DE69737032D1 - Mutanten von streptococcaltoxinen und vefahren zu deren anwendung - Google Patents
Mutanten von streptococcaltoxinen und vefahren zu deren anwendungInfo
- Publication number
- DE69737032D1 DE69737032D1 DE69737032T DE69737032T DE69737032D1 DE 69737032 D1 DE69737032 D1 DE 69737032D1 DE 69737032 T DE69737032 T DE 69737032T DE 69737032 T DE69737032 T DE 69737032T DE 69737032 D1 DE69737032 D1 DE 69737032D1
- Authority
- DE
- Germany
- Prior art keywords
- spe
- toxin
- methods
- vaccine
- streptococcaltoxines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003053 toxin Substances 0.000 abstract 5
- 231100000765 toxin Toxicity 0.000 abstract 5
- 108700012359 toxins Proteins 0.000 abstract 5
- 229960005486 vaccine Drugs 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100001160 nonlethal Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3293096P | 1996-12-06 | 1996-12-06 | |
| PCT/US1997/022228 WO1998024911A2 (en) | 1996-12-06 | 1997-12-05 | Mutants of streptococcal toxin a and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69737032D1 true DE69737032D1 (de) | 2007-01-11 |
Family
ID=21867628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69737032T Expired - Lifetime DE69737032D1 (de) | 1996-12-06 | 1997-12-05 | Mutanten von streptococcaltoxinen und vefahren zu deren anwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6913755B2 (de) |
| EP (1) | EP0948624B1 (de) |
| JP (1) | JP2001505439A (de) |
| KR (1) | KR100548663B1 (de) |
| CN (1) | CN1211487C (de) |
| AT (1) | ATE346860T1 (de) |
| AU (1) | AU7625798A (de) |
| BR (1) | BR9714641A (de) |
| CA (1) | CA2273822A1 (de) |
| DE (1) | DE69737032D1 (de) |
| WO (1) | WO1998024911A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW517061B (en) * | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
| CN1211487C (zh) * | 1996-12-06 | 2005-07-20 | 明尼苏达大学董事会 | 链球菌毒素a突变体及其使用方法 |
| US7087235B2 (en) * | 1997-06-25 | 2006-08-08 | The United States Of America As Represented By The Secretary Of The Army | Fusion protein of streptococcal pyrogenic exotoxins |
| US6872394B1 (en) | 1997-12-02 | 2005-03-29 | Idaho Research Foundation, Inc. | Non-toxic immune stimulating enterotoxin compositions |
| US20040236082A1 (en) * | 2001-04-13 | 2004-11-25 | Marshall Matthew J. | Modified staphylococcal enterotoxins and expression systems therefore |
| SE0102327D0 (sv) * | 2001-06-28 | 2001-06-28 | Active Biotech Ab | A novel engineered superantigen for human therapy |
| EP1461433A1 (de) * | 2001-11-26 | 2004-09-29 | U.S. Medical Research Institute of Infectious Diseases | Bakterielle superantigen-impfstoffe |
| CN101622224B (zh) * | 2007-03-01 | 2015-10-07 | 巴斯夫欧洲公司 | 借助eddn生产teta的新方法 |
| KR20180100412A (ko) | 2016-01-10 | 2018-09-10 | 네오티엑스 테라퓨틱스 엘티디. | 면역강화제에 의해 증진되는 초항원 매개된 암 면역요법 |
| WO2019218022A1 (en) * | 2018-05-16 | 2019-11-21 | Griffith University | Streptococcal toxic shock syndrome |
| AU2020275142A1 (en) | 2019-05-15 | 2021-12-16 | Neotx Therapeutics Ltd. | Cancer treatment |
| CN115484978A (zh) | 2020-03-05 | 2022-12-16 | 尼奥克斯医疗有限公司 | 使用免疫细胞治疗癌症的方法和组合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172126A (en) * | 1976-11-08 | 1979-10-23 | Sankyo Company Limited | Method for the inactivation of microbial toxins and attenuation of vaccines |
| US4784948A (en) | 1983-08-10 | 1988-11-15 | The Rockefeller University | Production of streptococcal m protein immunogens and molecular probes |
| US5298396A (en) | 1989-11-15 | 1994-03-29 | National Jewish Center For Immunology And Respiratory Medicine | Method for identifying T cells disease involved in autoimmune disease |
| US5336598A (en) | 1989-11-15 | 1994-08-09 | National Jewish Center For Immunology And Respiratory Medicine | Method for diagnosing a superantigen caused pathologial condition via assay of T-cells |
| JPH08500328A (ja) | 1992-01-28 | 1996-01-16 | ナショナル ジューイッシュ センター フォア イミュノロジィ アンド レスパラトリィ メディスン | 突然変異したスーパー抗原の保護作用 |
| DK0832241T3 (da) | 1995-06-07 | 2005-08-01 | Univ Minnesota | Streptokoktoksin A-mutanter og anvendelsesfremgangsmåder |
| CN1211487C (zh) * | 1996-12-06 | 2005-07-20 | 明尼苏达大学董事会 | 链球菌毒素a突变体及其使用方法 |
-
1997
- 1997-12-05 CN CNB971816263A patent/CN1211487C/zh not_active Expired - Fee Related
- 1997-12-05 AT AT97949752T patent/ATE346860T1/de not_active IP Right Cessation
- 1997-12-05 DE DE69737032T patent/DE69737032D1/de not_active Expired - Lifetime
- 1997-12-05 AU AU76257/98A patent/AU7625798A/en not_active Abandoned
- 1997-12-05 WO PCT/US1997/022228 patent/WO1998024911A2/en active IP Right Grant
- 1997-12-05 JP JP52579498A patent/JP2001505439A/ja not_active Ceased
- 1997-12-05 BR BR9714641-2A patent/BR9714641A/pt not_active Application Discontinuation
- 1997-12-05 KR KR1019997005002A patent/KR100548663B1/ko not_active IP Right Cessation
- 1997-12-05 US US09/308,830 patent/US6913755B2/en not_active Expired - Fee Related
- 1997-12-05 CA CA002273822A patent/CA2273822A1/en not_active Abandoned
- 1997-12-05 EP EP97949752A patent/EP0948624B1/de not_active Expired - Lifetime
-
2005
- 2005-07-05 US US11/175,121 patent/US20060041107A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1246151A (zh) | 2000-03-01 |
| WO1998024911A3 (en) | 1998-08-20 |
| EP0948624B1 (de) | 2006-11-29 |
| US20020086813A1 (en) | 2002-07-04 |
| JP2001505439A (ja) | 2001-04-24 |
| ATE346860T1 (de) | 2006-12-15 |
| US6913755B2 (en) | 2005-07-05 |
| WO1998024911A2 (en) | 1998-06-11 |
| EP0948624A2 (de) | 1999-10-13 |
| CA2273822A1 (en) | 1998-06-11 |
| AU7625798A (en) | 1998-06-29 |
| US20060041107A1 (en) | 2006-02-23 |
| CN1211487C (zh) | 2005-07-20 |
| BR9714641A (pt) | 2002-01-22 |
| KR100548663B1 (ko) | 2006-02-03 |
| KR20000069316A (ko) | 2000-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |