DE69720459D1 - Dosiervorrichtung mit erweitertem dynamikbereich - Google Patents

Dosiervorrichtung mit erweitertem dynamikbereich

Info

Publication number
DE69720459D1
DE69720459D1 DE69720459T DE69720459T DE69720459D1 DE 69720459 D1 DE69720459 D1 DE 69720459D1 DE 69720459 T DE69720459 T DE 69720459T DE 69720459 T DE69720459 T DE 69720459T DE 69720459 D1 DE69720459 D1 DE 69720459D1
Authority
DE
Germany
Prior art keywords
dispenser
pump
droplet
flow rate
dynamic range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69720459T
Other languages
English (en)
Other versions
DE69720459T2 (de
Inventor
C Tisone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biodot Inc
Original Assignee
Biodot Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/687,712 external-priority patent/US5743960A/en
Priority claimed from US08/686,957 external-priority patent/US5741554A/en
Priority claimed from US08/687,711 external-priority patent/US5738728A/en
Application filed by Biodot Inc filed Critical Biodot Inc
Publication of DE69720459D1 publication Critical patent/DE69720459D1/de
Application granted granted Critical
Publication of DE69720459T2 publication Critical patent/DE69720459T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/30—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages
    • B05B1/3033—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head
    • B05B1/304—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head the controlling element being a lift valve
    • B05B1/3046—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head the controlling element being a lift valve the valve element, e.g. a needle, co-operating with a valve seat located downstream of the valve element and its actuating means, generally in the proximity of the outlet orifice
    • B05B1/3053—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head the controlling element being a lift valve the valve element, e.g. a needle, co-operating with a valve seat located downstream of the valve element and its actuating means, generally in the proximity of the outlet orifice the actuating means being a solenoid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/02—Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling time, or sequence, of delivery
    • B05B12/06—Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling time, or sequence, of delivery for effecting pulsating flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B9/00—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
    • B05B9/03—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
    • B05B9/04—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump
    • B05B9/0403—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump with pumps for liquids or other fluent material
    • B05B9/0413—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump with pumps for liquids or other fluent material with reciprocating pumps, e.g. membrane pump, piston pump, bellow pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/2489—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device an atomising fluid, e.g. a gas, being supplied to the discharge device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1041—Ink-jet like dispensers

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Coating Apparatus (AREA)
DE69720459T 1996-07-26 1997-07-25 Dosiervorrichtung mit erweitertem dynamikbereich Expired - Lifetime DE69720459T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/687,712 US5743960A (en) 1996-07-26 1996-07-26 Precision metered solenoid valve dispenser
US08/686,957 US5741554A (en) 1996-07-26 1996-07-26 Method of dispensing a liquid reagent
US08/687,711 US5738728A (en) 1996-07-26 1996-07-26 Precision metered aerosol dispensing apparatus
PCT/US1997/013322 WO1998004358A1 (en) 1996-07-26 1997-07-25 Dispensing apparatus having improved dynamic range

Publications (2)

Publication Number Publication Date
DE69720459D1 true DE69720459D1 (de) 2003-05-08
DE69720459T2 DE69720459T2 (de) 2004-01-29

Family

ID=27418475

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69720459T Expired - Lifetime DE69720459T2 (de) 1996-07-26 1997-07-25 Dosiervorrichtung mit erweitertem dynamikbereich

Country Status (8)

Country Link
EP (1) EP0912253B1 (de)
JP (1) JP2000516526A (de)
CN (1) CN1093782C (de)
AT (1) ATE235966T1 (de)
AU (1) AU4145997A (de)
CA (1) CA2260840A1 (de)
DE (1) DE69720459T2 (de)
WO (1) WO1998004358A1 (de)

