DE69802777D1 - 2,4-Bis(4-Amidino)phenylfurane als anti-pneumocystis carinii Mittel - Google Patents

2,4-Bis(4-Amidino)phenylfurane als anti-pneumocystis carinii Mittel

Info

Publication number
DE69802777D1
DE69802777D1 DE69802777T DE69802777T DE69802777D1 DE 69802777 D1 DE69802777 D1 DE 69802777D1 DE 69802777 T DE69802777 T DE 69802777T DE 69802777 T DE69802777 T DE 69802777T DE 69802777 D1 DE69802777 D1 DE 69802777D1
Authority
DE
Germany
Prior art keywords
phenylfurans
amidino
bis
pneumocystis carinii
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69802777T
Other languages
English (en)
Other versions
DE69802777T2 (de
Inventor
David W Boykin
Iris Francesconi
David W Wilson
Richard R Tidwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Georgia State University
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Georgia State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System, Georgia State University filed Critical University of North Carolina at Chapel Hill
Publication of DE69802777D1 publication Critical patent/DE69802777D1/de
Application granted granted Critical
Publication of DE69802777T2 publication Critical patent/DE69802777T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
DE69802777T 1998-02-27 1998-07-23 2,4-Bis(4-Amidino)phenylfurane als anti-pneumocystis carinii Mittel Expired - Fee Related DE69802777T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/032,586 US6008247A (en) 1998-02-27 1998-02-27 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents

Publications (2)

Publication Number Publication Date
DE69802777D1 true DE69802777D1 (de) 2002-01-17
DE69802777T2 DE69802777T2 (de) 2002-08-08

Family

ID=21865717

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69802777T Expired - Fee Related DE69802777T2 (de) 1998-02-27 1998-07-23 2,4-Bis(4-Amidino)phenylfurane als anti-pneumocystis carinii Mittel
DE69823707T Expired - Fee Related DE69823707T2 (de) 1998-02-27 1998-07-23 2,4 -Bis [(4-Amidino)phenyl]furane als anti-pneumocystis carinii Mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69823707T Expired - Fee Related DE69823707T2 (de) 1998-02-27 1998-07-23 2,4 -Bis [(4-Amidino)phenyl]furane als anti-pneumocystis carinii Mittel

Country Status (7)

Country Link
US (2) US6008247A (de)
EP (2) EP1130019B1 (de)
JP (1) JP2000256343A (de)
AU (1) AU747448B2 (de)
CA (1) CA2242794A1 (de)
DE (2) DE69802777T2 (de)
GB (1) GB2334716B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774144B1 (en) 1999-11-01 2004-08-10 The University Of North Carolina At Chapel Hill Methods and formulations for the treatment of infectious bursal disease in avian subjects
AU1450401A (en) * 1999-11-01 2001-05-14 Auburn University Methods and formulations for the treatment of infectious bursal disease in avian subjects
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
US7163955B2 (en) * 2001-01-13 2007-01-16 The University Of North Carolina At Chapel Hill Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
US20030199521A1 (en) * 2001-01-13 2003-10-23 Dykstra Christine C. Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
CN1658852A (zh) * 2001-08-31 2005-08-24 神经化学（国际）有限公司 用于治疗淀粉样变性的脒衍生物
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
AR047938A1 (es) * 2003-08-25 2006-03-15 Combinatorx Inc Formulaciones, conjugados y combinaciones de farmacos para el tratamiento de neoplasmas
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
US7947741B2 (en) * 2004-03-17 2011-05-24 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
CN112480090B (zh) * 2020-11-25 2023-07-21 浙江工业大学 一种含有吲哚啉和5-芳基呋喃骨架的化合物及其制备与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3359284A (en) * 1966-03-18 1967-12-19 Yissum Res Dev Co Process for preparing tetraphenylfuran
US3470151A (en) * 1966-05-17 1969-09-30 Beecham Group Ltd Furyl- and thienyl-penicillins and salts thereof
US5723288A (en) * 1994-05-06 1998-03-03 The University Of North Carolina At Chapel Hill Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor
US5667975A (en) * 1994-05-06 1997-09-16 The University Of North Carolina Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans
US5521189A (en) * 1994-05-06 1996-05-28 The University Of Nc At Ch Methods of treating pneumocystis carinii pneumonia
US5602172A (en) * 1994-05-06 1997-02-11 The University Of North Carolina At Chapel Hill Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor
IL115875A (en) * 1994-11-14 2000-12-06 Univ Georgia State Res Found Methods of inhibiting pneumocystis carinii pneumonia giardia lamblia and cryptosporidium parvum in an animal subject and compounds useful therefor
US5668165A (en) * 1995-06-07 1997-09-16 Scriptgen Pharmaceuticals, Inc. Small molecule inhibition of RNA/ligand binding
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents

Also Published As

Publication number Publication date
EP1130019A1 (de) 2001-09-05
EP0941991A1 (de) 1999-09-15
GB2334716A (en) 1999-09-01
CA2242794A1 (en) 1999-08-27
GB2334716B (en) 2000-05-17
JP2000256343A (ja) 2000-09-19
AU7745398A (en) 1999-09-09
EP0941991B1 (de) 2001-12-05
AU747448B2 (en) 2002-05-16
DE69823707D1 (de) 2004-06-09
US6127554A (en) 2000-10-03
EP1130019B1 (de) 2004-05-06
DE69802777T2 (de) 2002-08-08
DE69823707T2 (de) 2005-04-28
GB9816054D0 (en) 1998-09-23
US6008247A (en) 1999-12-28

Similar Documents

Publication Publication Date Title
DE60131971D1 (de) 1,3,8-TRIAZA-SPIROi4,5 DECAN-4-ONDERIVATIVE ALS NEUROKININREZEPTORANTAGONISTEN
BR9710372B1 (pt) composto, e, composiÇço farmacÊutica.
DE69838405D1 (de) Mikrostrukturierte, kosmetisch verträgliche Zusamensetzungen
BR9908467B1 (pt) composiÇço de xampu aquosa.
TR199901077A3 (tr) Ispençiyari formülasyonlar.
DE69509359T2 (de) Arylsubstituierte 5,5 kondensierte aromatische stickstoffverbindungen als entzuendungshemmende mittel
DE69802777T2 (de) 2,4-Bis(4-Amidino)phenylfurane als anti-pneumocystis carinii Mittel
ATE338033T1 (de) Thiophen- und thiazolsulfonamide als antineoplastische mittel
ATE219490T1 (de) Indazoleamid-verbindungen als serotoninergene mittel
ID21413A (id) Turunan-turunan 1,3,8,-triaza-spiro (4,5) dekan-4-on
DE69711649T2 (de) P1, p4-dithio-p2,p3-monochloromethylen 5',5'''-diadenosin-p1,p4-tetraphosphat verwendet als anti-thrombose mittel
DE60210598D1 (de) 3,7-DIAZABICYCLOc3.3.1Ü-FORMULIERUNGEN ALS ANTIARRHYTHMIKA
DE60025958D1 (de) 14,15-beta-methylen substituierte androgene
DE69714145D1 (de) 1,4-Diaryl-2-fluoro-2-butene als insectizide und akarizide Mittel
NL1010854C2 (nl) Bedieningscilinder.
ATE264305T1 (de) Antivirale mittel
IT1307041B1 (it) Composizione pesticida.
BR9916537B1 (pt) composição de fragráncia, e, produto.
DE69906149D1 (de) 4,5-azolo-oxindole
FR2763498B1 (fr) Endoscope, en particulier mediastinoscope
DZ2548A1 (fr) Compositions de sertraline solubilisée.
DE60213084D1 (de) 3,7-DIAZABICYCLOc3.3.1Ü-FORMULIERUNGEN ALS ANTIARRHYTHMIKA
ATE211909T1 (de) Synergistisches immunosuppressives eine 2, 2'-bi- 1h-pyrrolverbindung enthaltendes mittel
DE69905278D1 (de) Insectizide mittel
ID26368A (id) Turunan-turunan 2 deoksi higromisin

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee