DE69717988D1 - Topische verabreichung von premafloxacin zur behandlung von systemischen bakteriellen erkrankungen - Google Patents
Topische verabreichung von premafloxacin zur behandlung von systemischen bakteriellen erkrankungenInfo
- Publication number
- DE69717988D1 DE69717988D1 DE69717988T DE69717988T DE69717988D1 DE 69717988 D1 DE69717988 D1 DE 69717988D1 DE 69717988 T DE69717988 T DE 69717988T DE 69717988 T DE69717988 T DE 69717988T DE 69717988 D1 DE69717988 D1 DE 69717988D1
- Authority
- DE
- Germany
- Prior art keywords
- premafloxacin
- bacterial diseases
- topical administration
- systemic bacterial
- treating systemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229950002166 premafloxacin Drugs 0.000 title abstract 3
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- SUQUWONDIBHQOZ-NWDGAFQWSA-N premafloxacin Chemical compound C1[C@H]([C@H](C)NC)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1OC SUQUWONDIBHQOZ-NWDGAFQWSA-N 0.000 title abstract 2
- 230000009885 systemic effect Effects 0.000 title abstract 2
- 238000011200 topical administration Methods 0.000 title 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- YWKJNRNSJKEFMK-PQFQYKRASA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound N([C@@H]1C(N2C(=C(C[N+]=3C=4CCCCC=4C=CC=3)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 YWKJNRNSJKEFMK-PQFQYKRASA-N 0.000 abstract 1
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 abstract 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- WYUSVOMTXWRGEK-HBWVYFAYSA-N cefpodoxime Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(O)=O)C(=O)C(=N/OC)\C1=CSC(N)=N1 WYUSVOMTXWRGEK-HBWVYFAYSA-N 0.000 abstract 1
- 229960005090 cefpodoxime Drugs 0.000 abstract 1
- 229950009592 cefquinome Drugs 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960000740 enrofloxacin Drugs 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 229960002518 gentamicin Drugs 0.000 abstract 1
- -1 premafloxacin ester Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processing Of Solid Wastes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64409196A | 1996-05-10 | 1996-05-10 | |
| PCT/US1997/007124 WO1997042954A1 (en) | 1996-05-10 | 1997-05-05 | Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69717988D1 true DE69717988D1 (de) | 2003-01-30 |
| DE69717988T2 DE69717988T2 (de) | 2003-07-24 |
Family
ID=24583416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69717988T Expired - Fee Related DE69717988T2 (de) | 1996-05-10 | 1997-05-05 | Topische verabreichung von premafloxacin zur behandlung von systemischen bakteriellen erkrankungen |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0898477B1 (de) |
| JP (1) | JP2000510842A (de) |
| AT (1) | ATE229805T1 (de) |
| AU (1) | AU721819B2 (de) |
| DE (1) | DE69717988T2 (de) |
| DK (1) | DK0898477T3 (de) |
| ES (1) | ES2188940T3 (de) |
| NZ (2) | NZ332719A (de) |
| TW (1) | TW477707B (de) |
| WO (1) | WO1997042954A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1012232B1 (de) | 1997-09-10 | 2009-10-28 | Vion Pharmaceuticals, Inc. | Genetisch modifizierte, auf tumoren gezielte bakterien mit verminderter virulenz |
| US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| ID21415A (id) * | 1997-12-05 | 1999-06-10 | Upjohn Co | Senyawa-senyawa antibiotik magnesium quinolon |
| MY122454A (en) * | 1998-06-05 | 2006-04-29 | Upjohn Co | Use of oxazolidinones for the preparation of a medicament for transdermal delivery |
| CN1258531C (zh) * | 1999-03-10 | 2006-06-07 | 第一制药株式会社 | 芳香族取代基取代的氨基甲基吡咯烷衍生物 |
| US6962696B1 (en) | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
| DE102004001558A1 (de) * | 2004-01-10 | 2005-08-18 | Bayer Healthcare Ag | Arzneimittel zur topischen Applikation bei Tieren |
| EP2059231A1 (de) * | 2006-08-30 | 2009-05-20 | Intervet International BV | Pharmazeutische zusammensetzungen mit cefquinom |
| JP5324463B2 (ja) * | 2006-12-10 | 2013-10-23 | チョンシー ユー | β−ラクタム抗生物質の経皮送達システム |
| US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
| RU2016115906A (ru) * | 2009-06-10 | 2018-11-28 | Текфилдз Байокем Ко., Лтд. | Композиции или пролекарства противомикробных и родственных противомикробным соединений, обладающие высокой проникающей способностью |
| IN2014KN02583A (de) | 2012-05-16 | 2015-05-08 | Techfields Pharma Co Ltd | |
| JP5795343B2 (ja) * | 2013-01-23 | 2015-10-14 | チョンシー ユー | β−ラクタム抗生物質の経皮送達システム |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3743727A (en) * | 1970-11-16 | 1973-07-03 | Crown Zellerbach Corp | Enhancing tissue penetration of certain antimicrobial agents with dimethyl sulfoxide |
| US4507287A (en) * | 1983-06-20 | 1985-03-26 | Dixon Glen J | Preparation and method for the treatment of acne |
| US4557934A (en) * | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
| CA2095338C (en) * | 1990-11-30 | 2002-04-09 | John Michael Domagala | Individual stereoisomers of 7-¬3-(aminoalkyl)-1-pyrrolidinyl|-quinolonesand naphthyridones as antibacterial agents |
| CN1081103A (zh) * | 1992-09-19 | 1994-01-26 | 蒋明威 | 含喹诺酮类药物的透皮制剂及其制备方法 |
-
1997
- 1997-05-05 ES ES97921434T patent/ES2188940T3/es not_active Expired - Lifetime
- 1997-05-05 AT AT97921434T patent/ATE229805T1/de not_active IP Right Cessation
- 1997-05-05 NZ NZ332719A patent/NZ332719A/xx unknown
- 1997-05-05 TW TW086105947A patent/TW477707B/zh not_active IP Right Cessation
- 1997-05-05 WO PCT/US1997/007124 patent/WO1997042954A1/en active IP Right Grant
- 1997-05-05 EP EP97921434A patent/EP0898477B1/de not_active Expired - Lifetime
- 1997-05-05 NZ NZ336873A patent/NZ336873A/en unknown
- 1997-05-05 JP JP09540887A patent/JP2000510842A/ja not_active Withdrawn
- 1997-05-05 AU AU27470/97A patent/AU721819B2/en not_active Ceased
- 1997-05-05 DK DK97921434T patent/DK0898477T3/da active
- 1997-05-05 DE DE69717988T patent/DE69717988T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000510842A (ja) | 2000-08-22 |
| DK0898477T3 (da) | 2003-03-24 |
| AU721819B2 (en) | 2000-07-13 |
| TW477707B (en) | 2002-03-01 |
| DE69717988T2 (de) | 2003-07-24 |
| AU2747097A (en) | 1997-12-05 |
| NZ332719A (en) | 2000-01-28 |
| EP0898477A1 (de) | 1999-03-03 |
| NZ336873A (en) | 2001-02-23 |
| WO1997042954A1 (en) | 1997-11-20 |
| ATE229805T1 (de) | 2003-01-15 |
| EP0898477B1 (de) | 2002-12-18 |
| ES2188940T3 (es) | 2003-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |