DE69834923D1 - Hochgradig lipophile camptothecin-derivate - Google Patents

Hochgradig lipophile camptothecin-derivate

Info

Publication number
DE69834923D1
DE69834923D1 DE69834923T DE69834923T DE69834923D1 DE 69834923 D1 DE69834923 D1 DE 69834923D1 DE 69834923 T DE69834923 T DE 69834923T DE 69834923 T DE69834923 T DE 69834923T DE 69834923 D1 DE69834923 D1 DE 69834923D1
Authority
DE
Germany
Prior art keywords
camptothecin
hochgradig
lipophile
derivate
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69834923T
Other languages
English (en)
Other versions
DE69834923T2 (de
Inventor
H Hausheer
Kochat Haridas
P Seetharamulu
G Reddy
Shijie Yao
N Petluru
Dhanabalan Murali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioNumerik Pharmaceuticals Inc
Original Assignee
BioNumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNumerik Pharmaceuticals Inc filed Critical BioNumerik Pharmaceuticals Inc
Publication of DE69834923D1 publication Critical patent/DE69834923D1/de
Application granted granted Critical
Publication of DE69834923T2 publication Critical patent/DE69834923T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Silicon Polymers (AREA)
  • Saccharide Compounds (AREA)
DE69834923T 1997-02-14 1998-02-11 Hochgradig lipophile camptothecin-derivate Expired - Lifetime DE69834923T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3714897P 1997-02-14 1997-02-14
US37148P 1997-02-14
PCT/US1998/002375 WO1998035940A1 (en) 1997-02-14 1998-02-11 Highly lipophilic camptothecin derivatives

Publications (2)

Publication Number Publication Date
DE69834923D1 true DE69834923D1 (en) 2006-07-27
DE69834923T2 DE69834923T2 (de) 2006-10-19

Family

ID=21892705

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69834923T Expired - Lifetime DE69834923T2 (de) 1997-02-14 1998-02-11 Hochgradig lipophile camptothecin-derivate

Country Status (10)

Country Link
EP (1) EP1017675B1 (de)
JP (2) JP4311765B2 (de)
AT (1) ATE329903T1 (de)
AU (1) AU6272598A (de)
CA (1) CA2280905C (de)
DE (1) DE69834923T2 (de)
DK (1) DK1017675T3 (de)
ES (1) ES2262223T3 (de)
PT (1) PT1017675E (de)
WO (1) WO1998035940A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150343A (en) 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6136978A (en) * 1993-06-30 2000-10-24 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6743917B2 (en) 1993-06-30 2004-06-01 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
WO1998035940A1 (en) * 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US6057303A (en) * 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
AU4822500A (en) * 1999-05-04 2000-11-17 Bionumerik Pharmaceuticals, Inc. Novel highly lipophilic camptothecin analogs
US6350756B1 (en) * 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
IL162058A0 (en) 2001-11-30 2005-11-20 Chugai Pharmaceutical Co Ltd Hexacyclic compounds
AU2003243380A1 (en) 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
EP1393719A1 (de) * 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-Carboxylat Formulierungen
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
WO2005060871A1 (en) * 2003-12-17 2005-07-07 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
CA2563502A1 (en) 2004-04-09 2005-10-20 Chugai Seiyaku Kabushiki Kaisha Novel water-soluble prodrug
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
US7875602B2 (en) 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
TW200731990A (en) 2005-12-16 2007-09-01 Sonus Pharma Inc Lipophilic anticancer drug compounds, compositions, and related methods
RU2441008C2 (ru) * 2006-08-11 2012-01-27 Дзе Кристус Стелин Фаундейшн Фор Кэнсер Рисерч Способы получения сложных эфиров камптотецинов
EP2586463B1 (de) 2010-06-11 2016-08-17 Japan Science and Technology Agency Pharmazeutische multimere partikel und herstellungsverfahren dafür
US9556192B2 (en) 2012-10-30 2017-01-31 Nerviano Medical Sciences S.R.L. Functionalized 9-bromo-camptothecin derivatives
FR3029637B1 (fr) 2014-12-05 2018-01-05 Universite De Strasbourg Microdispositif de detection de composes organiques volatils et methode de detection d'au moins un compose organique volatil compris dans un echantillon gazeux
JP7332576B2 (ja) 2018-09-14 2023-08-23 ダウ シリコーンズ コーポレーション 感圧性接着剤ならびにその調製および使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
US5446047A (en) * 1992-07-23 1995-08-29 Sloan-Kettering Institute For Cancer Research Camptothecin analogues
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
WO1998035940A1 (en) * 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Also Published As

Publication number Publication date
AU6272598A (en) 1998-09-08
DK1017675T3 (da) 2006-10-16
CA2280905A1 (en) 1998-08-20
CA2280905C (en) 2006-08-29
ATE329903T1 (de) 2006-07-15
ES2262223T3 (es) 2006-11-16
PT1017675E (pt) 2006-09-29
JP5264561B2 (ja) 2013-08-14
JP2009149680A (ja) 2009-07-09
EP1017675A1 (de) 2000-07-12
DE69834923T2 (de) 2006-10-19
WO1998035940A1 (en) 1998-08-20
EP1017675A4 (de) 2001-08-22
JP4311765B2 (ja) 2009-08-12
EP1017675B1 (de) 2006-06-14
JP2001511807A (ja) 2001-08-14

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Legal Events

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8364 No opposition during term of opposition