DE69636058D1 - Gebundene vorstufen von arztneimitteln aufgrund kovalenter verknüpfung mit glutathionanalogen - Google Patents
Gebundene vorstufen von arztneimitteln aufgrund kovalenter verknüpfung mit glutathionanalogenInfo
- Publication number
- DE69636058D1 DE69636058D1 DE69636058T DE69636058T DE69636058D1 DE 69636058 D1 DE69636058 D1 DE 69636058D1 DE 69636058 T DE69636058 T DE 69636058T DE 69636058 T DE69636058 T DE 69636058T DE 69636058 D1 DE69636058 D1 DE 69636058D1
- Authority
- DE
- Germany
- Prior art keywords
- glutathional
- covalency
- analogs
- linking
- products based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/582,966 US5880097A (en) | 1996-01-04 | 1996-01-04 | Tethered prodrugs |
US582966 | 1996-01-04 | ||
PCT/US1996/020042 WO1997025342A1 (en) | 1996-01-04 | 1996-12-20 | Tethered prodrugs by virtue of covalent linkage with analogs of glutathione |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69636058D1 true DE69636058D1 (de) | 2006-05-24 |
DE69636058T2 DE69636058T2 (de) | 2006-11-09 |
Family
ID=24331149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69636058T Expired - Fee Related DE69636058T2 (de) | 1996-01-04 | 1996-12-20 | Gebundene vorstufen von arztneimitteln aufgrund kovalenter verknüpfung mit glutathionanalogen |
Country Status (10)
Country | Link |
---|---|
US (1) | US5880097A (de) |
EP (1) | EP0873355B1 (de) |
JP (1) | JP2000503648A (de) |
AT (1) | ATE323716T1 (de) |
AU (1) | AU1422897A (de) |
DE (1) | DE69636058T2 (de) |
DK (1) | DK0873355T3 (de) |
ES (1) | ES2258272T3 (de) |
PT (1) | PT873355E (de) |
WO (1) | WO1997025342A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030119724A1 (en) * | 1995-11-22 | 2003-06-26 | Ts`O Paul O.P. | Ligands to enhance cellular uptake of biomolecules |
US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
DK1045897T3 (da) | 1998-01-23 | 2002-05-13 | Newbiotics Inc | Enzymatisk katalyserede, terapeutiske midler |
US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
WO2001007088A2 (en) | 1999-07-22 | 2001-02-01 | Newbiotics, Inc. | Methods for treating therapy-resistant tumors |
GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
GB0016447D0 (en) * | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
GB0017852D0 (en) * | 2000-07-20 | 2000-09-06 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
IT1318696B1 (it) * | 2000-09-15 | 2003-08-27 | Pharmacia & Upjohn Spa | Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale. |
GB0029004D0 (en) * | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
WO2002043771A2 (en) | 2000-12-01 | 2002-06-06 | Cell Works Inc. | Conjugates of glycosylated/galactosylated peptide |
US20070249651A1 (en) * | 2001-06-20 | 2007-10-25 | Nerviano Medical Sciences S.R.I. | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
US7172905B2 (en) * | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
US6969592B2 (en) * | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
AU2003247907A1 (en) * | 2002-07-05 | 2004-01-23 | University Of Chicago | Characterization of biochips containing self-assembled monolayers with maldi-tof-ms |
TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
TW200538149A (en) * | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8413635D0 (en) * | 1984-05-29 | 1984-07-04 | Lucas Ind Plc | Liquid level indicators |
JP2919867B2 (ja) * | 1989-09-27 | 1999-07-19 | 千寿製薬株式会社 | 抗腫瘍剤 |
US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
US5786336A (en) * | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
US5545621A (en) * | 1991-04-29 | 1996-08-13 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
US5908919A (en) * | 1993-10-01 | 1999-06-01 | Terrapin Technologies | Urethane mediated, GST specific molecular release systems |
-
1996
- 1996-01-04 US US08/582,966 patent/US5880097A/en not_active Expired - Fee Related
- 1996-12-20 AU AU14228/97A patent/AU1422897A/en not_active Abandoned
- 1996-12-20 EP EP96944416A patent/EP0873355B1/de not_active Expired - Lifetime
- 1996-12-20 WO PCT/US1996/020042 patent/WO1997025342A1/en active IP Right Grant
- 1996-12-20 DE DE69636058T patent/DE69636058T2/de not_active Expired - Fee Related
- 1996-12-20 ES ES96944416T patent/ES2258272T3/es not_active Expired - Lifetime
- 1996-12-20 JP JP9525216A patent/JP2000503648A/ja not_active Ceased
- 1996-12-20 AT AT96944416T patent/ATE323716T1/de not_active IP Right Cessation
- 1996-12-20 DK DK96944416T patent/DK0873355T3/da active
- 1996-12-20 PT PT96944416T patent/PT873355E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
JP2000503648A (ja) | 2000-03-28 |
WO1997025342A1 (en) | 1997-07-17 |
US5880097A (en) | 1999-03-09 |
ATE323716T1 (de) | 2006-05-15 |
PT873355E (pt) | 2006-07-31 |
EP0873355A1 (de) | 1998-10-28 |
ES2258272T3 (es) | 2006-08-16 |
EP0873355B1 (de) | 2006-04-19 |
DK0873355T3 (da) | 2006-08-21 |
AU1422897A (en) | 1997-08-01 |
DE69636058T2 (de) | 2006-11-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |