DE69631229T2 - Herstellung von virusinaktivierten intravenös injektierbaren Globulin aus Immunserum - Google Patents

Herstellung von virusinaktivierten intravenös injektierbaren Globulin aus Immunserum Download PDF

Info

Publication number
DE69631229T2
DE69631229T2 DE69631229T DE69631229T DE69631229T2 DE 69631229 T2 DE69631229 T2 DE 69631229T2 DE 69631229 T DE69631229 T DE 69631229T DE 69631229 T DE69631229 T DE 69631229T DE 69631229 T2 DE69631229 T2 DE 69631229T2
Authority
DE
Germany
Prior art keywords
antibody solution
antibody
solution
aca
detergent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69631229T
Other languages
German (de)
English (en)
Other versions
DE69631229D1 (de
Inventor
William R. Cary Alonso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24120836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69631229(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69631229D1 publication Critical patent/DE69631229D1/de
Publication of DE69631229T2 publication Critical patent/DE69631229T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A61L2103/05—

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DE69631229T 1995-09-22 1996-09-10 Herstellung von virusinaktivierten intravenös injektierbaren Globulin aus Immunserum Expired - Lifetime DE69631229T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/532,211 US6686191B1 (en) 1995-09-22 1995-09-22 Preparation of virally inactivated intravenously injectable immune serum globulin
US532211 1995-09-22

Publications (2)

Publication Number Publication Date
DE69631229D1 DE69631229D1 (de) 2004-02-05
DE69631229T2 true DE69631229T2 (de) 2004-12-02

Family

ID=24120836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631229T Expired - Lifetime DE69631229T2 (de) 1995-09-22 1996-09-10 Herstellung von virusinaktivierten intravenös injektierbaren Globulin aus Immunserum

Country Status (10)

Country Link
US (1) US6686191B1 (enExample)
EP (2) EP0764447B1 (enExample)
JP (1) JP4036494B2 (enExample)
AT (1) ATE257016T1 (enExample)
AU (1) AU709608B2 (enExample)
CA (1) CA2185859C (enExample)
DE (1) DE69631229T2 (enExample)
DK (1) DK0764447T3 (enExample)
ES (1) ES2213760T3 (enExample)
PT (1) PT764447E (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6914998A (en) * 1997-04-07 1998-10-30 Cangene Corporation Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties
EP0973544B1 (de) 1997-04-08 2001-06-27 Baxter Aktiengesellschaft Immuntolerante prothrombinkomplex-präparation
AT405608B (de) * 1997-04-08 1999-10-25 Immuno Ag Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
WO2001013423A1 (en) * 1999-08-10 2001-02-22 Ibiden Co., Ltd. Semiconductor production device ceramic plate
ATE442862T2 (de) 2000-10-12 2009-10-15 Genentech Inc Niederviskose konzentrierte proteinformulierungen
US8703126B2 (en) 2000-10-12 2014-04-22 Genentech, Inc. Reduced-viscosity concentrated protein formulations
KR100791502B1 (ko) * 2006-09-29 2008-01-03 한스바이오메드 주식회사 바이러스 불활화된 무세포 인체 이식재 생산방법
EP2077118A1 (en) * 2008-01-07 2009-07-08 Gwo Rei Biomedical Technology Corp. Clottable concentrate of platelet growth factors and preparation method thereof
AR076640A1 (es) 2009-03-06 2011-06-29 Genentech Inc Formulacion con anticuerpo. metodo para estabilizar anticuerpo. articulo de manufactura
CA2976671C (en) 2010-03-01 2021-01-12 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
CN102357259A (zh) * 2011-07-28 2012-02-22 王珊珊 一种生物蛋白海绵及其制备方法
CN104411820B (zh) 2012-06-29 2017-05-03 Emd密理博公司 在蛋白纯化过程中灭活病毒的方法
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396608A (en) * 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4762714A (en) * 1986-04-08 1988-08-09 Miles Laboratories, Inc. Preparation of retrovirus-free immunoglobulins
GB8628104D0 (en) * 1986-11-25 1986-12-31 Connaught Lab Pasteurization of immunoglobin solutions
ATE174383T1 (de) * 1991-07-05 1998-12-15 Bayer Ag Verwendung von tri-n-butylphosphat bei niedrigem ph in lösungen von biologisch aktiven proteinen für eine verbesserte viruzide wirkung

