DE69829605D1 - Chondroitinase enthaltende Zusammensetzungen - Google Patents

Chondroitinase enthaltende Zusammensetzungen

Info

Publication number
DE69829605D1
DE69829605D1 DE69829605T DE69829605T DE69829605D1 DE 69829605 D1 DE69829605 D1 DE 69829605D1 DE 69829605 T DE69829605 T DE 69829605T DE 69829605 T DE69829605 T DE 69829605T DE 69829605 D1 DE69829605 D1 DE 69829605D1
Authority
DE
Germany
Prior art keywords
chondroitinase
containing compositions
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69829605T
Other languages
English (en)
Other versions
DE69829605T2 (de
Inventor
Shin-Ichi Ishikawa
Mine Higuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seikagaku Corp
Original Assignee
Seikagaku Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Corp filed Critical Seikagaku Corp
Application granted granted Critical
Publication of DE69829605D1 publication Critical patent/DE69829605D1/de
Publication of DE69829605T2 publication Critical patent/DE69829605T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
DE69829605T 1997-05-02 1998-04-30 Chondroitinase enthaltende Zusammensetzungen Expired - Lifetime DE69829605T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12778597 1997-05-02
JP12778597 1997-05-02

Publications (2)

Publication Number Publication Date
DE69829605D1 true DE69829605D1 (de) 2005-05-12
DE69829605T2 DE69829605T2 (de) 2006-02-09

Family

ID=14968630

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69829605T Expired - Lifetime DE69829605T2 (de) 1997-05-02 1998-04-30 Chondroitinase enthaltende Zusammensetzungen

Country Status (3)

Country Link
US (1) US6007810A (de)
EP (1) EP0875253B1 (de)
DE (1) DE69829605T2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063378A (en) * 1997-08-22 2000-05-16 Seikagaku Corporation Therapeutic agent for herniated intervertebral disc
EP1182204B1 (de) * 1999-06-03 2004-04-07 Eisai Co., Ltd. Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion
US6723349B1 (en) * 1999-10-12 2004-04-20 Emory University Polyoxometalate materials, metal-containing materials, and methods of use thereof
WO2002038170A2 (en) * 2000-11-07 2002-05-16 Chiron Corporation Stabilized inteferon compositions
IL160188A0 (en) 2001-08-13 2004-07-25 Univ Florida Materials and methods to promote repair of nerve tissue
GB0205022D0 (en) * 2002-03-04 2002-04-17 Univ Cambridge Tech Materials and methods for the treatment of cns damage
WO2004108069A2 (en) * 2002-05-04 2004-12-16 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
US6962699B2 (en) 2002-06-03 2005-11-08 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase B
US20060153827A1 (en) * 2002-08-15 2006-07-13 Gruskin Elliott A Chimeric protein
EP2460881B1 (de) * 2003-05-16 2017-05-03 Acorda Therapeutics, Inc. Proteoglycan-abbauende Mutanten zur Behandlung des ZNS
ATE524067T1 (de) * 2003-05-16 2011-09-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur behandlung von zns-schäden
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
EP1737954A2 (de) * 2004-03-10 2007-01-03 The Massachusetts Institute Of Technology Rekombinante chondroitinase abc i und verwendungen davon
WO2005112986A2 (en) * 2004-05-18 2005-12-01 Acorda Therapeutics, Inc. Purifying chondroitinase and stable formulations thereof
JP5189985B2 (ja) * 2005-09-26 2013-04-24 アコーダ セラピューティクス、インク． コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
CN101129381B (zh) * 2006-08-25 2012-02-01 天津和美生物技术有限公司 含β-内酰胺类抗生素和离子螯合剂的抗生素复方
ES2473610T3 (es) 2006-10-10 2014-07-07 Acorda Therapeutics, Inc. Composiciones y métodos de uso de mutantes de condroitinasa ABCI
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
CA2821244C (en) 2010-12-13 2016-08-09 Seikagaku Corporation Chondroitinase abc for disk herniation
WO2019167983A1 (ja) * 2018-02-28 2019-09-06 生化学工業株式会社 医薬組成物、包装体及びその製造方法
CN111443050A (zh) * 2019-01-16 2020-07-24 烟台东诚药业集团股份有限公司 一种糖胺聚糖制剂中溶出曲线检测的新方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1067253A (en) * 1965-02-15 1967-05-03 Biorex Laboratories Ltd Process for the preparation of enzymes
US4696816A (en) * 1985-11-07 1987-09-29 Brown Mark D Method for treating intervertebral disc displacement with enzymes
JP3140797B2 (ja) * 1991-04-26 2001-03-05 生化学工業株式会社 安定化コンドロイチナーゼａｂｃ、その保存方法及び治療剤
WO1993000807A1 (en) * 1991-07-03 1993-01-21 Cryolife, Inc. Method for stabilization of biomaterials
US5496718A (en) * 1992-06-26 1996-03-05 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Chondroitinase ABC isolated from proteus vulgaris ATCC 6896
JPH0698769A (ja) * 1992-09-22 1994-04-12 Maruha Corp コンドロイチナーゼ及びその遺伝子
JPH0767642A (ja) * 1993-09-03 1995-03-14 Seikagaku Kogyo Co Ltd 酵素組成物
US5741692A (en) * 1994-04-22 1998-04-21 American Cyanamid Company Protein vulgaris chondroitinase II

Also Published As

Publication number Publication date
EP0875253A3 (de) 2000-11-22
EP0875253B1 (de) 2005-04-06
DE69829605T2 (de) 2006-02-09
US6007810A (en) 1999-12-28
EP0875253A2 (de) 1998-11-04

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Legal Events

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