DE69716057D1 - Verfahren und zusammensetzungen zum nachweis von spleiss-mutationen in dihydropyremudine dehydrogenase - Google Patents

Verfahren und zusammensetzungen zum nachweis von spleiss-mutationen in dihydropyremudine dehydrogenase

Info

Publication number
DE69716057D1
DE69716057D1 DE69716057T DE69716057T DE69716057D1 DE 69716057 D1 DE69716057 D1 DE 69716057D1 DE 69716057 T DE69716057 T DE 69716057T DE 69716057 T DE69716057 T DE 69716057T DE 69716057 D1 DE69716057 D1 DE 69716057D1
Authority
DE
Germany
Prior art keywords
compositions
dihydropyremudine
dehydrogenase
splice mutations
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69716057T
Other languages
English (en)
Other versions
DE69716057T2 (de
Inventor
J Gonzalez
Pedro Fernandez-Salguero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Government
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69716057D1 publication Critical patent/DE69716057D1/de
Publication of DE69716057T2 publication Critical patent/DE69716057T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69716057T 1996-03-20 1997-03-19 Verfahren und zusammensetzungen zum nachweis von spleiss-mutationen in dihydropyremudine dehydrogenase Expired - Lifetime DE69716057T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1383596P 1996-03-20 1996-03-20
PCT/US1997/004269 WO1997035034A1 (en) 1996-03-20 1997-03-19 Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations

Publications (2)

Publication Number Publication Date
DE69716057D1 true DE69716057D1 (de) 2002-11-07
DE69716057T2 DE69716057T2 (de) 2003-07-03

Family

ID=21762020

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69716057T Expired - Lifetime DE69716057T2 (de) 1996-03-20 1997-03-19 Verfahren und zusammensetzungen zum nachweis von spleiss-mutationen in dihydropyremudine dehydrogenase

Country Status (8)

Country Link
EP (1) EP0896629B8 (de)
AT (1) ATE225404T1 (de)
AU (1) AU2215897A (de)
CA (1) CA2249364C (de)
DE (1) DE69716057T2 (de)
DK (1) DK0896629T3 (de)
ES (1) ES2185002T3 (de)
WO (1) WO1997035034A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787306B1 (en) 1996-03-20 2004-09-07 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
AU771446B2 (en) * 1996-03-20 2004-03-25 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
WO2001036686A2 (en) * 1999-11-15 2001-05-25 University Of Southern California Genomic polymorphism for predicting therapeutic response
US7005278B2 (en) 2001-03-02 2006-02-28 Danenberg Kathleen D Method of determining dihydropyrimidine dehydrogenase gene expression
US20020142328A1 (en) 2000-12-01 2002-10-03 Danenberg Kathleen D. Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
US6602670B2 (en) 2000-12-01 2003-08-05 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 expression
US7049059B2 (en) 2000-12-01 2006-05-23 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression
US6956111B2 (en) 2001-03-02 2005-10-18 Response Genetics, Inc. Method of determining dihydropyrimidine dehydrogenase gene expression
US6686155B2 (en) 2001-06-14 2004-02-03 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression
FR2884257B1 (fr) * 2005-04-12 2010-11-26 Centre Regional De Lutte Contre Le Cancer Dangers Prevention des toxicites dues au 5-fluorouracile
US8440398B2 (en) 2006-01-25 2013-05-14 Taiho Pharmaceutical Co., Ltd. Method for prediction of sensitivity to 5-fluorouracil-type anticancer agent

Also Published As

Publication number Publication date
DK0896629T3 (da) 2003-02-03
EP0896629B8 (de) 2003-01-02
AU2215897A (en) 1997-10-10
ES2185002T3 (es) 2003-04-16
EP0896629B1 (de) 2002-10-02
WO1997035034A1 (en) 1997-09-25
EP0896629A1 (de) 1999-02-17
CA2249364A1 (en) 1997-09-25
ATE225404T1 (de) 2002-10-15
DE69716057T2 (de) 2003-07-03
CA2249364C (en) 2009-07-07

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA,AS

8364 No opposition during term of opposition