DE69819505D1 - Mit smad wechselwirkende polypeptide und verwendungen davon - Google Patents
Mit smad wechselwirkende polypeptide und verwendungen davonInfo
- Publication number
- DE69819505D1 DE69819505D1 DE69819505T DE69819505T DE69819505D1 DE 69819505 D1 DE69819505 D1 DE 69819505D1 DE 69819505 T DE69819505 T DE 69819505T DE 69819505 T DE69819505 T DE 69819505T DE 69819505 D1 DE69819505 D1 DE 69819505D1
- Authority
- DE
- Germany
- Prior art keywords
- smad
- sub
- domain
- sip1
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102100025744 Mothers against decapentaplegic homolog 1 Human genes 0.000 abstract 2
- 101700032040 SMAD1 Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 108700014236 Drosophila zfh1 Proteins 0.000 abstract 1
- 102100039556 Galectin-4 Human genes 0.000 abstract 1
- 102000009331 Homeodomain Proteins Human genes 0.000 abstract 1
- 108010048671 Homeodomain Proteins Proteins 0.000 abstract 1
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 abstract 1
- 102100025751 Mothers against decapentaplegic homolog 2 Human genes 0.000 abstract 1
- 101710143123 Mothers against decapentaplegic homolog 2 Proteins 0.000 abstract 1
- 102100030610 Mothers against decapentaplegic homolog 5 Human genes 0.000 abstract 1
- 101710143113 Mothers against decapentaplegic homolog 5 Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 102100033130 T-box transcription factor T Human genes 0.000 abstract 1
- 101710086566 T-box transcription factor T Proteins 0.000 abstract 1
- 101710185494 Zinc finger protein Proteins 0.000 abstract 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 210000001161 mammalian embryo Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000010396 two-hybrid screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201645 | 1997-06-02 | ||
| EP97201645 | 1997-06-02 | ||
| PCT/EP1998/003193 WO1998055512A2 (en) | 1997-06-02 | 1998-05-28 | Smad-interacting polypeptides and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69819505D1 true DE69819505D1 (de) | 2003-12-11 |
| DE69819505T2 DE69819505T2 (de) | 2004-10-14 |
Family
ID=8228387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69819505T Expired - Lifetime DE69819505T2 (de) | 1997-06-02 | 1998-05-28 | Mit smad wechselwirkende polypeptide und verwendungen davon |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6313280B1 (de) |
| EP (1) | EP0994945B1 (de) |
| JP (1) | JP4108768B2 (de) |
| AT (1) | ATE253636T1 (de) |
| AU (1) | AU8623798A (de) |
| CA (1) | CA2291754C (de) |
| DE (1) | DE69819505T2 (de) |
| WO (1) | WO1998055512A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU772452B2 (en) * | 1999-06-25 | 2004-04-29 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Nucleic acid binding of multi-zinc finger transcription factors |
| US6673570B1 (en) | 1999-09-20 | 2004-01-06 | Ludwig Institute For Cancer Research | Smad associating polypeptides |
| EP1228204A2 (de) * | 1999-09-20 | 2002-08-07 | Ludwig Institute For Cancer Research | Smad-assoziierende peptide |
| FR2807437B1 (fr) * | 2000-04-07 | 2004-08-27 | Inst Nat Sante Rech Med | Gene codant pour l'erbin, proteine qui interagit avec le recepteur erbb2/her-2, et utilisations diagnostiques et therapeutiques |
| WO2003045990A2 (en) * | 2001-11-26 | 2003-06-05 | Hybrigenics | Protein-protein interactions involving transforming growth factor beta signalling |
| US7361635B2 (en) | 2002-08-29 | 2008-04-22 | Sangamo Biosciences, Inc. | Simultaneous modulation of multiple genes |
| KR100471605B1 (ko) * | 2002-10-04 | 2005-03-10 | 재단법인서울대학교산학협력재단 | 군소 투-하이브리드 시스템 |
| WO2005044980A2 (en) * | 2003-08-13 | 2005-05-19 | The Trustees Of Columbia University In The City Of New York | Zap protein and related compositions and methods |
| ES2526705T3 (es) | 2005-10-25 | 2015-01-14 | The Johns Hopkins University | Métodos y composiciones para el tratamiento de síndrome de Marfan y trastornos asociados |
| US8454952B2 (en) | 2006-03-13 | 2013-06-04 | The Johns Hopkins University | Augmentation of endothelial thromboresistance |
| CA2823154A1 (en) | 2010-12-27 | 2012-07-05 | Lsip, Llc | Ips cells and method for generating same |
| US20150044178A1 (en) | 2011-12-28 | 2015-02-12 | Kyoto Prefectural Public University Corporation | Normalization of culture of corneal endothelial cells |
| CN102809596B (zh) * | 2012-08-21 | 2014-07-09 | 辉源生物科技（上海）有限公司 | 分离培养新生鼠皮层神经细胞记录t型钙通道电流的方法 |
| JPWO2015064768A1 (ja) | 2013-10-31 | 2017-03-09 | 京都府公立大学法人 | 角膜内皮の小胞体細胞死関連疾患治療薬 |
| US10882903B2 (en) | 2015-05-18 | 2021-01-05 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and compositions for treating an alphavirus infection |
-
1998
- 1998-05-28 JP JP50144699A patent/JP4108768B2/ja not_active Expired - Fee Related
- 1998-05-28 CA CA002291754A patent/CA2291754C/en not_active Expired - Fee Related
- 1998-05-28 AT AT98937426T patent/ATE253636T1/de not_active IP Right Cessation
- 1998-05-28 WO PCT/EP1998/003193 patent/WO1998055512A2/en active IP Right Grant
- 1998-05-28 AU AU86237/98A patent/AU8623798A/en not_active Abandoned
- 1998-05-28 EP EP98937426A patent/EP0994945B1/de not_active Expired - Lifetime
- 1998-05-28 DE DE69819505T patent/DE69819505T2/de not_active Expired - Lifetime
-
1999
- 1999-11-24 US US09/449,285 patent/US6313280B1/en not_active Expired - Fee Related
-
2001
- 2001-09-26 US US09/964,238 patent/US6884779B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6884779B2 (en) | 2005-04-26 |
| AU8623798A (en) | 1998-12-21 |
| US20020035246A1 (en) | 2002-03-21 |
| CA2291754C (en) | 2009-11-17 |
| CA2291754A1 (en) | 1998-12-10 |
| EP0994945B1 (de) | 2003-11-05 |
| WO1998055512A3 (en) | 1999-03-11 |
| EP0994945A2 (de) | 2000-04-26 |
| JP2002505577A (ja) | 2002-02-19 |
| JP4108768B2 (ja) | 2008-06-25 |
| DE69819505T2 (de) | 2004-10-14 |
| ATE253636T1 (de) | 2003-11-15 |
| WO1998055512A2 (en) | 1998-12-10 |
| US6313280B1 (en) | 2001-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69819505D1 (de) | Mit smad wechselwirkende polypeptide und verwendungen davon | |
| Mann | The specificity of homeotic gene function | |
| Frank et al. | Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils. | |
| Jimenez et al. | Bromocontryphan: post-translational bromination of tryptophan | |
| ATE301188T1 (de) | Reprimiertes trans-aktivatorsystem zur charakterisierung von protein-protein interaktionen | |
| NO962991L (no) | Zink-finger-proteinderivater og fremgangsmåter derav | |
| RS50728B (sr) | Nukleinske kiseline i polipeptidi novog receptora | |
| Novello et al. | TsTX-IV, a short chain four-disulfide-bridged neurotoxin from Tityus serrulatus venom which acts on Ca2+-activated K+ channels | |
| ATE301714T1 (de) | Insulinartigen wachstumsfaktor bindendes protein -3 variante | |
| ATE291627T1 (de) | Chimäre des g-proteins | |
| Viganò et al. | Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context | |
| CY1111763T1 (el) | ΑΝΤΙΣΩΜΑΤΑ ΕΝΑΝΤΙΟΝ ΤΗΣ ΠΡΩΤΕΪΝΗΣ p51 | |
| EP1612222A3 (de) | G-Protein Rezeptoren für Geruchs- und Pheromonmolekülen | |
| Le Douarin et al. | TIF I α: chromatin-specific mediator for the ligand-dependent activation function AF-2 of nuclear receptors? | |
| Brauer et al. | The primary structure of protein S3 from the small ribosomal subunit of Escherichia coli | |
| DE69925116D1 (de) | Neue, physiologisch aktive peptide und ihre verwendung. | |
| Renner et al. | Alterations in titer and distribution of high mobility group proteins during embryonic development of Drosophila melanogaster | |
| KR940008700A (ko) | 사람형 모노클로날 항펩티드 항체 및 이것을 코드하는 dna | |
| ATE393224T1 (de) | Nukleinsäuresequenzen von hyperplasien und tumoren der schilddrüse | |
| ATE410513T1 (de) | 'patched-2' protein aus wirbeltieren | |
| WO1999052941B1 (en) | Polypeptide domains capable of binding rho protein and their use in assays | |
| Lecomte et al. | Maurotoxin and the Kv1. 1 channel: voltage‐dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31–Cys34 | |
| Bianchi et al. | PROTEIN COMPLEXES’98 | |
| DE60026569D1 (de) | Zusammensetzungen auf der basis von gfr-alpha-4 und deren anwendungen | |
| WO2003044159A9 (en) | Zinc finger proteins, polynucleotides encoding same and antibodies thereto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |