DE69820288D1 - Phenanthrolin-derivate - Google Patents

Phenanthrolin-derivate

Info

Publication number
DE69820288D1
DE69820288D1 DE69820288T DE69820288T DE69820288D1 DE 69820288 D1 DE69820288 D1 DE 69820288D1 DE 69820288 T DE69820288 T DE 69820288T DE 69820288 T DE69820288 T DE 69820288T DE 69820288 D1 DE69820288 D1 DE 69820288D1
Authority
DE
Germany
Prior art keywords
hydrogen
alkoxycarbonyl
alkyl
alkylcarbamoyl
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820288T
Other languages
English (en)
Other versions
DE69820288T2 (de
Inventor
Philip Neil Edwards
Michael Stewart Large
James Hales
R Martin
Xinfan Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Fibrogen Inc
Original Assignee
Syngenta Ltd
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/957,450 external-priority patent/US5916898A/en
Application filed by Syngenta Ltd, Fibrogen Inc filed Critical Syngenta Ltd
Application granted granted Critical
Publication of DE69820288D1 publication Critical patent/DE69820288D1/de
Publication of DE69820288T2 publication Critical patent/DE69820288T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69820288T 1997-10-24 1998-10-26 Phenanthrolin-derivate Expired - Lifetime DE69820288T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/957,450 US5916898A (en) 1997-10-24 1997-10-24 Phenanthroline derivatives
US17788898A 1998-10-23 1998-10-23
PCT/US1998/022704 WO1999021860A1 (en) 1997-10-24 1998-10-26 Phenanthroline derivatives

Publications (2)

Publication Number Publication Date
DE69820288D1 true DE69820288D1 (de) 2004-01-15
DE69820288T2 DE69820288T2 (de) 2004-10-21

Family

ID=26873748

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820288T Expired - Lifetime DE69820288T2 (de) 1997-10-24 1998-10-26 Phenanthrolin-derivate

Country Status (8)

Country Link
EP (1) EP1027351B1 (de)
JP (1) JP2003522093A (de)
AT (1) ATE255581T1 (de)
AU (1) AU754607B2 (de)
CA (1) CA2308551C (de)
DE (1) DE69820288T2 (de)
HK (1) HK1030214A1 (de)
WO (1) WO1999021860A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153503A1 (en) 2001-12-06 2003-08-14 Klaus Stephen J. Methods of increasing endogenous erythropoietin (EPO)
US8318703B2 (en) 2001-12-06 2012-11-27 Fibrogen, Inc. Methods for improving kidney function
EP2295060B1 (de) 2001-12-06 2018-10-31 Fibrogen, Inc. Behandlung ischämischer oder hypoxischer Zustände
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
WO2005007192A2 (en) * 2003-06-06 2005-01-27 Fibrogen, Inc. Cytoprotection through the use of hif hydroxylase inhibitors
KR20080028918A (ko) 2005-06-15 2008-04-02 피브로겐, 인크. 암의 치료를 위한 화합물과 방법
US7625927B2 (en) 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
CN104974187A (zh) * 2014-04-10 2015-10-14 吉林省博创药业有限公司 菲罗啉类衍生物及其制备方法和应用
EP3937941A4 (de) * 2019-03-11 2023-07-19 The Regents of the University of California Hydrogels und verfahren zur verwendung davon

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5512031B2 (de) * 1972-10-31 1980-03-29
JPS5653678A (en) * 1980-06-25 1981-05-13 Taisho Pharmaceut Co Ltd Preparation of 1,10-phenanthroilnes
DE3703963A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3703959A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3707429A1 (de) * 1987-03-07 1988-09-15 Hoechst Ag Substituierte pyridin-2,4-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Also Published As

Publication number Publication date
AU754607B2 (en) 2002-11-21
HK1030214A1 (en) 2001-04-27
JP2003522093A (ja) 2003-07-22
AU2702799A (en) 1999-05-17
WO1999021860B1 (en) 1999-08-05
CA2308551A1 (en) 1999-05-06
WO1999021860A1 (en) 1999-05-06
ATE255581T1 (de) 2003-12-15
CA2308551C (en) 2010-02-16
DE69820288T2 (de) 2004-10-21
EP1027351A1 (de) 2000-08-16
EP1027351B1 (de) 2003-12-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition