DE69819192D1 - Neue cyanoaziridine zur behandlung von krebs - Google Patents

Neue cyanoaziridine zur behandlung von krebs

Info

Publication number
DE69819192D1
DE69819192D1 DE69819192T DE69819192T DE69819192D1 DE 69819192 D1 DE69819192 D1 DE 69819192D1 DE 69819192 T DE69819192 T DE 69819192T DE 69819192 T DE69819192 T DE 69819192T DE 69819192 D1 DE69819192 D1 DE 69819192D1
Authority
DE
Germany
Prior art keywords
aryl
lower alkyl
cyanoaziridine
new
treating cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69819192T
Other languages
English (en)
Other versions
DE69819192T2 (de
Inventor
A Remers
M Hersh
T Dorr
Bhashyam Iyengar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amplimed Inc
Original Assignee
Amplimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amplimed Inc filed Critical Amplimed Inc
Application granted granted Critical
Publication of DE69819192D1 publication Critical patent/DE69819192D1/de
Publication of DE69819192T2 publication Critical patent/DE69819192T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69819192T 1997-06-27 1998-06-26 Neue cyanoaziridine zur behandlung von krebs Expired - Lifetime DE69819192T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5103797P 1997-06-27 1997-06-27
US51037 1997-06-27
PCT/US1998/013346 WO1999000120A1 (en) 1997-06-27 1998-06-26 Novel cyanoaziridines for treating cancer

Publications (2)

Publication Number Publication Date
DE69819192D1 true DE69819192D1 (de) 2003-11-27
DE69819192T2 DE69819192T2 (de) 2004-06-09

Family

ID=21968974

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69819192T Expired - Lifetime DE69819192T2 (de) 1997-06-27 1998-06-26 Neue cyanoaziridine zur behandlung von krebs

Country Status (8)

Country Link
US (1) US6297230B1 (de)
EP (1) EP1027041B1 (de)
AT (1) ATE252381T1 (de)
AU (1) AU8171498A (de)
CA (1) CA2294243C (de)
DE (1) DE69819192T2 (de)
ES (1) ES2210774T3 (de)
WO (1) WO1999000120A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041871A2 (en) * 2000-11-21 2002-05-30 Board Of Regents, The University Of Texas System Composition comprising an imexon or derivatives thereof and lipids
MXPA06006291A (es) * 2003-12-08 2006-08-23 Univ Arizona Composiciones anti-cancer sinergisticas.
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists
WO2008045686A2 (en) * 2006-10-12 2008-04-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Enantiomerically enriched iminopyrrolidone azirdine compositions
CN102531980B (zh) * 2011-12-02 2013-11-27 江苏远洋药业股份有限公司 一种dl-半胱氨酸的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2727550A1 (de) * 1977-06-18 1979-01-04 Boehringer Mannheim Gmbh Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)- 2-cyanaziridine sowie verfahren zur herstellung derselben
CA1092606A (en) * 1976-10-05 1980-12-30 Herbert Berger 1-(n-acylcarbamoyl)-2-cyano-aziridines and the preparation thereof
DE2906603A1 (de) 1979-02-21 1980-09-04 Boehringer Mannheim Gmbh N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Also Published As

Publication number Publication date
DE69819192T2 (de) 2004-06-09
US6297230B1 (en) 2001-10-02
ES2210774T3 (es) 2004-07-01
AU8171498A (en) 1999-01-19
ATE252381T1 (de) 2003-11-15
WO1999000120A1 (en) 1999-01-07
EP1027041B1 (de) 2003-10-22
EP1027041A1 (de) 2000-08-16
CA2294243C (en) 2008-12-30
EP1027041A4 (de) 2001-06-13
CA2294243A1 (en) 1999-01-07

Similar Documents

Publication Publication Date Title
NL350077I1 (nl) Cyprosulfamide
AR000119A1 (es) Compuesto de piridacinona composición fungicida que la comprende y método para controlar hongos fitopatogenos con el mismo
ATE321452T1 (de) Tetracycline verbindungen zur behandlung von spezifischen krebsarten
MX9304571A (es) Compuestos fanilicos ligados a un arilo o heteroarilo mediante un radical alifatico o un atomo heterogeneo que contiene un grupo eslabonador.
CO5150173A1 (es) Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
CO5690638A2 (es) Nuevos compuestos triciclicos utiles para el tratamiento de desordenes inflamatorios y alergicos; proceso para su preparacion y composiciones farmaceuticas que los contienen
HUP9802859A2 (hu) Acil-amino-szalicilsav-amid-származékok és alkalmazásuk peszticidként
ES308421A1 (es) Procedimiento de preparacion de compuestos pesticidas.
ES444523A1 (es) Un procedimiento para preparar nuevos derivados de benzo- triazol.
ES384015A1 (es) Procedimiento para la preparacion de un medio regulador delcrecimiento de plantas.
SE8104435L (sv) 7-substituerade bensopyraner jemte sett for deras framstellning
DE69819192D1 (de) Neue cyanoaziridine zur behandlung von krebs
PE20031038A1 (es) Compuestos triciclicos como inhibidores de la farnesil proteina transferasa
ES393496A1 (es) Procedimiento de preparacion de nuevos derivados de la 2-pi-rrolidinonas.
MX9301045A (es) Procedimiento para preparar antagonistas receptores de fibrinogeno.
ATE217870T1 (de) Verfahren zur herstell ung von baccatin iii- analogen, verbindungen mit neuen funktionellen gruppen an c2 und c4
DE69910568D1 (de) Furopyridinderivate und ihre therapeutische verwendung
CU34216A (es) Derivados de dibenzofurano
CO6241191A2 (es) Compuestos de amida heterociclicos y su uso
ES2053629T3 (es) Resinas de bismaleinimida.
SE7713314L (sv) Artropodrepellenter
EA199900910A1 (ru) Профилактика рака молочной железы селективными модуляторами рецепторов эстрогена
DK182181A (da) Antihypertensivt virksomme lactamer og fremgangsmaade til fremstilling heraf
DE60043228D1 (de) Herstellungsverfahren von 2-cyanopyridinen
ES378034A1 (es) Un metodo para la produccion de un compuesto herbicida.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition