DE69834809D1 - Verfahren zur gewinnung von seltenen zellen aus blutprodukten - Google Patents
Verfahren zur gewinnung von seltenen zellen aus blutproduktenInfo
- Publication number
- DE69834809D1 DE69834809D1 DE69834809T DE69834809T DE69834809D1 DE 69834809 D1 DE69834809 D1 DE 69834809D1 DE 69834809 T DE69834809 T DE 69834809T DE 69834809 T DE69834809 T DE 69834809T DE 69834809 D1 DE69834809 D1 DE 69834809D1
- Authority
- DE
- Germany
- Prior art keywords
- rare cells
- cells
- porous medium
- blood products
- elution fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000010836 blood and blood product Substances 0.000 title abstract 3
- 229940125691 blood product Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 5
- 238000010828 elution Methods 0.000 abstract 3
- 239000012530 fluid Substances 0.000 abstract 3
- 210000004443 dendritic cell Anatomy 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 210000005087 mononuclear cell Anatomy 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4320097P | 1997-04-08 | 1997-04-08 | |
US43200P | 1997-04-08 | ||
US6411197P | 1997-11-03 | 1997-11-03 | |
US64111P | 1997-11-03 | ||
US6419297P | 1997-11-04 | 1997-11-04 | |
US64192P | 1997-11-04 | ||
PCT/US1998/006643 WO1998045413A1 (en) | 1997-04-08 | 1998-04-03 | Method of harvesting rare cells from blood products |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69834809D1 true DE69834809D1 (de) | 2006-07-20 |
DE69834809T2 DE69834809T2 (de) | 2007-05-16 |
Family
ID=27366293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69834809T Expired - Lifetime DE69834809T2 (de) | 1997-04-08 | 1998-04-03 | Verfahren zur gewinnung von seltenen zellen aus blutprodukten |
Country Status (8)
Country | Link |
---|---|
US (2) | US6544751B1 (de) |
EP (2) | EP0973873B1 (de) |
JP (1) | JP4187275B2 (de) |
AT (1) | ATE329012T1 (de) |
AU (1) | AU6795498A (de) |
CA (1) | CA2286156C (de) |
DE (1) | DE69834809T2 (de) |
WO (1) | WO1998045413A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040224300A1 (en) * | 1997-01-24 | 2004-11-11 | Shuji Terashima | Method for separating nucleated cells |
DE69834809T2 (de) * | 1997-04-08 | 2007-05-16 | Pall Corp. | Verfahren zur gewinnung von seltenen zellen aus blutprodukten |
US7745106B2 (en) * | 1997-06-24 | 2010-06-29 | Cascade Medical Enterprises, Llc | Methods and devices for separating liquid components |
US6979307B2 (en) * | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
MXPA03009258A (es) * | 2001-04-10 | 2004-11-12 | Bioergonomics Inc | Composiciones y metodos para separacion celular. |
US7074440B2 (en) * | 2002-05-01 | 2006-07-11 | Rulin Xiu | Compositions and methods for body weight loss |
PT3173141T (pt) * | 2002-06-19 | 2019-11-25 | Northwest Biotherapeutics Inc | Dispositivos e métodos de filtração de fluxo tangencial para o enriquecimento de leucócitos |
US7291450B2 (en) * | 2003-03-28 | 2007-11-06 | Smith & Nephew, Inc. | Preparation of a cell concentrate from a physiological solution |
US20050208501A1 (en) | 2004-03-16 | 2005-09-22 | Ambion, Inc. | Process and reagents for extraction of RNA from fractionated blood leukocytes |
US20060234210A1 (en) * | 2004-04-14 | 2006-10-19 | Affinergy, Inc. | Filtration device and method for removing selected materials from biological fluids |
WO2006029270A1 (en) * | 2004-09-07 | 2006-03-16 | Smith & Nephew, Inc. | Methods and devices for sterile field transfer |
WO2006058153A1 (en) * | 2004-11-23 | 2006-06-01 | Smith & Nephew, Inc. | Composite mixer |
AU2005316276B2 (en) * | 2004-12-16 | 2010-12-09 | Idexx Laboratories, Inc. | Apparatus and method to elute microorganisms from a filter |
EP1846163A2 (de) * | 2005-01-13 | 2007-10-24 | Micronics, Inc. | Mikrofluidische vorrichtung zur detektion seltener zellen |
US8979770B2 (en) * | 2006-02-24 | 2015-03-17 | Merck Sharp & Dohme Corp. | Extraction and diagnostic fluid devices, systems and methods of use |
US7598089B2 (en) * | 2006-04-19 | 2009-10-06 | Bioe, Inc. | Methods and compositions for separating cells |
US7713688B2 (en) * | 2007-01-26 | 2010-05-11 | Bioe, Llc | Methods and compositions for depleting specific cell populations from blood tissues |
JP5243456B2 (ja) | 2007-03-02 | 2013-07-24 | スミス アンド ネフュー ピーエルシー | 生物学的サンプルろ過中の超音波、逆流洗浄、およびフィルタ運動によるフィルタ洗浄装置および方法 |
US8158405B2 (en) * | 2008-06-30 | 2012-04-17 | General Electric Company | Process for concentrating and processing fluid samples |
US8546127B2 (en) * | 2008-06-30 | 2013-10-01 | General Electric Company | Bacteria/RNA extraction device |
WO2010012002A1 (en) * | 2008-07-25 | 2010-01-28 | Saryna Medical Corporation | Methods and systems for genetic analysis of fetal nucleated red blood cells |
US20100151438A1 (en) * | 2008-12-12 | 2010-06-17 | General Electric Company | Methods and kits for enhancing sedimentation and recovery of cells in a sample |
US8961787B2 (en) | 2008-12-01 | 2015-02-24 | General Electric Company | Systems and methods for processing complex biological materials |
US20100210989A1 (en) | 2008-12-23 | 2010-08-19 | Janet Lesley Macpherson | Processing blood |
WO2011001936A1 (ja) | 2009-06-30 | 2011-01-06 | 株式会社カネカ | 血液成分の分離システム、分離材 |
US9034280B2 (en) * | 2009-12-16 | 2015-05-19 | General Electric Corporation | High-throughput methods and systems for processing biological materials |
EP2363501A1 (de) * | 2010-03-02 | 2011-09-07 | Universitätsklinikum Hamburg-Eppendorf | Verfahren zur Isolierung von Zielzellen |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
US20130323712A1 (en) | 2010-11-25 | 2013-12-05 | Kaneka Corporation | Method and material for separating leukocytes or mononuclear cells |
JP2012120458A (ja) * | 2010-12-06 | 2012-06-28 | Kaneka Corp | 細胞の分離器具。 |
US20130143195A1 (en) | 2011-12-05 | 2013-06-06 | Pall Corporation | Leukocyte purification |
US9421317B2 (en) | 2012-06-08 | 2016-08-23 | Pall Corporation | Cell harvesting device and system |
US9427512B2 (en) | 2012-06-08 | 2016-08-30 | Pall Corporation | Filter device |
GB201306810D0 (en) | 2013-04-15 | 2013-05-29 | Cells4Life Group Llp | Methods of cell separation |
CA3007631A1 (en) | 2015-12-11 | 2017-06-15 | Research Institute At Nationwide Children's Hospital | Optimized patient specific non-linear tissue engineered vascular grafts |
US10940248B2 (en) * | 2016-12-19 | 2021-03-09 | Fenwal, Inc. | Systems and methods for recovering white blood cells from a leukoreduction filter |
US20230258663A9 (en) | 2019-05-02 | 2023-08-17 | Kellbenx Incorporated | Filtration-based methods for preparing fetal nucleated red blood cells (nrbcs) for diagnostic testing |
CN111454902B (zh) * | 2020-04-08 | 2022-12-02 | 郭华 | 血液分离富集白细胞、干细胞和/或病原体的方法及装置 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070243A (en) * | 1976-08-30 | 1978-01-24 | University Of Illinois Foundation | Method for distinguishing subpopulations in a population of morphologically indistinguishable cells |
GB2018151B (en) | 1978-03-06 | 1982-12-08 | Asahi Chemical Ind | Seperation of leukocytes from leukocyte-containing suspension by filtration |
US4255267A (en) * | 1979-11-02 | 1981-03-10 | E. I. Du Pont De Nemours And Company | Separation and recovery of granulocytes from blood using adherence on an expandable bed of a polymeric material |
JPS57145662A (en) | 1981-03-02 | 1982-09-08 | Asahi Chemical Ind | Filter, method and apparatus for sampling white corpuscle component |
US4500509A (en) * | 1981-03-11 | 1985-02-19 | Lawrence Kass | Metachromatic dye sorption and fluorescent light emmisive means for differential determination of developmental stages of neutrophilic granulocytic cells and other leukocytes |
US4448879A (en) * | 1981-03-26 | 1984-05-15 | Hooper Trading Company | High yield process for in vitro production of serum-free and mitogen-free interleukin-2 |
US4645738A (en) * | 1983-09-30 | 1987-02-24 | Memorial Sloan-Kettering Institute Cancer Center | Method for differential diagnosis of T cell leukemias using monoclonal antibodies |
US4965204A (en) | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
JPS63127765A (ja) | 1986-11-17 | 1988-05-31 | テルモ株式会社 | 濾過器 |
US4923620A (en) | 1987-10-20 | 1990-05-08 | Pall Corporation | Device for depletion of the leukocyte content of blood and blood components |
GB2231282B (en) | 1989-05-09 | 1993-08-04 | Pall Corp | Device and method for depletion of the leucocyte content of blood and blood components |
EP0406485A1 (de) | 1989-07-03 | 1991-01-09 | NPBI Nederlands Produktielaboratorium voor Bloedtransfusieapparatuur en Infusievloeistoffen B.V. | Verfahren zur Abscheidung von Leukocyten aus einer Leukocyten enthaltenden Suspension und Filter zur Verwendung dazu |
US5258126A (en) | 1989-09-12 | 1993-11-02 | Pall Corporation | Method for obtaining platelets |
US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
GB9026538D0 (en) | 1990-12-06 | 1991-01-23 | Knight Scient Ltd | Filtration arrangement |
FR2695563B1 (fr) * | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
IL104670A (en) * | 1993-02-09 | 1998-04-05 | Travenol Lab Israel Ltd | Leukocyte removal method and filter unit for same |
GB9307321D0 (en) * | 1993-04-07 | 1993-06-02 | Knight Scient Ltd | Method of separating particles from a filter |
AU6773994A (en) * | 1993-04-23 | 1994-11-21 | Cellpro, Incorporated | Methods for enriching fetal progenitor cells from maternal blood |
DE69417549T2 (de) | 1993-12-22 | 1999-11-25 | Baxter International Inc., Deerfield | Verfahren zur schätzung des durchschnittlichen faserdurchmessers von unterschiedlichen filtrationsmitteln |
US5432054A (en) * | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
US6001647A (en) * | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
US5972627A (en) * | 1994-06-15 | 1999-10-26 | Systemix, Inc. | Method of purifying a population of cells enriched for dendritic and/or lymphoid progenitors and populations of cells obtained thereby |
GB9413029D0 (en) * | 1994-06-29 | 1994-08-17 | Common Services Agency | Stem cell immobilisation |
US5789148A (en) * | 1994-08-31 | 1998-08-04 | Dendreon Corporation | Cell separation composition |
DE69513188T2 (de) | 1994-08-31 | 2000-07-06 | Dendreon Corp., Seattle | Vorrichtung und verfahren zur trennung von zellen |
JPH08104643A (ja) | 1994-10-05 | 1996-04-23 | Asahi Medical Co Ltd | 赤血球除去方法 |
