ATE361359T1 - Funktion und aktivität des viralen proteins r (vpr) - Google Patents
Funktion und aktivität des viralen proteins r (vpr)Info
- Publication number
- ATE361359T1 ATE361359T1 AT94909839T AT94909839T ATE361359T1 AT E361359 T1 ATE361359 T1 AT E361359T1 AT 94909839 T AT94909839 T AT 94909839T AT 94909839 T AT94909839 T AT 94909839T AT E361359 T1 ATE361359 T1 AT E361359T1
- Authority
- AT
- Austria
- Prior art keywords
- vpr
- activity
- disclosed
- methods
- identifying compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/019,601 US5874225A (en) | 1993-02-19 | 1993-02-19 | Identification of compounds that modulate HIV-1 vpr protein activity |
| US08/167,608 US6838236B1 (en) | 1993-02-19 | 1993-12-15 | VPR function and activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361359T1 true ATE361359T1 (de) | 2007-05-15 |
Family
ID=26692390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94909839T ATE361359T1 (de) | 1993-02-19 | 1994-02-22 | Funktion und aktivität des viralen proteins r (vpr) |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20030207252A1 (de) |
| EP (1) | EP0689586B8 (de) |
| AT (1) | ATE361359T1 (de) |
| AU (1) | AU6252494A (de) |
| CA (1) | CA2155017C (de) |
| DE (1) | DE69434961T2 (de) |
| DK (1) | DK0689586T3 (de) |
| ES (1) | ES2286818T3 (de) |
| IL (1) | IL108707A (de) |
| MX (1) | MXPA94001321A (de) |
| WO (1) | WO1994019456A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2042093C (en) * | 1990-05-09 | 2002-12-24 | Gyula Hadlaczky | Cell line carrying an excess of mammalian centromeres |
| JPH09511395A (ja) * | 1994-03-25 | 1997-11-18 | バイオモレキュラー リサーチ インスティテュート リミティド | ＨＩＶ の Ｖｐｒ及び Ｖｐｘ蛋白質 |
| US5861161A (en) | 1994-09-07 | 1999-01-19 | Universite De Montreal | Chimeric proteins comprising a Vpr/Vpx virion incorporation domain for targeting into HIV-1 or HIV-2 virions |
| US5763190A (en) | 1994-09-21 | 1998-06-09 | The Trustees Of The University Of Pennsylvania | Methods for the identification of compounds capable of inducing the nuclear translocation of a receptor complex comprising the glucocoticoid receptor type II and viral protein R interacting protein |
| US5639619A (en) * | 1994-10-13 | 1997-06-17 | Regents Of The University Of California | Screening assay for anti-HIV drugs using the Vpr gene |
| US6087486A (en) * | 1996-01-29 | 2000-07-11 | The Trustees Of The University Of Pennsylvania | Nucleotide sequences encoding vpr receptor protein |
| US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6077697A (en) | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| WO1998035234A1 (en) * | 1997-02-11 | 1998-08-13 | The Regents Of The University Of California | Identifying agents for treating lentiviral infection |
| US6818627B1 (en) | 1997-08-14 | 2004-11-16 | The Trustees Of The University Of Pennsylvania | Functional fragments of HIV-1 Vpr protein and methods of using the same |
| DE19908766C2 (de) * | 1999-02-19 | 2001-02-15 | Ulrich Schubert | Verwendung synthetischer Vpr-Peptide des Humanen Immundefizienzvirus Typ 1 (HIV-1) zur Entwicklung von therapeutischen und diagnostischen Reagenzien |
| US6984486B1 (en) | 1999-02-19 | 2006-01-10 | J. David Gladstone Institutes | Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof |
| US6664040B2 (en) | 2000-05-23 | 2003-12-16 | The Regents Of The University Of California | Compositions and methods for delivery of a molecule into a cell |
| DK1397520T3 (da) * | 2001-05-25 | 2006-03-27 | Univ Pennsylvania | HIV-1 Vpr-interaktioner med mitokondriel apoptoseinducerende faktor samt fremgangsmåder til anvendelse heraf |
| AU2002329176A1 (en) | 2001-05-25 | 2002-12-23 | The Trustees Of The University Of Pennsylvania | Targeted particles and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4808536A (en) * | 1986-02-27 | 1989-02-28 | Centocor, Inc. | Immunochemical method for detection of antibody against HTLV-III core protein based upon recombinant HTLV-III gag gene encoded protein |
| DE3885355T2 (de) * | 1987-05-29 | 1994-06-01 | Shuzo Matsushita | Monoklonale Antikörper. |
| US5001230A (en) * | 1988-02-18 | 1991-03-19 | Schering Corporation | T cell activation markers |
| WO1990015875A1 (en) * | 1989-06-02 | 1990-12-27 | Dana Farber Cancer Institute | Protein having a transactivating property, vectors expressing this protein, cell lines, and uses thereof |
-
1994
- 1994-02-18 IL IL10870794A patent/IL108707A/en not_active IP Right Cessation
- 1994-02-21 MX MXPA94001321A patent/MXPA94001321A/es not_active Application Discontinuation
- 1994-02-22 AT AT94909839T patent/ATE361359T1/de not_active IP Right Cessation
- 1994-02-22 ES ES94909839T patent/ES2286818T3/es not_active Expired - Lifetime
- 1994-02-22 EP EP94909839A patent/EP0689586B8/de not_active Expired - Lifetime
- 1994-02-22 WO PCT/US1994/002191 patent/WO1994019456A1/en active IP Right Grant
- 1994-02-22 CA CA002155017A patent/CA2155017C/en not_active Expired - Fee Related
- 1994-02-22 DE DE69434961T patent/DE69434961T2/de not_active Expired - Fee Related
- 1994-02-22 AU AU62524/94A patent/AU6252494A/en not_active Abandoned
- 1994-02-22 DK DK94909839T patent/DK0689586T3/da active
-
2001
- 2001-08-22 US US09/935,100 patent/US20030207252A1/en not_active Abandoned
-
2008
- 2008-01-09 US US11/971,792 patent/US20100183622A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69434961D1 (de) | 2007-06-14 |
| EP0689586B1 (de) | 2007-05-02 |
| CA2155017C (en) | 2009-06-09 |
| EP0689586A4 (de) | 1997-12-29 |
| DK0689586T3 (da) | 2007-08-06 |
| EP0689586A1 (de) | 1996-01-03 |
| ES2286818T3 (es) | 2007-12-01 |
| IL108707A0 (en) | 1994-05-30 |
| AU6252494A (en) | 1994-09-14 |
| DE69434961T2 (de) | 2008-01-17 |
| IL108707A (en) | 1999-06-20 |
| MXPA94001321A (es) | 2003-10-29 |
| US20100183622A1 (en) | 2010-07-22 |
| EP0689586B8 (de) | 2008-01-02 |
| WO1994019456A1 (en) | 1994-09-01 |
| CA2155017A1 (en) | 1994-09-01 |
| US20030207252A1 (en) | 2003-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |