DE69720160T2 - Verwendung von 11-substituierten Steroiden zur Herstellung von Medikamenten mit unterschiedlicher östrogenischen Wirkung - Google Patents

Verwendung von 11-substituierten Steroiden zur Herstellung von Medikamenten mit unterschiedlicher östrogenischen Wirkung

Info

Publication number
DE69720160T2
DE69720160T2 DE69720160T DE69720160T DE69720160T2 DE 69720160 T2 DE69720160 T2 DE 69720160T2 DE 69720160 T DE69720160 T DE 69720160T DE 69720160 T DE69720160 T DE 69720160T DE 69720160 T2 DE69720160 T2 DE 69720160T2
Authority
DE
Germany
Prior art keywords
drugs
manufacture
estrogenic effects
substituted steroids
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69720160T
Other languages
English (en)
Other versions
DE69720160D1 (de
Inventor
Yamina Bouali
Francois Nique
Daniel Philibert
Jean-Georges Teutsch
De Velde Patrick Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE69720160D1 publication Critical patent/DE69720160D1/de
Application granted granted Critical
Publication of DE69720160T2 publication Critical patent/DE69720160T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69720160T 1996-12-23 1997-12-22 Verwendung von 11-substituierten Steroiden zur Herstellung von Medikamenten mit unterschiedlicher östrogenischen Wirkung Expired - Lifetime DE69720160T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615828A FR2757399B1 (fr) 1996-12-23 1996-12-23 Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee

Publications (2)

Publication Number Publication Date
DE69720160D1 DE69720160D1 (de) 2003-04-30
DE69720160T2 true DE69720160T2 (de) 2003-11-13

Family

ID=9498982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69720160T Expired - Lifetime DE69720160T2 (de) 1996-12-23 1997-12-22 Verwendung von 11-substituierten Steroiden zur Herstellung von Medikamenten mit unterschiedlicher östrogenischen Wirkung

Country Status (7)

Country Link
US (2) US5981516A (de)
EP (1) EP0850647B1 (de)
JP (1) JP4263264B2 (de)
AT (1) ATE235243T1 (de)
DE (1) DE69720160T2 (de)
ES (1) ES2196281T3 (de)
FR (1) FR2757399B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2757519B1 (fr) * 1996-12-23 1999-06-11 Hoechst Marion Roussel Inc Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
US6172052B1 (en) 1998-12-04 2001-01-09 Research Triangle Institute 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
DE19929715A1 (de) 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
CA2623883C (en) 2005-09-27 2013-01-29 Paradigm Spine, Llc Interspinous vertebral stabilization devices
US20080103116A1 (en) * 2006-11-01 2008-05-01 Jennings-Spring Barbara L Method of treatment and compositions of D-chiro inositol and phosphates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
US4978657A (en) * 1981-01-09 1990-12-18 Roussel Uclaf Novel 11β-substituted-19-nor-steroids
FR2640977A2 (en) * 1982-06-11 1990-06-29 Roussel Uclaf New position-11 substituted 19-norsteroids and their application as medicinal products.
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR2618783B1 (fr) * 1987-07-30 1991-02-01 Roussel Uclaf Nouveaux 17-aryle steroides, leurs procedes et des intermediaires de preparation comme medicaments et les compositions pharmaceutiques les renfermant
US4925816A (en) * 1987-08-29 1990-05-15 Ngk Insulators, Ltd. Novel solid solution, heat-resistant sintered body and method of producing the same
FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
US5981516A (en) 1999-11-09
JPH10182466A (ja) 1998-07-07
ES2196281T3 (es) 2003-12-16
ATE235243T1 (de) 2003-04-15
JP4263264B2 (ja) 2009-05-13
EP0850647B1 (de) 2003-03-26
EP0850647A1 (de) 1998-07-01
FR2757399B1 (fr) 1999-12-17
US6011026A (en) 2000-01-04
DE69720160D1 (de) 2003-04-30
FR2757399A1 (fr) 1998-06-26

Similar Documents

Publication Publication Date Title
ROGER et al. Mitogenic effects of thyrotropin and adenosine 3′, 5′-monophosphate in differentiated normal human thyroid cells in vitro
GEP20022766B (en) Steroid Sulphatase Inhibitors
DE69737510D1 (de) Verwendung eines unverkapselten anti-krebs-wirkstoffs zur herstellung einer zubereitung zur behandlung von neoplasmen durch inhalation
CA2168850A1 (en) Estrogenic compounds as anti-mitotic agents
ZA899671B (en) Phosphinic acid substituted steroids as inhibitors of steroid 5-alpha-reductase
DE69432752D1 (de) Zusammensetzung zur substitutionstherapie, die mindestens ein progestogen und mindestens ein oestrogen enthält
DE3782468D1 (de) Verfahren zur behandlung von maennlicher sexueller dysfunktion.
KR910004653A (ko) 스테로이드 5-α-환원효소의 억제제로서의 7-케토 또는 히드록시 3,5-디엔 스테로이드
AU666916B2 (en) Novel 19-nor steroids having a thiocarbon-containing chain in the 11beta position, a method for preparing same and intermediates therefor, medicinal uses thereof and compositions containing said steroids
KR880012633A (ko) C_17 내지 C_20 리아제 억제제로서 유용한 17β-(사이클로프로필아미노)안드로스트-5-엔-3β-올 및 관련 화합물
DE69720160T2 (de) Verwendung von 11-substituierten Steroiden zur Herstellung von Medikamenten mit unterschiedlicher östrogenischen Wirkung
RU94026906A (ru) Новые композиции в форме подкожных инплантантов на основе производных нормегестрола, способ их получения и применения
ATE137965T1 (de) Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege
NZ236614A (en) Therapeutic composition containing corticosteroid and igf-i, the igf-i reducing or preventing the adverse effects of the corticosteroid
DE69314570D1 (de) Verfahren zur Herstellung Taurin-konjugierter Gallensäure
ES546372A0 (es) Procedimiento para preparar nuevos esteroides sustituidos en posicion 10.
KR880002532A (ko) 플래티넘 유도체 및 암 치료제(Platinum Derivatives and Cancer Treatments)
DE69517356D1 (de) Verwendung von aromatischen Steroiden, die in der 3-Stelle bei einer disubstituierte-aminoalkoxy Kette substituiert sind, zur Herstellung eines Medikaments zur Kontrolle der Fertilität, insbesondere männlicher Fertilität
DE69230069T2 (de) Steroide enthaltende zusammensetzungen zur anwendung am auge und ihre verwendung zur behandlung des glaukoms
EP0365613A4 (en) Combination of tobramycin and steroids for topical ophthalmic use
Yahr The role of aromatization in androgen stimulation of gerbil scent marking
AP9901567A0 (en) Steroids substituted in composition 11, their preparation process, their use as medicaments and the pharmaceutical compounds containing them.
Nutting et al. Estradienes and 2-oxaestradienes. Potent oral anabolic-androgenic agents
Walker et al. The comparative potency of various steroids to complete the priming process for lordosis in guinea pigs
DE69213268D1 (de) Verfahren zur Herstellung eines feinen dendritischen Pulvers und nach diesem Verfahren erzeugtes Pulver

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC