DE69918128D1 - Mutierte gewebefaktor-inhibitor (tfpi), dna sequenz davon und verwendung zur erkennung von thrombotischen erkrankungen - Google Patents
Mutierte gewebefaktor-inhibitor (tfpi), dna sequenz davon und verwendung zur erkennung von thrombotischen erkrankungenInfo
- Publication number
- DE69918128D1 DE69918128D1 DE69918128T DE69918128T DE69918128D1 DE 69918128 D1 DE69918128 D1 DE 69918128D1 DE 69918128 T DE69918128 T DE 69918128T DE 69918128 T DE69918128 T DE 69918128T DE 69918128 D1 DE69918128 D1 DE 69918128D1
- Authority
- DE
- Germany
- Prior art keywords
- tfpi
- dna sequence
- tissue factor
- muted
- thrombotic diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 title abstract 3
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 title abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 102000002262 Thromboplastin Human genes 0.000 title 1
- 108010000499 Thromboplastin Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001732 thrombotic effect Effects 0.000 title 1
- 208000007536 Thrombosis Diseases 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98115957 | 1998-08-25 | ||
| EP98115957 | 1998-08-25 | ||
| PCT/EP1999/006054 WO2000011034A1 (en) | 1998-08-25 | 1999-08-18 | A mutant of tissue factor pathway inhibitor, dna sequence and use for detecting thrombotic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69918128D1 true DE69918128D1 (de) | 2004-07-22 |
| DE69918128T2 DE69918128T2 (de) | 2005-07-14 |
Family
ID=8232503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69918128T Expired - Fee Related DE69918128T2 (de) | 1998-08-25 | 1999-08-18 | Mutierte gewebefaktor-inhibitor (tfpi), dna sequenz davon und verwendung zur erkennung von thrombotischen erkrankungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6521410B1 (de) |
| EP (1) | EP1105423B1 (de) |
| AT (1) | ATE269356T1 (de) |
| AU (1) | AU5736899A (de) |
| CA (1) | CA2340460A1 (de) |
| DE (1) | DE69918128T2 (de) |
| WO (1) | WO2000011034A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436302B1 (en) * | 1999-08-23 | 2002-08-20 | Applied Materials, Inc. | Post CU CMP polishing for reduced defects |
| US7879543B2 (en) | 2003-11-17 | 2011-02-01 | Luminex Molecular Diagnostics, Inc. | Method of detecting mutations associated with thrombosis |
| WO2006066960A1 (en) * | 2004-12-23 | 2006-06-29 | Ludwig-Maximilians- Universität München | Variant tfpi with increased anti-thrombotic activity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL104324A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
-
1999
- 1999-08-18 EP EP99944432A patent/EP1105423B1/de not_active Expired - Lifetime
- 1999-08-18 AT AT99944432T patent/ATE269356T1/de not_active IP Right Cessation
- 1999-08-18 US US09/763,565 patent/US6521410B1/en not_active Expired - Fee Related
- 1999-08-18 WO PCT/EP1999/006054 patent/WO2000011034A1/en not_active Ceased
- 1999-08-18 DE DE69918128T patent/DE69918128T2/de not_active Expired - Fee Related
- 1999-08-18 CA CA002340460A patent/CA2340460A1/en not_active Abandoned
- 1999-08-18 AU AU57368/99A patent/AU5736899A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1105423A1 (de) | 2001-06-13 |
| US6521410B1 (en) | 2003-02-18 |
| ATE269356T1 (de) | 2004-07-15 |
| EP1105423B1 (de) | 2004-06-16 |
| DE69918128T2 (de) | 2005-07-14 |
| WO2000011034A1 (en) | 2000-03-02 |
| CA2340460A1 (en) | 2000-03-02 |
| AU5736899A (en) | 2000-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |