DE69634851D1 - Immortalisierter Fusionspartner von Kaninchen - Google Patents

Immortalisierter Fusionspartner von Kaninchen

Info

Publication number
DE69634851D1
DE69634851D1 DE69634851T DE69634851T DE69634851D1 DE 69634851 D1 DE69634851 D1 DE 69634851D1 DE 69634851 T DE69634851 T DE 69634851T DE 69634851 T DE69634851 T DE 69634851T DE 69634851 D1 DE69634851 D1 DE 69634851D1
Authority
DE
Germany
Prior art keywords
rabbit
specific
microinjected
lymphoid
oncogene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634851T
Other languages
English (en)
Other versions
DE69634851T2 (de
Inventor
L Knight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Loyola University Chicago
Original Assignee
Loyola University Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loyola University Chicago filed Critical Loyola University Chicago
Application granted granted Critical
Publication of DE69634851D1 publication Critical patent/DE69634851D1/de
Publication of DE69634851T2 publication Critical patent/DE69634851T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
DE69634851T 1995-02-28 1996-02-28 Immortalisierter Fusionspartner von Kaninchen Expired - Lifetime DE69634851T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/396,383 US5675063A (en) 1995-02-28 1995-02-28 Immortalized rabbit hybridoma fusion partner
US396383 1995-02-28
PCT/US1996/002264 WO1996027004A1 (en) 1995-02-28 1996-02-28 An immortalized mammal hybridoma fusion partner

Publications (2)

Publication Number Publication Date
DE69634851D1 true DE69634851D1 (de) 2005-07-21
DE69634851T2 DE69634851T2 (de) 2006-05-04

Family

ID=23566979

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634851T Expired - Lifetime DE69634851T2 (de) 1995-02-28 1996-02-28 Immortalisierter Fusionspartner von Kaninchen

Country Status (7)

Country Link
US (1) US5675063A (de)
EP (1) EP0815213B1 (de)
AT (1) ATE297982T1 (de)
AU (1) AU4989296A (de)
CA (1) CA2214018C (de)
DE (1) DE69634851T2 (de)
WO (1) WO1996027004A1 (de)

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US6921846B1 (en) 1997-11-28 2005-07-26 Duke University Antibody production methods relating to disruption of peripheral tolerance in B lympho-cytes
CA2412650C (en) * 2000-06-14 2011-08-02 Georgetown University Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders
US7569675B2 (en) * 2002-09-11 2009-08-04 Spring Bioscience Corporation High affinity monoclonal antibody for recognizing the progesterone receptor (PR) and method for creating the antibody
US7148332B2 (en) * 2002-09-11 2006-12-12 Spring Bioscience High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody
US8071322B2 (en) * 2002-11-12 2011-12-06 Epitomics, Inc. Method for identifying differentially expressed proteins
US7402409B2 (en) * 2003-01-23 2008-07-22 Epitomics, Inc. Cell fusion method
US7888485B2 (en) * 2003-03-26 2011-02-15 Georgetown University Anti-pleiotrophin antibodies and methods of use thereof
US20050287644A1 (en) * 2004-05-14 2005-12-29 Genesis Biotech Inc. Methods for producing and culturing rabbit-mouse hybridomas and monoclonal antibodies secreted by rabbit-mouse hybridomas
KR101262732B1 (ko) * 2004-06-07 2013-05-09 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Ｂ 형 간염 표면 항원에 대한 토끼 모노클로날 항체 및이것의 사용 방법
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
US7517663B2 (en) * 2005-06-16 2009-04-14 Biocheck, Inc. Rabbit monoclonal antibody against Id1 protein
US7429487B2 (en) 2005-07-05 2008-09-30 Epitomics, Inc. Fusion partner for production of monoclonal rabbit antibodies
WO2008013552A2 (en) * 2005-08-26 2008-01-31 Columbia University Fully human hybridoma fusion partner cell lines
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
EP1934867A2 (de) * 2005-08-31 2008-06-25 Cell Signaling Technology, Inc. Reagentien zum nachweis der proteinphosphorylierung in leukämie-signalwegen
EP1929003A4 (de) 2005-08-31 2009-04-29 Cell Signaling Technology Inc Reagentien zum nachweis von proteinphosphorylierung in karzinom-signalwegen
US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
JP5554925B2 (ja) 2006-01-20 2014-07-23 セル・シグナリング・テクノロジー・インコーポレイテツド ヒト非小細胞肺癌における転座及び変異体ｒｏｓキナーゼ
US7629131B2 (en) * 2006-01-27 2009-12-08 Biocheck, Inc. Rabbit monoclonal antibodies against mouse/human Id3 proteins
EP2447360A1 (de) 2006-04-14 2012-05-02 Cell Signaling Technology, Inc. Gendefekte und Mutante ALK-Kinase in festen menschlichen Tumoren
WO2007127335A2 (en) * 2006-04-27 2007-11-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in atm and atr kinase signaling pathways
WO2007139929A2 (en) * 2006-05-25 2007-12-06 The Burnham Institute For Medical Research Methods for culture and production of single cell populations of human embryonic stem cells
US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
HU0700534D0 (en) * 2006-11-24 2007-10-29 Mezoegazdasagi Biotechnologiai Transgenic animal with enhanced immune response and method for the preparation thereof
EP1972639A3 (de) 2007-03-07 2008-12-03 Cell Signaling Technology, Inc. Reagenzien zur Erkennung von Proteinphosphorylierung in Karzinom-Signalwegen
EP1975184A3 (de) 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serin- oder Threonin-Phosphorylationsorte
US20080238709A1 (en) * 2007-03-28 2008-10-02 Faramarz Vaziri One-way communication apparatus with dynamic key generation
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP1983002A3 (de) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosinphosphorylations-Stellen und spezifische Antikörper
EP1983003A3 (de) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosinphosphorylationsstellen und spezifische Antikörper
US20090053831A1 (en) 2007-05-01 2009-02-26 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
WO2009012175A1 (en) 2007-07-13 2009-01-22 Ventana Medical Systems, Inc. Antibodies specific for the c-terminal regulatory domain of egfr and their use
EP2203558B1 (de) 2007-10-18 2016-05-04 Cell Signaling Technology, Inc. Translokation und mutations-ros-kinase bei menschlichem nicht-kleinzelligem bronchialkarzinom
JP2011514881A (ja) 2007-11-09 2011-05-12 ザ ソルク インスティテュート フォー バイオロジカル スタディーズ 免疫増強剤としてのｔａｍ受容体阻害剤の使用および免疫抑制剤としてのｔａｍ活性化剤の使用
CA2705923A1 (en) 2007-11-16 2009-05-22 Nuvelo, Inc. Antibodies to lrp6
EP2062920A3 (de) 2007-11-21 2009-06-17 Peter Hornbeck Proteinphosphorylation durch basophilische Serin-/Threonin-Kinasen in Insulinsignalisierungspfaden
WO2015164330A1 (en) 2014-04-21 2015-10-29 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
EP3023502A1 (de) 2008-04-10 2016-05-25 Cell Signaling Technology, Inc. Zusammensetzungen und verfahren zur erkennung von egfr-mutationen bei krebs
WO2009151505A1 (en) * 2008-04-11 2009-12-17 China Molecular, Ltd. Devices and methods for immunoglobulin production
EP2279203B1 (de) 2008-04-25 2016-06-15 University Of Saskatchewan Prionenepitope und verwendungsverfahren dafür
WO2009158040A2 (en) * 2008-06-26 2009-12-30 University Of South Florida Cancer platinum resistance detection and sensitization method
PL2881402T3 (pl) 2009-02-12 2017-10-31 Cell Signaling Technology Inc Ekspresja zmutowanej ROS w ludzkim raku wątroby
JP5764071B2 (ja) 2009-02-24 2015-08-12 エスバテック − ア ノバルティスカンパニー エルエルシー 細胞表面抗原のイムノバインダーを同定するための方法
US20120101108A1 (en) 2010-08-06 2012-04-26 Cell Signaling Technology, Inc. Anaplastic Lymphoma Kinase In Kidney Cancer
EP2614085B1 (de) 2010-09-10 2016-04-20 Apexigen, Inc. Anti-il-1-antikörper und verfahren zu ihrer verwendung
KR20140043724A (ko) 2011-03-03 2014-04-10 아펙시젠, 인코포레이티드 항-il-6 수용체 항체 및 사용 방법
EP2702078B1 (de) 2011-04-29 2018-11-07 Apexigen, Inc. Anti-cd40-antikörper und verfahren zu ihrer verwendung
EP2785742B1 (de) 2011-11-02 2020-01-08 Apexigen, Inc. Anti-kdr-antikörper und verwendungsverfahren dafür
SI2838998T1 (en) 2012-04-18 2018-04-30 Cell Signaling Technology, Inc. EGFR AND ROS1 PRI CRAK
US10155987B2 (en) 2012-06-12 2018-12-18 Dana-Farber Cancer Institute, Inc. Methods of predicting resistance to JAK inhibitor therapy
JP6693745B2 (ja) 2012-10-30 2020-05-13 アペクシジェン， インコーポレイテッド 抗ｃｄ４０抗体および使用方法
EP2778176A1 (de) 2013-03-12 2014-09-17 Sanofi Zusammensetzungen und Verfahren zur Analyse der Histidinphosphorylierung
EP2970462A4 (de) 2013-03-14 2017-02-22 Apexigen, Inc. Anti-rankl-antikörper und verfahren zur verwendung
WO2014186878A1 (en) 2013-05-24 2014-11-27 Cashman Neil R Cell senescence markers as diagnostic and therapeutic targets
EP3077815B1 (de) 2013-12-03 2019-07-17 President and Fellows of Harvard College Verfahren und reagenzien zur beurteilung von schwangerschaftsdiabetes
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IL257565B1 (en) 2015-09-23 2024-04-01 Genentech Inc Improved variants of anti-VEGF antibodies
JP2019501864A (ja) 2015-10-07 2019-01-24 ジェネンテック， インコーポレイテッド 治療剤−ポリマーコンジュゲートの硝子体内半減期を予測するシステム及び方法
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EP3656794A1 (de) 2018-11-23 2020-05-27 Centre National De La Recherche Scientifique Zusammensetzungen und verfahren zur detektion von krebs
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4736866A (en) * 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
US4859595A (en) * 1985-05-03 1989-08-22 Strosberg Arthur D Method for preparing rabbit monoclonal antibodies, the cell lines used therein and the antibodies produced thereby
FR2596414B1 (fr) * 1986-03-28 1989-10-06 Pasteur Institut Hybridomes obtenus a partir de lymphocytes d'animaux transgeniques portant un gene exprimant une proteine donnee et procede de preparation d'une telle proteine a partir de tels hybridomes

Also Published As

Publication number Publication date
ATE297982T1 (de) 2005-07-15
EP0815213B1 (de) 2005-06-15
AU4989296A (en) 1996-09-18
WO1996027004A1 (en) 1996-09-06
DE69634851T2 (de) 2006-05-04
US5675063A (en) 1997-10-07
CA2214018C (en) 2007-09-25
CA2214018A1 (en) 1996-09-06
EP0815213A1 (de) 1998-01-07
EP0815213A4 (de) 2001-09-05

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Legal Events

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8364 No opposition during term of opposition