172726B2 (ja) * 1996-05-22 2008-10-29 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
GB9710049D0 (en) * 1997-05-19 1997-07-09 Nycomed Imaging As Method
DE19824653A1 (de) * 1998-02-25 1999-08-26 Schering Ag Nekrose-affine Verbindungen und ihre Verwendung zur Herstellung von Präparaten zur Pharmakotherapie

Also Published As

Publication number Publication date
EP1082138A1 (de) 2001-03-14
CA2334809A1 (en) 1999-12-09
US6207660B1 (en) 2001-03-27
ATE274357T1 (de) 2004-09-15
WO1999062551A1 (en) 1999-12-09
KR20010052616A (ko) 2001-06-25
AU4232199A (en) 1999-12-20
DE69919695T2 (de) 2005-09-15
NO20006155D0 (no) 2000-12-04
JP2002516878A (ja) 2002-06-11
NO20006155L (no) 2001-02-02
EP1082138B1 (de) 2004-08-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee