DE69634127D1 - Zellfreie synthese von polyketiden - Google Patents

Zellfreie synthese von polyketiden

Info

Publication number
DE69634127D1
DE69634127D1 DE69634127T DE69634127T DE69634127D1 DE 69634127 D1 DE69634127 D1 DE 69634127D1 DE 69634127 T DE69634127 T DE 69634127T DE 69634127 T DE69634127 T DE 69634127T DE 69634127 D1 DE69634127 D1 DE 69634127D1
Authority
DE
Germany
Prior art keywords
cell
polycetides
free synthesis
polyketides
modular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634127T
Other languages
English (en)
Inventor
Chaitan Khosla
Rembert Pieper
Guanglin Luo
E Cane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brown University Research Foundation Inc
Leland Stanford Junior University
Original Assignee
Brown University Research Foundation Inc
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brown University Research Foundation Inc, Leland Stanford Junior University filed Critical Brown University Research Foundation Inc
Application granted granted Critical
Publication of DE69634127D1 publication Critical patent/DE69634127D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69634127T 1995-07-06 1996-07-05 Zellfreie synthese von polyketiden Expired - Lifetime DE69634127D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US333895P 1995-07-06 1995-07-06
PCT/US1996/011317 WO1997002358A1 (en) 1995-07-06 1996-07-05 Cell-free synthesis of polyketides

Publications (1)

Publication Number Publication Date
DE69634127D1 true DE69634127D1 (de) 2005-02-03

Family

ID=21705358

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634127T Expired - Lifetime DE69634127D1 (de) 1995-07-06 1996-07-05 Zellfreie synthese von polyketiden

Country Status (10)

Country Link
US (5) US6080555A (de)
EP (2) EP1493814A1 (de)
JP (1) JP3633629B2 (de)
AT (1) ATE286133T1 (de)
AU (1) AU706445B2 (de)
CA (1) CA2226221C (de)
DE (1) DE69634127D1 (de)
IL (2) IL122859A0 (de)
NZ (1) NZ313383A (de)
WO (1) WO1997002358A1 (de)

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US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US20080003648A1 (en) * 1997-04-30 2008-01-03 Chaitan Khosla Method to prepare macrolide analogs
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US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
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WO2000063361A2 (en) * 1999-04-16 2000-10-26 Kosan Biosciences, Inc. A multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
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US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
US7033818B2 (en) * 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
DE60043509D1 (de) 1999-10-13 2010-01-21 Nior University Biosynthese von Polyketidsynthase-Substrate
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US6929935B2 (en) 2001-12-19 2005-08-16 Bristol-Myers Squibb Company Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof
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WO2004053065A2 (en) 2002-12-06 2004-06-24 Kosan Biosciences, Inc. Disorazole polyketide synthase encoding polynucleotides
US7459294B2 (en) * 2003-08-08 2008-12-02 Kosan Biosciences Incorporated Method of producing a compound by fermentation
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US7348436B2 (en) * 2004-03-02 2008-03-25 Kosan Biosciences Incorporated Compounds useful for the synthesis of (+)-discodermolide and methods thereof
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US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US8759031B2 (en) 2007-04-12 2014-06-24 Wisconsin Alumni Research Foundation Type I polyketide synthase extender units
BRPI0909839A2 (pt) 2008-03-28 2017-06-13 Univ California produção de ácidos dicarboxílicos usando policetídeo sintases
US8420833B2 (en) 2008-04-29 2013-04-16 The Regents Of The University Of California Producing biofuels using polyketide synthases
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ES2718844T3 (es) 2010-05-07 2019-07-04 Greenlight Biosciences Inc Métodos para controlar el flujo en rutas metabólicas mediante la reubicación de enzimas
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US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
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Also Published As

Publication number Publication date
EP0836649A1 (de) 1998-04-22
EP0836649B1 (de) 2004-12-29
US6080555A (en) 2000-06-27
CA2226221A1 (en) 1997-01-23
EP1493814A1 (de) 2005-01-05
US6750040B1 (en) 2004-06-15
US20040203119A1 (en) 2004-10-14
WO1997002358A1 (en) 1997-01-23
AU6542696A (en) 1997-02-05
EP0836649A4 (de) 2000-04-05
US6531299B1 (en) 2003-03-11
US7101684B2 (en) 2006-09-05
AU706445B2 (en) 1999-06-17
IL122859A (en) 2009-05-04
JPH10510167A (ja) 1998-10-06
NZ313383A (en) 1999-08-30
CA2226221C (en) 2001-05-08
JP3633629B2 (ja) 2005-03-30
ATE286133T1 (de) 2005-01-15
IL122859A0 (en) 1998-08-16
US6274560B1 (en) 2001-08-14

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