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US6537505B1 (en) 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
EP0941961B1 (de) 1998-03-13 2001-10-31 Robatech AG Anlage zum Fördern einer Flüssigkeit und Verwendung der Anlage
JP3562968B2 (ja) * 1998-08-14 2004-09-08 富士写真フイルム株式会社 試験片、その製造方法および装置並びにその読取方法および装置
EP1099483B1 (de) * 1999-11-11 2009-02-11 Allegro Technologies Limited Abgabe von flüssigen Tropfen
US6706538B1 (en) * 2000-02-29 2004-03-16 Boston Innovation Inc. Microvolume liquid dispensing array
US6620383B1 (en) * 2000-02-29 2003-09-16 Boston Innovation Inc. Microvolume liquid dispensing device
DE10017105A1 (de) * 2000-04-06 2001-10-11 Basf Ag Verfahren und Vorrichtung zur Herstellung von Biopolymer-Feldern
US6902702B1 (en) * 2000-08-16 2005-06-07 University Health Network Devices and methods for producing microarrays of biological samples
US6911181B1 (en) * 2000-10-03 2005-06-28 Isis Pharmaceuticals, Inc. Self-dispensing storage device
CH695544A5 (de) * 2000-11-17 2006-06-30 Tecan Trading Ag Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben.
US6669909B2 (en) * 2001-03-26 2003-12-30 Allegro Technologies Limited Liquid droplet dispensing
US6991825B2 (en) * 2002-05-10 2006-01-31 Asm Assembly Automation Ltd. Dispensation of controlled quantities of material onto a substrate
US7459128B2 (en) 2002-08-13 2008-12-02 Molecular Bioproducts, Inc. Microfluidic mixing and dispensing
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US7592185B2 (en) 2004-02-17 2009-09-22 Molecular Bioproducts, Inc. Metering doses of sample liquids
EP1771249A4 (de) * 2004-06-07 2010-02-24 Irm Llc Ausgabesysteme, software und verwandte verfahren
CN100578228C (zh) 2005-09-09 2010-01-06 博奥生物有限公司 一种微量液体精密分配仪器及其使用方法
CN101310169B (zh) * 2005-11-16 2011-06-08 株式会社日立制作所 液滴生成运送方法和装置以及粒子操作装置
KR101600432B1 (ko) * 2007-03-08 2016-03-08 무사시 엔지니어링 가부시키가이샤 액적 토출 장치 및 방법
DE102007023014A1 (de) * 2007-05-15 2008-11-27 Kba-Metronic Ag Verfahren und System zur Dosierung und zum Aufbringen einer Reagenzflüssigkeit
EP2225043B1 (de) 2007-12-10 2017-03-08 Ascensia Diabetes Care Holdings AG Verfahren zur ablagerung von reagenzmaterial in einem testsensor
WO2010126586A1 (en) * 2009-04-27 2010-11-04 Aardvark Medical, Llc Irrigation and aspiration devices and methods
JP5691178B2 (ja) * 2010-01-22 2015-04-01 凸版印刷株式会社 分注方法及び分注装置
CN101987302A (zh) * 2010-10-21 2011-03-23 孔兵 快速多功能液体操作装置
WO2013044583A1 (zh) * 2011-09-28 2013-04-04 Wu Yi 便携式双组分高压喷注机
EP2780722B1 (de) 2011-11-16 2020-06-24 Leica Biosystems Melbourne Pty Ltd Automatisiertes system und verfahren zur behandlung von gewebeproben auf objektträgern
CN102489422B (zh) * 2011-11-18 2015-04-22 江苏大学 一种基于隔膜和电磁激振器的药液喷射装置
CN102514373B (zh) * 2011-11-18 2015-03-11 华南理工大学 一种喷射墨滴的方法及装置
JP5917925B2 (ja) 2012-01-27 2016-05-18 武蔵エンジニアリング株式会社 液滴形成装置および液滴形成方法
ES2385968B1 (es) * 2012-03-06 2013-06-14 Goizper, S. Coop. Aplicador de fluidos con capacidad de dosificacion
EP2662139A1 (de) * 2012-05-08 2013-11-13 Roche Diagniostics GmbH Ventil zur Ausgabe einer Flüssigkeit
TWI548462B (zh) * 2012-05-30 2016-09-11 陳文賓 高黏度液體霧化裝置
CN103575634B (zh) * 2012-08-10 2018-07-17 深圳迈瑞生物医疗电子股份有限公司 一种流式仪器及其液路系统、方法
CN103263992A (zh) * 2013-05-31 2013-08-28 江南大学 一种自动喷胶装置
CN104841298B (zh) * 2014-02-14 2018-08-10 沈如华 一种全自动调色机既大量注浆又微量注浆的方法及装置
CN103894312B (zh) * 2014-03-28 2016-04-13 郑州格兰高环境工程有限公司 智能移动式胶水补给系统
JP6933583B2 (ja) * 2015-05-20 2021-09-08 ユニバーシティ オブ メリーランド， カレッジ パーク 連続気相を伴うマイクロ流体チップにおける水滴の生成及び捕捉
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CN107091765B (zh) * 2017-05-12 2019-08-16 杭州依美洛克医学科技有限公司 免疫组化染色仪的注射泵装置
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CN107377307A (zh) * 2017-08-25 2017-11-24 江苏瑞合硕电子科技有限公司 流体计量装置
CN107617519A (zh) * 2017-09-22 2018-01-23 丰汉电子(上海)有限公司 脉冲式离型剂喷涂用电磁喷嘴
CN107971182B (zh) * 2017-12-20 2020-07-10 青岛华翔汽车顶棚系统有限公司 自动涂胶机
CN110833944A (zh) * 2018-08-18 2020-02-25 湖南迪宏物联科技有限公司 喷淋系统、控制方法及装置
CN109253947B (zh) * 2018-10-19 2020-11-06 西北工业大学 一种负压环境下高温熔融金属液滴碰壁实验装置及方法
CN109772633A (zh) * 2019-01-03 2019-05-21 湖州三杭蒙特费罗电梯部件有限公司 电梯导轨自动喷漆生产线
CN109569755B (zh) * 2019-01-15 2024-03-12 苏州汶颢微流控技术股份有限公司 液滴量产装置
CN109999724A (zh) * 2019-04-22 2019-07-12 苏州高迈新能源有限公司 流量控制系统及实验装置
US20220214252A1 (en) * 2019-05-17 2022-07-07 Curiox Biosystems Pte Ltd. Methods, devices, and apparatus for dispensing and aspirating liquids on array plates
KR102208785B1 (ko) * 2019-08-05 2021-01-28 경희대학교 산학협력단 미세액적 생성 장치
JP2021165652A (ja) * 2020-04-06 2021-10-14 キヤノンメディカルシステムズ株式会社 自動分析装置
CN112704890B (zh) * 2020-11-05 2023-02-28 中国恩菲工程技术有限公司 液体进料装置和液体进料控制方法
WO2022145984A1 (en) * 2020-12-30 2022-07-07 Seegene, Inc. Solution dispenser device and control method in sample processing system
EP4105615A1 (de) * 2021-06-18 2022-12-21 Harro Höfliger Verpackungsmaschinen GmbH Kalibriereinrichtung und verfahren zur dosierung von darreichungseinheiten
CN114345234B (zh) * 2022-01-10 2023-02-03 北京航空航天大学 一种基于水锤效应的液滴发生器及其工作方法
CN114643019B (zh) * 2022-05-18 2022-08-12 山东彩客新材料有限公司 一种data生产用双氧水液下滴加分布装置
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Also Published As

Publication number Publication date
WO1998004358A1 (en) 1998-02-05
JP2000516526A (ja) 2000-12-12
CN1231621A (zh) 1999-10-13
AU4145997A (en) 1998-02-20
EP0912253A1 (de) 1999-05-06
CA2260840A1 (en) 1998-02-05
DE69720459T2 (de) 2004-01-29
CN1093782C (zh) 2002-11-06
ATE235966T1 (de) 2003-04-15
EP0912253B1 (de) 2003-04-02

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