DE69817565D1 - Bioreduktive konjugate zur gezielten wirkstoffzufuhr - Google Patents

Bioreduktive konjugate zur gezielten wirkstoffzufuhr

Info

Publication number
DE69817565D1
DE69817565D1 DE69817565T DE69817565T DE69817565D1 DE 69817565 D1 DE69817565 D1 DE 69817565D1 DE 69817565 T DE69817565 T DE 69817565T DE 69817565 T DE69817565 T DE 69817565T DE 69817565 D1 DE69817565 D1 DE 69817565D1
Authority
DE
Germany
Prior art keywords
bioreductive
active substance
disease
linked
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69817565T
Other languages
English (en)
Other versions
DE69817565T2 (de
Inventor
David Blake
Declan Naughton
Ged Adams
Ian Stratford
Christopher Morris
Mohammed Jaffar
Matthew Naylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Manchester Manchester Gb, University of
Original Assignee
Victoria University of Manchester
University of Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9703002.7A external-priority patent/GB9703002D0/en
Priority claimed from GBGB9712090.1A external-priority patent/GB9712090D0/en
Application filed by Victoria University of Manchester, University of Manchester filed Critical Victoria University of Manchester
Application granted granted Critical
Publication of DE69817565D1 publication Critical patent/DE69817565D1/de
Publication of DE69817565T2 publication Critical patent/DE69817565T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/559—Redox delivery systems, e.g. dihydropyridine pyridinium salt redox systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69817565T 1997-02-11 1998-02-13 Bioreduktive konjugate zur gezielten wirkstoffzufuhr Expired - Lifetime DE69817565T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9703002.7A GB9703002D0 (en) 1997-02-11 1997-02-11 Bioreductively activated drug targeting
GB9703002 1997-02-13
GBGB9712090.1A GB9712090D0 (en) 1997-06-10 1997-06-10 Bioreductively activated drug targeting
GB9712090 1997-06-10
PCT/GB1998/000461 WO1998035701A1 (en) 1997-02-11 1998-02-13 Drug targeting

Publications (2)

Publication Number Publication Date
DE69817565D1 true DE69817565D1 (de) 2003-10-02
DE69817565T2 DE69817565T2 (de) 2004-06-24

Family

ID=26310992

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69817565T Expired - Lifetime DE69817565T2 (de) 1997-02-11 1998-02-13 Bioreduktive konjugate zur gezielten wirkstoffzufuhr

Country Status (8)

Country Link
US (1) US7829555B1 (de)
EP (1) EP0988057B1 (de)
JP (1) JP2001512425A (de)
AT (1) ATE247984T1 (de)
CA (1) CA2280874A1 (de)
DE (1) DE69817565T2 (de)
ES (1) ES2206891T3 (de)
WO (1) WO1998035701A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808562D0 (en) * 1998-04-22 1998-06-24 Univ Cardiff Treatment of stroke and other ischaemic conditions
AU5429699A (en) * 1998-08-19 2000-03-14 Theramark Limited Drug targeting
DE602004020187D1 (de) * 2003-02-20 2009-05-07 Constant Res & Dev Ltd Prozess zur Herstellung einer Dexamethason enthaltenden Formulierung zur oralen Anwendung
GB0517957D0 (en) 2005-09-03 2005-10-12 Morvus Technology Ltd Method of combating infection
GB0526552D0 (en) 2005-12-29 2006-02-08 Morvus Technology Ltd New use
GB2442202A (en) 2006-09-30 2008-04-02 Morvus Technology Ltd Vermin poison
CN109758587B (zh) * 2019-02-25 2022-04-05 华东师范大学 一种具有乏氧靶向性的多价配体药物偶联物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2131020B (en) 1982-11-25 1986-10-01 Gerald Edward Adams Improvements relating to compounds useful in radiotherapy or chemotherapy
US5086068A (en) 1988-02-26 1992-02-04 Alberta Cancer Board Immunochemical detection of hypoxia in normal and tumor tissue
GB9113487D0 (en) * 1991-06-21 1991-08-07 Amersham Int Plc Agents for hypoxic cells
GB9114426D0 (en) 1991-07-03 1991-08-21 Nat Res Dev Compounds useful for treating tumours ii
GB9114336D0 (en) 1991-07-03 1991-08-21 Nat Res Dev Anti-tumour compounds ii
IT1251472B (it) 1991-09-12 1995-05-15 Boehringer Mannheim Italia Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
GB9219566D0 (en) 1992-09-16 1992-10-28 Adams Gerald E Novel bioreductive agents
GB9219565D0 (en) 1992-09-16 1992-10-28 Adams Gerald E Novel bioreductive compounds
IL105244A (en) 1993-03-31 2003-07-31 Dpharm Ltd Prodrugs with enhanced penetration into cells
CA2136803A1 (en) * 1993-12-22 1995-06-23 Kazumi Ogata Steroid derivatives
GB9404400D0 (en) 1994-03-07 1994-04-20 Wood Pauline J Potentiation of bioreductive agents
WO1996025147A1 (en) * 1995-02-14 1996-08-22 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering liposome-loadable drugs
AU1166097A (en) 1995-12-21 1997-07-17 British Technology Group Limited Indoloquinone derivatives as bioreductive agents

Also Published As

Publication number Publication date
CA2280874A1 (en) 1998-08-20
DE69817565T2 (de) 2004-06-24
EP0988057B1 (de) 2003-08-27
EP0988057A1 (de) 2000-03-29
JP2001512425A (ja) 2001-08-21
WO1998035701A1 (en) 1998-08-20
ES2206891T3 (es) 2004-05-16
ATE247984T1 (de) 2003-09-15
US7829555B1 (en) 2010-11-09

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: THE UNIVERSITY OF MANCHESTER, MANCHESTER, GB

8328 Change in the person/name/address of the agent

Representative=s name: PATENTANWAELTE ZELLENTIN & PARTNER GBR, 81667 MUENCHEN