DE69815298D1 - Teilchen mit polyaldehyd-dextran-überzug, die verkleinerte matrixeffekte aufweisen - Google Patents

Teilchen mit polyaldehyd-dextran-überzug, die verkleinerte matrixeffekte aufweisen

Info

Publication number
DE69815298D1
DE69815298D1 DE69815298T DE69815298T DE69815298D1 DE 69815298 D1 DE69815298 D1 DE 69815298D1 DE 69815298 T DE69815298 T DE 69815298T DE 69815298 T DE69815298 T DE 69815298T DE 69815298 D1 DE69815298 D1 DE 69815298D1
Authority
DE
Germany
Prior art keywords
polyaldehyde
coated particles
matrix effects
reduced matrix
dextran coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69815298T
Other languages
English (en)
Other versions
DE69815298T2 (de
Inventor
Chengrong Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Dade Behring Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Inc filed Critical Dade Behring Inc
Application granted granted Critical
Publication of DE69815298D1 publication Critical patent/DE69815298D1/de
Publication of DE69815298T2 publication Critical patent/DE69815298T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/86—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids the coating being pre-functionalised for attaching immunoreagents, e.g. aminodextran
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69815298T 1997-12-10 1998-12-08 Teilchen mit polyaldehyd-dextran-überzug, die verkleinerte matrixeffekte aufweisen Expired - Lifetime DE69815298T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/988,628 US6231982B1 (en) 1997-12-10 1997-12-10 Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
US988628 1997-12-10
PCT/US1998/026055 WO1999030160A1 (en) 1997-12-10 1998-12-08 Particles with polyaldehyde dextran coating having reduced matrix effects

Publications (2)

Publication Number Publication Date
DE69815298D1 true DE69815298D1 (de) 2003-07-10
DE69815298T2 DE69815298T2 (de) 2004-05-06

Family

ID=25534335

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69815298T Expired - Lifetime DE69815298T2 (de) 1997-12-10 1998-12-08 Teilchen mit polyaldehyd-dextran-überzug, die verkleinerte matrixeffekte aufweisen

Country Status (6)

Country Link
US (1) US6231982B1 (de)
EP (1) EP0961934B1 (de)
JP (1) JP2001513203A (de)
DE (1) DE69815298T2 (de)
ES (1) ES2200395T3 (de)
WO (1) WO1999030160A1 (de)

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US7179660B1 (en) 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
DE10152407A1 (de) * 2001-10-24 2003-05-08 Aesculap Ag & Co Kg Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten
DE10154016B4 (de) * 2001-10-26 2004-02-12 Berlin Heart Ag Magnetflüssigkeit und Verfahren zur ihrer Herstellung
US20070003975A1 (en) * 2003-05-02 2007-01-04 Canon Kabushiki Kaisha Structured construct and producing method therefor
CN104090097B (zh) * 2004-02-26 2017-04-12 康多尔生物技术有限公司 一种用作结合对的特异性结合反应培养基的水溶液
US8426126B2 (en) * 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
JP4873123B2 (ja) * 2005-11-28 2012-02-08 Ｊｓｒ株式会社 担体ポリマー粒子の製造方法
JP2006321932A (ja) * 2005-05-20 2006-11-30 Jsr Corp 担体ポリマー粒子およびその製造方法
US20090014682A1 (en) 2005-05-20 2009-01-15 Jsr Corporation Carrier Polymer Particle, Process for Producing the Same, Magnetic Particle for Specific Trapping, and Process for Producing the Same
TWI338779B (en) * 2005-07-21 2011-03-11 Academia Sinica Methods,compositions and systems for assaying at least one target analyte in a sample
EP1923703B1 (de) 2005-11-25 2015-05-06 FUJIFILM Corporation Verfahren zur Herstellung eines Biosensors mit einer dünnen und kovalent verbunden Polymerschicht
US9146233B2 (en) 2006-11-13 2015-09-29 Perkinelmer Health Sciences, Inc. Detecting molecular interactions by fluorescence resonance energy transfer on a solid-phase support
JP4897581B2 (ja) * 2007-06-12 2012-03-14 積水化学工業株式会社 親水化磁性体内包粒子の製造方法、親水化磁性体内包粒子及び免疫測定用粒子
US7910378B2 (en) 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
CN105675892A (zh) 2008-04-29 2016-06-15 赛凯米迪克斯股份有限公司 固相多分析物测试
US8084215B2 (en) 2008-04-29 2011-12-27 Psychemedics Corporation Non-proteolytic method for the determination of analytes in keratinized structures
US20100018674A1 (en) * 2008-07-22 2010-01-28 Donald John Enzinna Reservoir with moveable partition for quick recovery
TW201028692A (en) * 2009-01-23 2010-08-01 Nat Univ Tsing Hua Method for immobilizing protein
EP2230515B1 (de) 2009-03-16 2014-12-17 Agilent Technologies, Inc. Passivierung von Oberflächen nach Ligandenkupplung
GB0912584D0 (en) * 2009-07-20 2009-08-26 Ucl Business Plc Cyclosporin conjugates
US8394647B2 (en) 2011-02-17 2013-03-12 Siemens Healthcare Diagnostics Inc. Reducing non-covalently bound polysaccharide on supports
WO2014005065A1 (en) 2012-06-28 2014-01-03 Psychemedics Corporation Detection of analytes in hair wash samples
CN107430119A (zh) * 2015-03-10 2017-12-01 西门子医疗保健诊断公司 固体载体上的官能团的定量
WO2020068547A1 (en) 2018-09-25 2020-04-02 Siemens Healthcare Diagnostics Inc. Methods and compositions for removing biotin interference from assays using conjugated molecular traps
ES2972499T3 (es) * 2018-09-25 2024-06-13 Siemens Healthcare Diagnostics Inc Trampa molecular para eliminar las interferencias de biotina en los ensayos
EP3857227B1 (de) * 2018-09-25 2023-10-25 Siemens Healthcare Diagnostics Inc. Zusammensetzung zur entfernung von hapten-interferenz aus assays
EP4449119A1 (de) * 2021-12-17 2024-10-23 Siemens Healthcare Diagnostics Inc. Biotin-trap-kügelchen sowie verfahren zu ihrer herstellung und verwendung

Family Cites Families (18)

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US4534996A (en) 1981-03-30 1985-08-13 California Institute Of Technology Hybrid microspheres
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4861705A (en) 1983-01-31 1989-08-29 Yeda Research And Development Company, Ltd. Method for removing components of biological fluids
US5169773A (en) 1984-10-04 1992-12-08 Sandoz Ltd. Monoclonal antibodies to cyclosporins
US4719182A (en) 1985-03-18 1988-01-12 Eastman Kodak Company Fluorescent labels and labeled species and their use in analytical elements and determinations
US4661408A (en) 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
US5239057A (en) 1987-03-27 1993-08-24 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
JPH01503808A (ja) 1987-07-16 1989-12-21 イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー（インコーポレイテツド） 固定化された凝集剤を用いるアフイニテイ分離
AU4958590A (en) 1988-12-05 1990-07-10 Trustees Of Columbia University In The City Of New York, The Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof
US5151348A (en) 1988-12-23 1992-09-29 E. I. Du Pont De Nemours And Company Enzyme-linked immunoassay for measurement of cyclosporin a levels in whole blood samples
US5466609A (en) * 1990-10-31 1995-11-14 Coulter Corporation Biodegradable gelatin-aminodextran particle coatings of and processes for making same
US5639620A (en) * 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
US5169754A (en) 1990-10-31 1992-12-08 Coulter Corporation Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same
DE69133095T2 (de) 1990-11-20 2003-03-27 Dade Behring Marburg Gmbh Cyclosporin-Immunoassay
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
EP0665955B1 (de) 1992-10-15 2002-05-29 Coulter International Corporation Teilchen mit gelatine-aminodextran-umhüllungen und verfahren zu ihrer herstellung
EP0702793B1 (de) 1993-06-11 2003-08-27 Coulter International Corporation Anti-cd3-antikörper-aminodextran-konjugate zur induktion der t-zellen-aktivierung und vermehrung

Also Published As

Publication number Publication date
US6231982B1 (en) 2001-05-15
WO1999030160A1 (en) 1999-06-17
DE69815298T2 (de) 2004-05-06
EP0961934B1 (de) 2003-06-04
ES2200395T3 (es) 2004-03-01
EP0961934A1 (de) 1999-12-08
JP2001513203A (ja) 2001-08-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC., DEERFIELD, US

8328 Change in the person/name/address of the agent

Representative=s name: PLATE SCHWEITZER ZOUNEK PATENTANWAELTE, 65203 WIES