US5647985A (en) * | 1994-10-17 | 1997-07-15 | Baxter International Inc. | Whole blood leukodepletion and platelet filter |
US5662813A (en) * | 1994-10-21 | 1997-09-02 | Bioseparations, Inc. | Method for separation of nucleated fetal erythrocytes from maternal blood samples |
US5677136A (en) * | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
US5965457A (en) * | 1995-06-06 | 1999-10-12 | Magnani; John L. | Methods of screening for a candidate compound able to bind to CD34+ cells |
US6015554A (en) * | 1995-06-07 | 2000-01-18 | Systemix, Inc. | Method of reconstituting human lymphoid and dendritic cells |
WO1996040875A1 (en) * | 1995-06-07 | 1996-12-19 | Novartis Ag | Methods for obtaining compositions enriched for hematopoietic stem cells and antibodies for use therein |
US5891443A (en) * | 1995-07-03 | 1999-04-06 | The United States Of America As Represented By The Secretary Of Agriculture | Method to produce granulocyte colony stimulating factor from immortalized avian T lymphocytes to produce immortalized cells |
CA2239729C (en) | 1995-12-11 | 2006-10-31 | Dendreon Corporation | Cell separation composition, kit and method |
GB9603249D0 (en) * | 1996-02-16 | 1996-04-17 | Univ Nottingham | Foetal cell analysis |
JP3322595B2 (ja) * | 1996-03-28 | 2002-09-09 | テルモ株式会社 | フィルター装置および生体微細組織の分離・回収方法 |
WO1998005795A1 (en) * | 1996-08-02 | 1998-02-12 | The Center For Blood Research, Inc. | Enrichment of dendritic cells from blood |
EP0987325B1 (de) * | 1997-01-24 | 2011-05-11 | Asahi Kasei Kuraray Medical Co., Ltd. | Methode zur zelltrennung |
DE69834809T2 (de) * | 1997-04-08 | 2007-05-16 | Pall Corp. | Verfahren zur gewinnung von seltenen zellen aus blutprodukten |
US6120474A (en) | 1997-12-15 | 2000-09-19 | Nissho Corporation | Blood component-recovering apparatus and a method for recovering blood components using the same |
US5989441A (en) * | 1997-12-22 | 1999-11-23 | Interferon Science, Inc. | Recovery of functional human leukocytes from recycled filters |
JP2001161352A (ja) | 1999-12-03 | 2001-06-19 | Asahi Medical Co Ltd | 生体組織再生用細胞の分離方法、生体組織再生用細胞及び生体組織再生用細胞分離装置 |
-
1998
- 1998-04-03 DE DE69834809T patent/DE69834809T2/de not_active Expired - Lifetime
- 1998-04-03 WO PCT/US1998/006643 patent/WO1998045413A1/en active IP Right Grant
- 1998-04-03 US US09/402,158 patent/US6544751B1/en not_active Expired - Lifetime
- 1998-04-03 EP EP98913392A patent/EP0973873B1/de not_active Expired - Lifetime
- 1998-04-03 AU AU67954/98A patent/AU6795498A/en not_active Abandoned
- 1998-04-03 AT AT98913392T patent/ATE329012T1/de active
- 1998-04-03 CA CA2286156A patent/CA2286156C/en not_active Expired - Lifetime
- 1998-04-03 EP EP06075344A patent/EP1690930A1/de not_active Withdrawn
- 1998-04-03 JP JP54293298A patent/JP4187275B2/ja not_active Expired - Lifetime
-
2003
- 2003-02-11 US US10/361,586 patent/US20030134417A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2001518792A (ja) | 2001-10-16 |
EP0973873A1 (de) | 2000-01-26 |
CA2286156C (en) | 2013-03-19 |
JP4187275B2 (ja) | 2008-11-26 |
US6544751B1 (en) | 2003-04-08 |
CA2286156A1 (en) | 1998-10-15 |
WO1998045413A1 (en) | 1998-10-15 |
US20030134417A1 (en) | 2003-07-17 |
EP0973873B1 (de) | 2006-06-07 |
EP1690930A1 (de) | 2006-08-16 |
ATE329012T1 (de) | 2006-06-15 |
DE69834809T2 (de) | 2007-05-16 |
AU6795498A (en) | 1998-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |