DE69712750D1 - Lösliche tachykinin-antagonisten, deren herstellung und verwendung - Google Patents
Lösliche tachykinin-antagonisten, deren herstellung und verwendungInfo
- Publication number
- DE69712750D1 DE69712750D1 DE69712750T DE69712750T DE69712750D1 DE 69712750 D1 DE69712750 D1 DE 69712750D1 DE 69712750 T DE69712750 T DE 69712750T DE 69712750 T DE69712750 T DE 69712750T DE 69712750 D1 DE69712750 D1 DE 69712750D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- beta
- dap
- cyclo
- asp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000003141 Tachykinin Human genes 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 108060008037 tachykinin Proteins 0.000 title 1
- 235000018417 cysteine Nutrition 0.000 abstract 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 101000713585 Homo sapiens Tubulin beta-4A chain Proteins 0.000 abstract 1
- 125000003130 L-selenocysteinyl group Chemical group O=C([*])[C@@](N([H])[H])([H])C([H])([H])[Se][H] 0.000 abstract 1
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
- 102100036788 Tubulin beta-4A chain Human genes 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002243 furanoses Chemical class 0.000 abstract 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 150000002574 ketohexoses Chemical class 0.000 abstract 1
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003215 pyranoses Chemical group 0.000 abstract 1
- JULROCUWKLNBSN-UHFFFAOYSA-N seleno-DL-cystine Natural products OC(=O)C(N)C[Se][Se]CC(N)C(O)=O JULROCUWKLNBSN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000401A IT1283171B1 (it) | 1996-03-01 | 1996-03-01 | Composti solubili antagonisti delle tachichinine loro preparazione e loro uso in composizioni farmaceutiche |
| PCT/EP1997/000917 WO1997031941A2 (en) | 1996-03-01 | 1997-02-26 | Soluble tachykinin antagonists, the preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69712750D1 true DE69712750D1 (de) | 2002-06-27 |
Family
ID=11373464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69712750T Expired - Lifetime DE69712750D1 (de) | 1996-03-01 | 1997-02-26 | Lösliche tachykinin-antagonisten, deren herstellung und verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6075006A (enExample) |
| EP (1) | EP0894093B1 (enExample) |
| JP (1) | JP2001502656A (enExample) |
| KR (1) | KR19990087385A (enExample) |
| AT (1) | ATE217886T1 (enExample) |
| AU (1) | AU1877197A (enExample) |
| CA (1) | CA2247802A1 (enExample) |
| DE (1) | DE69712750D1 (enExample) |
| IT (1) | IT1283171B1 (enExample) |
| WO (1) | WO1997031941A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2384571C2 (ru) | 2004-04-28 | 2010-03-20 | Такеда Фармасьютикал Компани Лимитед | Конденсированное хинолиновое производное и его применение |
| WO2009072643A1 (en) | 2007-12-03 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use thereof |
| USRE49686E1 (en) | 2008-09-19 | 2023-10-10 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use of same |
| WO2017073764A1 (ja) * | 2015-10-30 | 2017-05-04 | 国立大学法人京都大学 | 新規ｎｋ３受容体アゴニスト |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06509571A (ja) * | 1991-08-08 | 1994-10-27 | エイ・メナリニ・インダストリー・ファーマシューティケ・リウニテ・エスアールエル | タキキニン拮抗薬としての環状ヘキサペプチドの製法およびその薬学的化合物 |
| IT1262902B (it) * | 1992-04-15 | 1996-07-22 | Menarini Farma Ind | Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche. |
-
1996
- 1996-03-01 IT IT96MI000401A patent/IT1283171B1/it active IP Right Grant
-
1997
- 1997-02-26 WO PCT/EP1997/000917 patent/WO1997031941A2/en not_active Ceased
- 1997-02-26 AT AT97905089T patent/ATE217886T1/de active
- 1997-02-26 JP JP09530587A patent/JP2001502656A/ja active Pending
- 1997-02-26 EP EP97905089A patent/EP0894093B1/en not_active Expired - Lifetime
- 1997-02-26 CA CA002247802A patent/CA2247802A1/en not_active Abandoned
- 1997-02-26 US US09/125,542 patent/US6075006A/en not_active Expired - Fee Related
- 1997-02-26 KR KR1019980706800A patent/KR19990087385A/ko not_active Withdrawn
- 1997-02-26 AU AU18771/97A patent/AU1877197A/en not_active Abandoned
- 1997-02-26 DE DE69712750T patent/DE69712750D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6075006A (en) | 2000-06-13 |
| EP0894093A2 (en) | 1999-02-03 |
| JP2001502656A (ja) | 2001-02-27 |
| ITMI960401A0 (enExample) | 1996-03-01 |
| ATE217886T1 (de) | 2002-06-15 |
| WO1997031941A2 (en) | 1997-09-04 |
| IT1283171B1 (it) | 1998-04-16 |
| EP0894093B1 (en) | 2002-05-22 |
| WO1997031941A3 (en) | 1997-10-09 |
| CA2247802A1 (en) | 1997-09-04 |
| ITMI960401A1 (it) | 1997-09-01 |
| KR19990087385A (ko) | 1999-12-27 |
| AU1877197A (en) | 1997-09-16 |
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