DE69630524D1 - Methoden zur aufreinigung von authentischem igf aus hefewirtszellen - Google Patents

Methoden zur aufreinigung von authentischem igf aus hefewirtszellen

Info

Publication number
DE69630524D1
DE69630524D1 DE69630524T DE69630524T DE69630524D1 DE 69630524 D1 DE69630524 D1 DE 69630524D1 DE 69630524 T DE69630524 T DE 69630524T DE 69630524 T DE69630524 T DE 69630524T DE 69630524 D1 DE69630524 D1 DE 69630524D1
Authority
DE
Germany
Prior art keywords
methods
farms
year
purifying
authentic igf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69630524T
Other languages
English (en)
Other versions
DE69630524T2 (de
Inventor
Cynthia Cowgill
Luis Juarbe
Patricio Riquelme
Glenn Dorin
M Bussineau
D Kudrna
G Otzurk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Cephalon LLC
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/477,984 external-priority patent/US7193042B1/en
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DE69630524D1 publication Critical patent/DE69630524D1/de
Publication of DE69630524T2 publication Critical patent/DE69630524T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69630524T 1995-06-07 1996-06-07 Methoden zur aufreinigung von authentischem igf aus hefewirtszellen Expired - Fee Related DE69630524T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/477,984 US7193042B1 (en) 1995-06-07 1995-06-07 Methods for purifying authentic IGF from yeast hosts
US477984 1995-06-07
US66348196A 1996-06-06 1996-06-06
US663481 1996-06-06
PCT/US1996/009828 WO1996040776A1 (en) 1995-06-07 1996-06-07 Methods for purifying authentic igf from yeast hosts

Publications (2)

Publication Number Publication Date
DE69630524D1 true DE69630524D1 (de) 2003-12-11
DE69630524T2 DE69630524T2 (de) 2004-08-05

Family

ID=27045743

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69630524T Expired - Fee Related DE69630524T2 (de) 1995-06-07 1996-06-07 Methoden zur aufreinigung von authentischem igf aus hefewirtszellen

Country Status (7)

Country Link
US (1) US6117983A (de)
EP (1) EP0832121B1 (de)
JP (3) JP2002514890A (de)
AT (1) ATE253079T1 (de)
AU (1) AU6167596A (de)
DE (1) DE69630524T2 (de)
WO (1) WO1996040776A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7193042B1 (en) * 1995-06-07 2007-03-20 Chiron Corporation Methods for purifying authentic IGF from yeast hosts
US7071313B1 (en) * 1995-06-07 2006-07-04 Cephalon, Inc. Methods of purifying authentic IGF from yeast hosts
EP1003889A1 (de) 1997-08-05 2000-05-31 Chiron Corporation Gensequenzen aus pichia pastoris und deren verwendung
US7067485B2 (en) 1997-11-07 2006-06-27 Chiron Corporation IGF-I composition and its use
ES2228052T3 (es) 1998-06-01 2005-04-01 Genentech, Inc. Separacion demonomeros de anticuerpos de sus multimeros utilizando cromatografia de intercambio de iones.
US6605450B1 (en) 2000-05-25 2003-08-12 Chiron Corporation Iron regulation of the PpSEC10 transcriptional regulatory region of Pichia pastoris and methods of use
WO2002004481A2 (en) * 2000-07-12 2002-01-17 Eli Lilly And Company Process to increase protein stability
AU2003901507A0 (en) * 2003-03-28 2003-04-17 Norika Holdings Process for isolating a pharmaceutical product
EP1988154B1 (de) * 2007-04-30 2013-08-21 Ajinomoto Co., Inc. Verfahren zur Herstellung des humanen insulinähnlichen Wachstumsfaktors I
WO2012104339A1 (en) * 2011-02-01 2012-08-09 Novo Nordisk A/S Purification of insulin
BR112021012742A2 (pt) 2018-12-31 2021-09-08 OmniGen Research, L.L.C. Suplementos alimentares
MX2022015448A (es) 2020-06-12 2023-01-16 Phibro Animal Health Corporation Composicion o combinacion que comprende suplemento dietetico anionico y 25-hidroxi vitamina d.
WO2023192262A1 (en) 2022-04-01 2023-10-05 Phibro Animal Health Corporation A combination comprising bacillus and an essential oil and methods for making and using

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06500470A (ja) * 1990-09-04 1994-01-20 メルク　エンド　カンパニー　インコーポレーテッド メチロトローフ酵母細胞におけるインスリン様成長因子の産生
US5231178A (en) * 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
WO1993019084A1 (en) * 1992-03-24 1993-09-30 Synergen, Inc. Refolding and purification of insulin-like growth factor i
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
US5407810A (en) * 1993-08-20 1995-04-18 Genentech, Inc. Aqueous multiple-phase isolation of polypeptide
US5451660A (en) * 1993-12-13 1995-09-19 Genentech, Inc. Method for purifying polypeptides
US5446024A (en) * 1993-12-17 1995-08-29 Genentech, Inc. Purification of insulin-like growth factor
JPH10504971A (ja) * 1994-09-08 1998-05-19 カイロン コーポレイション インスリン様増殖因子の改善された生産方法
US5650496A (en) * 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process

Also Published As

Publication number Publication date
AU6167596A (en) 1996-12-30
JP2002514890A (ja) 2002-05-21
WO1996040776A1 (en) 1996-12-19
US6117983A (en) 2000-09-12
EP0832121B1 (de) 2003-10-29
DE69630524T2 (de) 2004-08-05
JP2005253475A (ja) 2005-09-22
ATE253079T1 (de) 2003-11-15
JP2008054693A (ja) 2008-03-13
EP0832121A1 (de) 1998-04-01

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CHIRON CORP., EMERYVILLE, CALIF., US

Owner name: CEPHALON, INC., WEST CHESTER, PA., US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CEPHALON, INC., WEST CHESTER, PA., US

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US

8339 Ceased/non-payment of the annual fee