Also Published As

Publication number Publication date
JP4036494B2 (ja) 2008-01-23
EP0764447B1 (en) 2004-01-02
EP1356829A2 (en) 2003-10-29
DK0764447T3 (da) 2004-05-03
CA2185859A1 (en) 1997-03-23
ATE257016T1 (de) 2004-01-15
CA2185859C (en) 2011-04-19
EP0764447A3 (en) 1997-07-30
EP0764447A2 (en) 1997-03-26
EP1356829A3 (en) 2003-12-17
PT764447E (pt) 2004-04-30
AU709608B2 (en) 1999-09-02
AU6569096A (en) 1997-03-27
DE69631229D1 (de) 2004-02-05
US6686191B1 (en) 2004-02-03
JPH09124507A (ja) 1997-05-13
ES2213760T3 (es) 2004-09-01

Similar Documents

Publication Publication Date Title
DE69920693T2 (de) Verfahren zur herstellung von immunoglobulinen zur intravenösen verabreichung und anderen immunoglobulin-produkten
DE69225757T2 (de) Lyophilische monoklonale antikörperpräparationen
DE69631229T2 (de) Herstellung von virusinaktivierten intravenös injektierbaren Globulin aus Immunserum
DE69821741T2 (de) Immunoglobulin enthaltende zusammensetzung
DE2801123C2 (de) Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates
DE3927111C3 (de) Verfahren zur Herstellung nicht modifizierter intravenös verabreichbarer IgM- und/oderIgA-haltiger Immunglobulinpräparate
DE69808620T2 (de) Universell verwendbares bluttplasma
EP0122909B1 (de) Immunglobulin-G-hältige Fraktion
DE69120192T2 (de) Verfahren zur Herstellung von sekretorischen Immunoglobulin-A-Präparaten
DE3889938T2 (de) Injizierbare Lösungen von Gamma-Globulin.
CH640140A5 (de) Verfahren zur herstellung von intravenoes injizierbarem gamma-globulin.
DE3927112C1 (enExample)
DE2827027B2 (de) Gefriergetrocknetes natives T -globulin-Präparat zur intravenösen Verabreichung
EP0525502B1 (de) Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
EP0085747B2 (de) Intravenös verabreichbares humanes Immunglobulin und Verfahren zu dessen Herstellung
EP0247998B1 (de) Verfahren zur Inaktivierung von vermehrungsfähigen filtrierbaren Krankheitserregern
EP0139975A1 (de) Verfahren zur Pasteurisierung von Humanplasma
DE3604947C2 (enExample)
DE60226327T2 (de) Reinigungsverfahren zur grossmassstabigen produktion von gc-globulin, damit erhaltenes produkt und dessen verwendung in medizin
EP0249167B1 (de) Verfahren zur Herstellung einer pasteurisierten Immunglobulinpraeparation
DE1148037B (de) Verfahren zur Herstellung eines desaggregierten, das Komplementsystem nicht beeinflussenden Gammaglobulins
DE19611235C1 (de) Mittel zur Steigerung der Ausbeute von Antikörpern in der Immunologie 2
AT367297B (de) Verfahren zur herstellung eines serumeiweiss-pr[parates
DE2532276C3 (de) Verfahren zur Reinigung von Human-Antilymphozytenserum
DE2856939A1 (de) Verfahren zur gewinnung von intravenoes-vertraeglichen gammaglobulinen

Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings