DE69909848D1 - METHOD FOR PRODUCING SUBSTITUTED ALLYLAMINE DERIVATIVES AND THEIR SALTS - Google Patents

METHOD FOR PRODUCING SUBSTITUTED ALLYLAMINE DERIVATIVES AND THEIR SALTS

Info

Publication number
DE69909848D1
DE69909848D1 DE69909848T DE69909848T DE69909848D1 DE 69909848 D1 DE69909848 D1 DE 69909848D1 DE 69909848 T DE69909848 T DE 69909848T DE 69909848 T DE69909848 T DE 69909848T DE 69909848 D1 DE69909848 D1 DE 69909848D1
Authority
DE
Germany
Prior art keywords
formula
salts
hydrochloride
precipitate
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69909848T
Other languages
German (de)
Other versions
DE69909848T2 (en
Inventor
Peter Bod
Laszlo Terdy
Ferenc Trischler
Eva Fekecs
Maria Demeter
Anna Lauko
Gyoergy Domany
Komlosi Gyoergyi Szabone
Katalin Varga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10991303&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69909848(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of DE69909848D1 publication Critical patent/DE69909848D1/en
Publication of DE69909848T2 publication Critical patent/DE69909848T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings

Abstract

The antifungal agent (E)-N-methyl-N-(1-naphthylmethyl)-6,6-dimethyl-hept-2-ene-4-ynyl-1-amine of formula (I)and acid addition salts thereof are prepared by reacting a chloro-compound of formula (IIIb)with a secondary amine of formula (II)in an aliphatic ketone-type solvent in the presence of a base and optionally iodide salt catalyst, and subsequently treating the resulting reaction mixture directly with aqueous hydrochloric acid to precipitate the hydrochloride of the compound of formula (I). The precipitate is separated, and the base of formula (I) can be liberated from the hydrochloride and can be converted into other pharmaceutically acceptable acid addition salts.
DE69909848T 1999-10-22 1999-10-22 METHOD FOR PRODUCING SUBSTITUTED ALLYLAMINE DERIVATIVES AND THEIR SALTS Expired - Lifetime DE69909848T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/HU1999/000071 WO2001028976A1 (en) 1999-10-22 1999-10-22 Process for preparing a substituted allylamine derivative and the salts thereof

Publications (2)

Publication Number Publication Date
DE69909848D1 true DE69909848D1 (en) 2003-08-28
DE69909848T2 DE69909848T2 (en) 2004-04-15

Family

ID=10991303

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909848T Expired - Lifetime DE69909848T2 (en) 1999-10-22 1999-10-22 METHOD FOR PRODUCING SUBSTITUTED ALLYLAMINE DERIVATIVES AND THEIR SALTS

Country Status (14)

Country Link
US (1) US6770786B1 (en)
EP (1) EP1222160B1 (en)
AT (1) ATE245624T1 (en)
AU (1) AU6360499A (en)
CZ (1) CZ301429B6 (en)
DE (1) DE69909848T2 (en)
DK (1) DK1222160T3 (en)
ES (1) ES2203190T3 (en)
PL (1) PL190207B1 (en)
PT (1) PT1222160E (en)
RU (1) RU2217414C1 (en)
SI (1) SI1222160T1 (en)
SK (1) SK286804B6 (en)
WO (1) WO2001028976A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0103046D0 (en) 2001-02-07 2001-03-21 Novartis Ag Organic Compounds
KR100459275B1 (en) * 2001-12-28 2004-12-03 주식회사유한양행 A PROCESS FOR THE PREPARATION OF TERBINAFINE OR HCl SALT THEREOF
GB0320312D0 (en) 2003-08-29 2003-10-01 Novartis Ag Purification process
GB0503942D0 (en) * 2005-02-25 2005-04-06 Novartis Ag Purification process
KR101140865B1 (en) * 2004-02-17 2012-05-03 에스케이바이오팜 주식회사 Continuous Process for the preparation of 1-Chloro-6,6-dimethyl-2-hepten-4-yne
WO2005110968A1 (en) * 2004-05-14 2005-11-24 Hydex Chemicals Pvt Ltd. An improved process for the preparation of terbinafine hydrochloride
ES2245596B1 (en) * 2004-06-10 2007-07-01 Ercros Industrial, S.A. Production of terbinaphin hydrochlorate (TH) comprises reaction of chlorinated and methylamine derivatives with reflux of isopropanol increasing performance
US20060004230A1 (en) * 2004-06-30 2006-01-05 Joseph Kaspi Process for the preparation of terbinafine and salts thereof
US20060084826A1 (en) * 2004-08-30 2006-04-20 Glenmark Pharmaceuticals Limited Process for the preparation of naphthylmethylamine derivatives
WO2007044273A1 (en) * 2005-10-04 2007-04-19 Dr. Reddy's Laboratories Ltd. Process for preparing terbinafine
WO2007052089A1 (en) * 2005-11-02 2007-05-10 Aurobindo Pharma Ltd A process for the purification of 1-halo-6,6-dimethyl-hept-2-ene-4-yne
WO2007096904A2 (en) * 2006-02-23 2007-08-30 Manne Satyanarayana Reddy Improved process for the preparation of terbinafine hydrochloride and novel crystalline form of terbinafine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU611014B2 (en) 1988-05-06 1991-05-30 Sumitomo Chemical Company, Limited A pyrazole compound and its production and use
CH678527A5 (en) * 1989-06-22 1991-09-30 Sandoz Ag Trans(E)-N-(1-naphthyl:methyl)-heptenyl-amine prepn. - by simultaneously converting crude mixt. contg. cis and trans isomers to salt and precipitating trans isomer

Also Published As

Publication number Publication date
CZ20021268A3 (en) 2002-07-17
DE69909848T2 (en) 2004-04-15
CZ301429B6 (en) 2010-02-24
SK286804B6 (en) 2009-05-07
ATE245624T1 (en) 2003-08-15
EP1222160A1 (en) 2002-07-17
PT1222160E (en) 2003-12-31
DK1222160T3 (en) 2003-11-17
PL190207B1 (en) 2005-11-30
SI1222160T1 (en) 2003-12-31
EP1222160B1 (en) 2003-07-23
PL354929A1 (en) 2004-03-22
US6770786B1 (en) 2004-08-03
WO2001028976A1 (en) 2001-04-26
AU6360499A (en) 2001-04-30
RU2217414C1 (en) 2003-11-27
SK4682002A3 (en) 2002-07-02
ES2203190T3 (en) 2004-04-01

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