DE69835215D1 - Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen - Google Patents

Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen

Info

Publication number
DE69835215D1
DE69835215D1 DE69835215T DE69835215T DE69835215D1 DE 69835215 D1 DE69835215 D1 DE 69835215D1 DE 69835215 T DE69835215 T DE 69835215T DE 69835215 T DE69835215 T DE 69835215T DE 69835215 D1 DE69835215 D1 DE 69835215D1
Authority
DE
Germany
Prior art keywords
inhibitors
isomerases
phosphothreoninpecific
phosphoserin
pepidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69835215T
Other languages
English (en)
Other versions
DE69835215T2 (de
Inventor
Ping Lu
C Cantley
Michael Yaffee
Gunter Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Beth Israel Deaconess Medical Center Inc
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Beth Israel Deaconess Medical Center Inc
Beth Israel Hospital Association
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV, Beth Israel Deaconess Medical Center Inc, Beth Israel Hospital Association filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Application granted granted Critical
Publication of DE69835215D1 publication Critical patent/DE69835215D1/de
Publication of DE69835215T2 publication Critical patent/DE69835215T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69835215T 1997-09-08 1998-09-04 Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen Expired - Fee Related DE69835215T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5816497P 1997-09-08 1997-09-08
US58164P 1997-09-08
US988842 1997-12-11
US08/988,842 US6462173B1 (en) 1997-09-08 1997-12-11 Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases
PCT/US1998/018862 WO1999012962A1 (en) 1997-09-08 1998-09-04 Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases

Publications (2)

Publication Number Publication Date
DE69835215D1 true DE69835215D1 (de) 2006-08-24
DE69835215T2 DE69835215T2 (de) 2007-05-31

Family

ID=26737312

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69835215T Expired - Fee Related DE69835215T2 (de) 1997-09-08 1998-09-04 Inhibitoren von phosphoserin- und phosphothreoninspezifischen isomerasen

Country Status (8)

Country Link
US (2) US6462173B1 (de)
EP (1) EP1012178B1 (de)
JP (1) JP2001515917A (de)
AT (1) ATE332919T1 (de)
AU (1) AU751271B2 (de)
CA (1) CA2303462A1 (de)
DE (1) DE69835215T2 (de)
WO (1) WO1999012962A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972697A (en) 1995-11-13 1999-10-26 The Salk Institute For Biological Studies NIMA interacting proteins
US7125677B2 (en) 1995-11-13 2006-10-24 The Salk Institute For Biological Studies NIMA interacting proteins
US20010016346A1 (en) * 1998-06-09 2001-08-23 Joseph P. Noel Pedtidyl-prolyl cis-trans isomerase inhibitors and uses therefore
US6495376B1 (en) 1999-02-18 2002-12-17 Beth Israel Deaconess Medical Center Methods and compositions for regulating protein-protein interactions
US20020025521A1 (en) 1999-11-29 2002-02-28 Lu Kun Ping Pin1 as a marker for abnormal cell growth
JP2004532390A (ja) * 2001-02-09 2004-10-21 ピンテックス ファーマシューティカルズ，インク． 前立腺癌のマーカとしてのｐｉｎ１
WO2003018618A2 (de) * 2001-08-20 2003-03-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Katalyse der cis-trans isomerisierung von sekundären-amid peptidverbindungen
US7109230B2 (en) * 2002-01-07 2006-09-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
AU2003213698A1 (en) * 2002-03-01 2003-09-16 Pintex Pharmaceuticals, Inc. Methods for designing specific inhibitors for pin1 proline isomerase and pin1-related molecules
AU2003258982A1 (en) * 2002-06-28 2004-01-19 Pintex Pharmaceuticals, Inc. Methods of inhibiting pin1-associated states using a fredericamycin a compound
WO2004016751A2 (en) * 2002-08-15 2004-02-26 Beth Israel Deaconess Medical Center Methods of treating neurodegenerative diseases
US20040176277A1 (en) * 2003-03-03 2004-09-09 Pintex Pharmaceuticals, Inc. Methods of treating Pin1 associated disorders
US20080058276A1 (en) * 2006-01-13 2008-03-06 Cornell Research Foundation, Inc. Alzheimer's disease therapeutics based on pin-1 catalyzed conformational changes in phosphorylated amyloid precursor protein
US8771693B2 (en) * 2009-10-27 2014-07-08 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US10485780B2 (en) 2011-03-14 2019-11-26 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the treatment of proliferative disorders
US10487114B2 (en) 2011-04-27 2019-11-26 Beth Israel Deaconess Medical Center, Inc. Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof
US9439884B2 (en) 2011-05-26 2016-09-13 Beth Israel Deaconess Medical Center, Inc. Methods for the treatment of immune disorders
US9730941B2 (en) 2012-06-07 2017-08-15 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the inhibition of Pin1
US9688747B2 (en) 2013-03-15 2017-06-27 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US10351914B2 (en) 2014-07-17 2019-07-16 Beth Israel Deaconess Medical Center, Inc. Biomarkers for Pin1-associated disorders
WO2016011268A1 (en) 2014-07-17 2016-01-21 Beth Israel Deaconess Medical Center, Inc. Atra for modulating pin1 activity and stability
US10548864B2 (en) 2015-03-12 2020-02-04 Beth Israel Deaconess Medical Center, Inc. Enhanced ATRA-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444682A (en) * 1982-11-04 1984-04-24 The Salk Institute For Biological Studies Method of sulfation
US4490364A (en) * 1983-05-20 1984-12-25 The Salk Institute For Biological Studies CCK Agonists II
US4584377A (en) 1983-08-18 1986-04-22 Ss Pharmaceutical Co., Ltd. Novel Fredericamycin A derivatives
US4612132A (en) 1984-07-20 1986-09-16 Chevron Research Company Modified succinimides
US5013722A (en) * 1986-06-06 1991-05-07 Hoffmann-Laroche Inc. Cholecystokinin analogs for controlling appetite
US4673678A (en) 1986-07-25 1987-06-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble derivatives of fredericamycin A
JPH03146477A (ja) * 1989-10-31 1991-06-21 Asahi Glass Co Ltd セラミックス接着用組成物およびセラミックスの接着方法
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
US5166208A (en) 1991-10-09 1992-11-24 Boston College Fredericamycin A derivatives
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5532167A (en) 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5972697A (en) 1995-11-13 1999-10-26 The Salk Institute For Biological Studies NIMA interacting proteins

Also Published As

Publication number Publication date
EP1012178B1 (de) 2006-07-12
EP1012178A1 (de) 2000-06-28
AU2703299A (en) 1999-05-24
US20030109423A1 (en) 2003-06-12
AU751271B2 (en) 2002-08-08
CA2303462A1 (en) 1999-03-18
WO1999012962A8 (en) 1999-07-01
DE69835215T2 (de) 2007-05-31
WO1999012962A1 (en) 1999-03-18
ATE332919T1 (de) 2006-08-15
US6462173B1 (en) 2002-10-08
JP2001515917A (ja) 2001-09-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee