DE69823211D1 - Unmodifizierte hämoglobine und deren verwendung - Google Patents
Unmodifizierte hämoglobine und deren verwendungInfo
- Publication number
- DE69823211D1 DE69823211D1 DE69823211T DE69823211T DE69823211D1 DE 69823211 D1 DE69823211 D1 DE 69823211D1 DE 69823211 T DE69823211 T DE 69823211T DE 69823211 T DE69823211 T DE 69823211T DE 69823211 D1 DE69823211 D1 DE 69823211D1
- Authority
- DE
- Germany
- Prior art keywords
- sno
- groups
- methods
- nitrosated
- tissues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6445—Haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/796,164 US6884773B1 (en) | 1995-09-15 | 1997-02-06 | Modified hemoglobins, including nitrosylhemoglobins, and uses thereof |
US796164 | 1997-02-06 | ||
US08/874,992 US6911427B1 (en) | 1995-09-15 | 1997-06-12 | No-modified hemoglobins and uses therefore |
US874992 | 1997-06-12 | ||
PCT/US1998/002383 WO1998034955A1 (en) | 1997-02-06 | 1998-02-05 | No-modified hemoglobins and uses therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69823211D1 true DE69823211D1 (de) | 2004-05-19 |
DE69823211T2 DE69823211T2 (de) | 2004-08-26 |
Family
ID=27121701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69823211T Expired - Fee Related DE69823211T2 (de) | 1997-02-06 | 1998-02-05 | No-modifizierte Hämoglobine und Verwendung dafür |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1015490B1 (de) |
JP (1) | JP2002513400A (de) |
AT (1) | ATE264343T1 (de) |
AU (1) | AU6150298A (de) |
CA (1) | CA2278784A1 (de) |
DE (1) | DE69823211T2 (de) |
WO (1) | WO1998034955A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6916471B2 (en) | 1995-09-15 | 2005-07-12 | Duke University | Red blood cells loaded with S-nitrosothiol and uses therefor |
US6087087A (en) * | 1997-07-03 | 2000-07-11 | Takashi Yonetani | Treatment of hemoglobin with nitric oxide |
JP2000230000A (ja) * | 1999-02-08 | 2000-08-22 | Hokkaido Univ | 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体 |
CA2266174A1 (en) * | 1999-03-18 | 2000-09-18 | Hemosol Inc. | Hemoglobin-antioxidant conjugates |
CA2680378C (en) * | 1999-08-02 | 2013-09-24 | Duke University | Method for determining physiological effects of hemoglobin |
US6314956B1 (en) * | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
US6627602B2 (en) * | 2001-11-13 | 2003-09-30 | Duke University | Preventing desensitization of receptors |
EP1514103A4 (de) * | 2002-05-29 | 2006-05-24 | Univ Duke | Messung von stickstoffmonoxid in blutgasen und darauf beruhende behandlungen |
US8075922B2 (en) | 2002-12-12 | 2011-12-13 | Montana State University-Bozeman | Method of co-infusing a deoxygenated hemoglobin containing blood substitute and inorganic nitrite |
DE102004043279A1 (de) * | 2004-09-08 | 2006-03-23 | Theo Woike | Verfahren und Vorrichtung zum biologischen, medizinischen und pharmazeutischen Gebrauch des Nitrosylmoleküls NO durch optische Anregung von metastabilen Zuständen in Nitrosylkomplexen |
US8735354B2 (en) * | 2008-11-07 | 2014-05-27 | Uab Research Foundation | Endothelium mimicking nanomatrix |
US7989593B1 (en) * | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
WO2013070592A1 (en) * | 2011-11-07 | 2013-05-16 | The General Hospital Corporation | Treatment of red blood cells |
EP3444615B1 (de) * | 2017-08-15 | 2021-09-08 | Freiberg Instruments GmbH | Verfahren und zusammensetzungen zur diagnostischen beurteilung und therapeutischen korrektur des no-haem-signalwegs bei tieren und menschen |
CN111912802B (zh) * | 2020-08-25 | 2023-05-26 | 潍坊市生态环境局寿光分局 | 一种分光光度法检测亚硝酸盐氮的方法 |
IL310677A (en) * | 2021-08-13 | 2024-04-01 | Univ Hospitals Cleveland Medical Center | Noninvasive measurement of endogenous S-nitrosothiols |
WO2024119059A1 (en) * | 2022-12-01 | 2024-06-06 | University Of Maryland, Baltimore | Measurement of reactive oxygen species to assess red blood cell quality |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0676964B1 (de) * | 1991-11-14 | 2001-01-24 | Brigham And Women's Hospital | Die nitrosylierung von enzym-sh gruppen als eine therapeutische massnahme |
TW381022B (en) * | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
AU5368296A (en) * | 1995-03-24 | 1996-10-16 | Brigham And Women's Hospital | Nitrosylated blood substitutes |
US6197745B1 (en) * | 1995-09-15 | 2001-03-06 | Duke University | Methods for producing nitrosated hemoglobins and therapeutic uses therefor |
-
1998
- 1998-02-05 AU AU61502/98A patent/AU6150298A/en not_active Abandoned
- 1998-02-05 AT AT98906222T patent/ATE264343T1/de not_active IP Right Cessation
- 1998-02-05 CA CA002278784A patent/CA2278784A1/en not_active Abandoned
- 1998-02-05 EP EP98906222A patent/EP1015490B1/de not_active Expired - Lifetime
- 1998-02-05 DE DE69823211T patent/DE69823211T2/de not_active Expired - Fee Related
- 1998-02-05 WO PCT/US1998/002383 patent/WO1998034955A1/en active IP Right Grant
- 1998-02-05 JP JP53494398A patent/JP2002513400A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1015490B1 (de) | 2004-04-14 |
CA2278784A1 (en) | 1998-08-13 |
ATE264343T1 (de) | 2004-04-15 |
DE69823211T2 (de) | 2004-08-26 |
WO1998034955A1 (en) | 1998-08-13 |
AU6150298A (en) | 1998-08-26 |
EP1015490A1 (de) | 2000-07-05 |
JP2002513400A (ja) | 2002-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |