DE69707433D1 - Mikropartikel aus einem zusammengesetzten gel als wirkstoffträger - Google Patents

Mikropartikel aus einem zusammengesetzten gel als wirkstoffträger

Info

Publication number
DE69707433D1
DE69707433D1 DE69707433T DE69707433T DE69707433D1 DE 69707433 D1 DE69707433 D1 DE 69707433D1 DE 69707433 T DE69707433 T DE 69707433T DE 69707433 T DE69707433 T DE 69707433T DE 69707433 D1 DE69707433 D1 DE 69707433D1
Authority
DE
Germany
Prior art keywords
microparticles
active principle
controllable
gel
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69707433T
Other languages
English (en)
Other versions
DE69707433T2 (de
Inventor
Alain Lemercier
Remi Meyrueix
Sylvain Huille
Gerard Soula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Technologies SA
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Publication of DE69707433D1 publication Critical patent/DE69707433D1/de
Application granted granted Critical
Publication of DE69707433T2 publication Critical patent/DE69707433T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69707433T 1996-03-15 1997-03-14 Mikropartikel aus einem zusammengesetzten gel als wirkstoffträger Expired - Fee Related DE69707433T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9603546A FR2746035B1 (fr) 1996-03-15 1996-03-15 Microparticules de gel composite susceptibles d'etre utilisees comme vecteur(s) de principe(s) actif(s), l'un de leurs procedes de preparation et leurs applications
PCT/FR1997/000471 WO1997034584A1 (fr) 1996-03-15 1997-03-14 Microparticules de gel composite comme vecteurs de principes actifs

Publications (2)

Publication Number Publication Date
DE69707433D1 true DE69707433D1 (de) 2001-11-22
DE69707433T2 DE69707433T2 (de) 2002-06-06

Family

ID=9490410

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69707433T Expired - Fee Related DE69707433T2 (de) 1996-03-15 1997-03-14 Mikropartikel aus einem zusammengesetzten gel als wirkstoffträger

Country Status (12)

Country Link
US (1) US6180141B1 (de)
EP (1) EP0888110B1 (de)
JP (1) JP2000507934A (de)
AT (1) ATE206912T1 (de)
AU (1) AU2166097A (de)
CA (1) CA2249274A1 (de)
DE (1) DE69707433T2 (de)
DK (1) DK0888110T3 (de)
ES (1) ES2167727T3 (de)
FR (1) FR2746035B1 (de)
PT (1) PT888110E (de)
WO (1) WO1997034584A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686446B2 (en) * 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
FR2786098B1 (fr) 1998-11-20 2003-05-30 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
FR2801226B1 (fr) * 1999-11-23 2002-01-25 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation
CA2304906A1 (en) * 2000-04-07 2001-10-07 1411198 Ontario Limited 13-hode, a regulator of vascular biocompatibility and an inhibitor of cell hyperplasia
FR2814952B1 (fr) * 2000-10-06 2004-01-02 Flamel Tech Sa Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation
FR2814951B1 (fr) * 2000-10-06 2003-01-17 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation
FR2822834B1 (fr) 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
WO2002083194A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
FR2823441B1 (fr) * 2001-04-12 2004-09-10 Thea Lab Composition pharmaceutique a base de macrolides pour application locale en ophtalmologie et son procede de preparation
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
MXPA04009968A (es) 2002-04-09 2004-12-13 Flamel Tech Sa Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s).
KR20050005437A (ko) 2002-04-09 2005-01-13 플라멜 테크놀로지스 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제
FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
US7445796B2 (en) * 2002-08-19 2008-11-04 L. Perrigo Company Pharmaceutically active particles of a monomodal particle size distribution and method
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
FR2860516B1 (fr) 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
FR2868704B1 (fr) * 2004-04-07 2007-09-14 Ethypharm Sa Utilisation de lipides pour ameliorer la biodisponibilite de principes actifs proteiques en formulations injectables sous cutanees ou intra-musculaires
FR2873040B1 (fr) * 2004-07-19 2007-11-30 Flamel Technologies Sa Formulation colloidale d'insuline longue action et sa preparation
CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物，制剂及其用途
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
US9505867B2 (en) 2005-05-31 2016-11-29 Ecole Polytechmique Fédérale De Lausanne Triblock copolymers for cytoplasmic delivery of gene-based drugs
FR2910318B1 (fr) * 2006-12-20 2009-07-03 Flamel Technologies Sa Dispersion de polyaminoacides dans une phase lipidique continue.
FR2914188B1 (fr) * 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
WO2010068432A1 (en) 2008-11-25 2010-06-17 Ecole Polytechnique Federale De Lausanne (Epfl) Block copolymers and uses thereof
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
CN104961827A (zh) 2010-04-06 2015-10-07 阿格罗塞文公司 农用化学品的特异性输送
EP2609119B1 (de) 2010-08-26 2017-10-18 Agrosavfe N.V. Chitinpolysaccharidantigen-bindende proteine
EP2609116A1 (de) 2010-08-26 2013-07-03 Agrosavfe N.V. An insekten bindende antikörper
US10226417B2 (en) * 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
EP2763529A1 (de) 2011-10-06 2014-08-13 Agrosavfe N.V. Herstellung von mikrokapseln für spezifisches targeting
ITMI20111866A1 (it) 2011-10-13 2013-04-14 Bio Ker S R L Polietilenglicoli modificati e loro complessi supramolecolari con macromolecole biologicamente attive
WO2015013510A1 (en) 2013-07-25 2015-01-29 Ecole Polytechnique Federale De Lausanne Epfl High aspect ratio nanofibril materials
CN106470962A (zh) 2014-04-17 2017-03-01 巴斯夫欧洲公司 新型硝化抑制剂和生物农药的组合以及(硫代)磷酸三酰胺和生物农药的组合
CA2955955C (en) 2014-04-17 2024-04-30 Basf Se Combination of (thio)phosphoric acid triamides and herbicides
AU2016214305B2 (en) 2015-02-06 2020-10-08 Basf Se Pyrazole compounds as nitrification inhibitors
AU2016260805A1 (en) 2015-05-12 2017-11-23 Basf Se Thioether compounds as nitrification inhibitors
US20190276376A1 (en) 2016-05-18 2019-09-12 Basf Se Capsules comprising benzylpropargylethers for use as nitrification inhibitors
BR112020012706A2 (pt) 2018-01-09 2020-11-24 Basf Se uso de um composto de silietinil hetarila, composição para uso na redução de nitrificação, mistura agroquímica, métodos para reduzir a nitrificação e para tratamento de um fertilizante ou de uma composição
IL276745B2 (en) 2018-02-28 2023-10-01 Basf Se Use of N-functional alkoxy pyrazole compounds as nitrification inhibitors
WO2019166561A1 (en) 2018-02-28 2019-09-06 Basf Se Use of alkoxypyrazoles as nitrification inhibitors
EP3758491A1 (de) 2018-02-28 2021-01-06 Basf Se Verwendung von pyrazol-propargylethern als nitrifikationsinhibitoren
CN112272519B (zh) * 2018-05-27 2023-01-06 以色列国家农业部、农村发展农业研究组织 用于生物杀虫剂的经由皮克林乳液的单个单元体封装
WO2020002472A1 (en) 2018-06-28 2020-01-02 Basf Se Use of alkynylthiophenes as nitrification inhibitors
WO2020020777A1 (en) 2018-07-23 2020-01-30 Basf Se Use of substituted 2-thiazolines as nitrification inhibitors
ES2969872T3 (es) 2018-07-23 2024-05-23 Basf Se Uso de un compuesto de tiazolidina sustituida como inhibidor de la nitrificación
AR124796A1 (es) 2021-02-02 2023-05-03 Basf Se Acción sinérgica de dcd y alcoxipirazoles como inhibidores de la nitrificación
AR125955A1 (es) 2021-05-21 2023-08-30 Basf Se Uso de un compuesto de alcoxi pirazol n-funcionalizado como inhibidor de nitrificación
WO2022243521A1 (en) 2021-05-21 2022-11-24 Basf Se Use of ethynylpyridine compounds as nitrification inhibitors
WO2022268810A1 (en) 2021-06-21 2022-12-29 Basf Se Metal-organic frameworks with pyrazole-based building blocks
WO2023118418A1 (en) 2021-12-23 2023-06-29 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. A novel glv-phenolamide: biosynthesis and function in protecting plants from herbivore attack
WO2023203066A1 (en) 2022-04-21 2023-10-26 Basf Se Synergistic action as nitrification inhibitors of dcd oligomers with alkoxypyrazole and its oligomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US4976968A (en) * 1989-02-24 1990-12-11 Clinical Technologies Associates, Inc. Anhydrous delivery systems for pharmacological agents
GB2260080A (en) * 1991-10-04 1993-04-07 Rhone Poulenc Rorer Ltd Gelled alginate compositions
FR2732218B1 (fr) * 1995-03-28 1997-08-01 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation

Also Published As

Publication number Publication date
CA2249274A1 (en) 1997-09-25
FR2746035A1 (fr) 1997-09-19
ES2167727T3 (es) 2002-05-16
DK0888110T3 (da) 2002-02-04
EP0888110B1 (de) 2001-10-17
US6180141B1 (en) 2001-01-30
ATE206912T1 (de) 2001-11-15
JP2000507934A (ja) 2000-06-27
EP0888110A1 (de) 1999-01-07
FR2746035B1 (fr) 1998-06-12
DE69707433T2 (de) 2002-06-06
WO1997034584A1 (fr) 1997-09-25
PT888110E (pt) 2002-04-29
AU2166097A (en) 1997-10-10

Similar Documents

Publication Publication Date Title
DE69707433T2 (de) Mikropartikel aus einem zusammengesetzten gel als wirkstoffträger
NO20000913L (no) Sfæriske mikropartikler inneholdende lineære polysakkarider
BR9714015A (pt) Formulações farmacêuticas para distribuição de droga prolongada
IL101241A (en) Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
AU6645300A (en) Stable, electrostatically sprayable topical compositions
PT730443E (pt) Suspensao de etabonato de loteprednol
AU646398B2 (en) Vehicle systems for use in cosmetic compositions
IL148685A0 (en) Surface modified particulate compositions of biologically active substances
ATE277601T1 (de) Verbesserungen bezüglich der verkapselung bioaktiver wirkstoffe
EP0412706A3 (en) Vehicle systems for use in cosmetic compostions
NZ513032A (en) Non-irritating anti-microbial compostitions
EP1677730A4 (de) Arzneimittelabgabevehikel auf basis von umkehrphasen-flüssigkristallmaterialien
ATE395042T1 (de) Darreichungsformen welche mikropartikel und treibgas enthalten
FI903884A0 (fi) Mediumsystem foer anvaendning i kosmetiska kompositioner.
BG104742A (en) Lipophilic microparticles containing a protein drug or antigen and formulation comprising same
CA2194979A1 (en) Solid drug forms containing clathrates of steroid sex hormones
ATE215398T1 (de) Verkapselung von aktiven inhaltsstoffen
CA2152386A1 (en) Fatty ingredient
PL341033A1 (en) Agent for treating creatine fibre
MXPA01011347A (es) Portador de farmaco producido a partir de conjugados de matriz lipida-farmaco (particula lak) para la aplicacion controlada de un agente activo.
DE69408122D1 (de) Zusammensetzung aus mikropartikeln in verdichteter phase und verfahren
NZ513981A (en) Delivery of microparticle formulations using needleless syringe device for sustained-release of bioactive compounds
CA2273272A1 (en) Immediate release drug delivery forms
WO2001047474A3 (de) Verwendung von nanoskaligen deodorantien
TH53082A3 (th) องค์ประกอบและวิธีการของการเตรียมอนุภาคจุลภาคของสารที่ไม่ละลายน้ำ

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee